US4111968A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Process
Assignee: Pharmacia and Upjohn Co
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Filing: 1977-07-29
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Granted: 1978-09-05
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Expires: 1997-07-29
Abstract
Abstract A new method for preparing cytosine arabinoside involving the cyanovinylation of the aminooxazoline of D-arabinose by cis-β-[trimethylammonium]-acrylonitrile tosylate. Also included are new preparations of the aminooxazoline of D-arabinose and the anion of cis-1-cyano-2-hydroxyethylene.
Inventors
- 👤 Edward J. Hessler
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-30 14:01
CPC Classifications
C; C07; C07H; C07H19/00; C07H19/02; C07H19/04; C07H19/06
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
63 words
A process for selectively preparing a salt which comprises contacting isoxazole with a base of a strength equal to or greater than sodium methoxide in an inert organic solvent at a temperature less than or equal to about -40° C., the anion of said salt being the anion of cis-1-cyano-2-hydroxyethylene and the cation of said salt being the positive portion of said base.
Claim 2
Dependent Claim
63 words
A process for selectively preparing a salt which comprises contacting isoxazole with a base of a strength equal to or greater than sodium methoxide in an inert organic solvent at a temperature less than or equal to about -40° C., the anion of said salt being the anion of cis-1-cyano-2-hydroxyethylene and the cation of said salt being the positive portion of said base.
Claim 3
Dependent Claim
18 words
A process in accordance with claim 1 wherein the base is potassium tert-butoxide and the solvent is tetrahydrofuran.
Claim 4
Dependent Claim
79 words
A process for selectively preparing a salt which comprises contacting isotazole with a base of a strength equal to or greater than sodium methoxide in an inert organic solvent at a temperature less than or equal to about -20° C. and the isoxazole is precooled to a temperature less than or equal to about -20° C., the anion of said salt being the anion of cis-1-cyano-2-hydroxyethylene and the cation of said salt being the positive portion of the base.
Claim 5
Dependent Claim
79 words
A process for selectively preparing a salt which comprises contacting isotazole with a base of a strength equal to or greater than sodium methoxide in an inert organic solvent at a temperature less than or equal to about -20° C. and the isoxazole is precooled to a temperature less than or equal to about -20° C., the anion of said salt being the anion of cis-1-cyano-2-hydroxyethylene and the cation of said salt being the positive portion of the base.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-09-04 | 1982-03-06 | 1982-09-05 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-09-04 | 1986-03-06 | 1986-09-05 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-09-04 | 1990-03-06 | 1990-09-05 | $7700.00 | Window Closed / Lapsed |