US4110451A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Antiinflammatory imidazothiazoles and thiazolopyrimidines
Assignee: RICERCA Inc A CORP OF DE
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Filing: 1976-12-29
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Granted: 1978-08-29
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Expires: 1996-12-29
Abstract
Abstract Certain imidazothiazoles and thiazolopyrimidines have been found to prevent and inhibit the formation of granuloma tissue in animals. This result is accomplished by administering to the animal subject a therapeutically effective amount of a compound having the formula: ##STR1## wherein R is hydrogen or methyl, R' is hydrogen, lower alkyl or thioalkyl, carboxy methyl, or phenyl; R" is lower alkyl, 2-benzofuranyl, naphthyl, phenyl, or mono- or disubstituted phenyl. The hydrated precursors of certain of these compounds as well as the acid addition and quaternary salts of both the compounds and their hydrated precursors may be employed.
Inventors
- 👤 Robert E. Moser
- 👤 Larry J. Powers
- 👤 Zaven S. Ariyan
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 22:12
CPC Classifications
C; C07; C07D; C07D513/00; C07D513/02; C07D513/04; C07D235/00; C07D235/02; C07D235/04; C07D235/24; C07D235/28
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
72 words
A method of treating inflammation in an animal subject comprising administering to said subject a nontoxic antiinflammatory amount of a compound of the formula: ##STR10## wherein n is 3; R is hydrogen or methyl; R' is hydrogen, C 1 -C 3 alkyl or thioalkyl, phenyl, or carboxy methyl; and R" is C 1 -C 4 alkyl, 2-benzofuranyl, naphthyl, phenyl, or mono- or disubstituted phenyl, or an acid addition or quaternary salt thereof.
Claim 2
Independent Claim
72 words
A method of treating inflammation in an animal subject comprising administering to said subject a nontoxic antiinflammatory amount of a compound of the formula: ##STR10## wherein n is 3; R is hydrogen or methyl; R' is hydrogen, C 1 -C 3 alkyl or thioalkyl, phenyl, or carboxy methyl; and R" is C 1 -C 4 alkyl, 2-benzofuranyl, naphthyl, phenyl, or mono- or disubstituted phenyl, or an acid addition or quaternary salt thereof.
Claim 3
Dependent Claim
20 words
The method as defined in claim 1 wherein said nontoxic antiinflammatory amount ranges between about 10 to about 500 mg/kg/day.
Claim 4
Dependent Claim
13 words
The method as defined in claim 1 wherein said compound is 2-methyl-3-phenyl-4,5,6,7-tetrahydrothiazolo [3,2-a]-pyrimidine.
Claim 5
Dependent Claim
13 words
The method as defined in claim 1 wherein said compound is 3-phenyl-4,5,6,7-tetrahydrothiazo[3,2-a] pyrimidine.
Claim 6
Independent Claim
50 words
A method of treating inflammation in an animal subject comprising administering to said subject a nontoxic antiinflammatory amount of a compound of the formula: ##STR11## wherein n is 3; R is hydrogen or methyl; and Y is phenyl or p-chloro- or p-methoxyphenyl, or an acid addition or quaternary salt thereof.
Claim 7
Independent Claim
50 words
A method of treating inflammation in an animal subject comprising administering to said subject a nontoxic antiinflammatory amount of a compound of the formula: ##STR11## wherein n is 3; R is hydrogen or methyl; and Y is phenyl or p-chloro- or p-methoxyphenyl, or an acid addition or quaternary salt thereof.
Claim 8
Dependent Claim
20 words
The method as defined in claim 5, wherein said nontoxic antiinflammatory amount ranges between about 10 to about 500 mg/kg/day.
Claim 9
Dependent Claim
12 words
The method as defined in claim 5 wherein said compound is 3-phenyl-3-hydroxy-2,3,6,7-tetrahydrothiazolo[3,2-a]-pyrimidine.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-08-28 | 1982-02-27 | 1982-08-29 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-08-28 | 1986-02-27 | 1986-08-29 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-08-28 | 1990-02-27 | 1990-08-29 | $7700.00 | Window Closed / Lapsed |