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US4110161A Expired / Lapsed US ⏱️ 0.0 years remaining

Process for inhibiting platelet aggregation

Assignee: Pharmacia and Upjohn Co
•
Filing: 1977-03-07
•
Granted: 1978-08-29
•
Expires: 1997-03-07
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Abstract

Abstract A process for inhibiting platelet aggregation by the addition of a member selected from the group consisting of a compound of the formula: <IMAGE> Formula I wherein Y is lower alkyl of 1 to 8 carbon atoms, cyclopropyl, ethinyl, -CF3, -F, -Cl, -OCH3, -OCHF3, -OCH2OCH3, -SCH3, -SCHF2, -SCH2OCH3, acetyl; R1 and R2 are H, CH3, CHF2, or taken together are =CH2 or =CF2; and X is hydrogen, lower alkyl of 1 to 8 carbon atoms or a pharmacologically acceptable cation, to in vivo and in vitro platelet systems. In vitro systems include whole blood as kept in blood banks, whole blood as used in heart-lung machines, and platelet rich concentrates. In vivo systems include human or animal bodies. The process provides a means for treating hemorrhage due to thrombocytopenia which in turn is caused by irradiation, cancer chemotherapy, or immunosuppressants as well as hemophilia due to congenital defects.

Inventors

  • 👤 Neel C. Sekhar

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-11-04 23:04
CPC Classifications
A; A01; A01N; A01N1/00; A01N1/10; A01N1/12; A01N1/122; A01N1/126; A61; A61K; A61K31/00; A61K31/185; A61K31/19; A61K31/21; A61K31/215; A61K31/22; A61K35/00; A61K35/12; A61K35/14; A61K35/19

Claims Analysis

Total Claims: 3
Claim 1
Independent Claim 104 words
A process for inhibiting platelet aggregation in vitro comprising the addition of an effective amount for inhibiting platelet aggregation of a compound of the formula: ##STR2## wherein Y is lower alkyl of 1 to 8 carbon atoms, cyclopropyl, ethinyl, --CF 3 , --F, --Cl, --OCH 3 , --OCH 2 OCH 3 , --SCH 3 , --SCHF 2 , --SCH 2 OCH 3 , acetyl; R 1 and R 2 are H, CH 3 , CHF 2 , or taken together are ═CH 2 or ═CF 2 ; and X is lower alkyl of 1 to 8 carbon atoms, to whole blood or platelet-rich concentrates.
Claim 2
Dependent Claim 104 words
A process for inhibiting platelet aggregation in vitro comprising the addition of an effective amount for inhibiting platelet aggregation of a compound of the formula: ##STR2## wherein Y is lower alkyl of 1 to 8 carbon atoms, cyclopropyl, ethinyl, --CF 3 , --F, --Cl, --OCH 3 , --OCH 2 OCH 3 , --SCH 3 , --SCHF 2 , --SCH 2 OCH 3 , acetyl; R 1 and R 2 are H, CH 3 , CHF 2 , or taken together are ═CH 2 or ═CF 2 ; and X is lower alkyl of 1 to 8 carbon atoms, to whole blood or platelet-rich concentrates.
Claim 3
Dependent Claim 24 words
The process of claim 1 wherein the amount of the compound added is from about 0.01 to 50 micrograms per ml. of whole blood.

References Cited (Backward Citations)

No citation records indexed.

USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 1981-08-28 1982-02-27 1982-08-29 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 1985-08-28 1986-02-27 1986-08-29 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 1989-08-28 1990-02-27 1990-08-29 $7700.00 Window Closed / Lapsed

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