US4109014A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Pharmaceutical, compositions containing substituted 4'-hydroxyphenyl guanidines and methods of using same
Assignee: Armour Pharmaceutical Co
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Filing: 1977-01-25
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Granted: 1978-08-22
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Expires: 1997-01-25
Abstract
Abstract Novel aromatic guanidine compounds having the formula: ##STR1## wherein: R 1 is hydroxyl, methyl or hydroxymethyl and R 2 is hydrogen or methyl, are found to have biological activity. The guanidine compounds and their salts are shown to be active as vasoconstrictor agents and create useful pharmaceutical preparations when deployed with a pharmaceutically acceptable carrier for administration to a host, e.g., man, requiring vasoconstrictive therapy.
Inventors
- 👤 Robert Chung-Huan Liu
- 👤 John Lawrence Hughes
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 13:52
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/13; A61K31/155
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
47 words
A pharmaceutical composition consisting of a pharmaceutical grade carrier and a therapeutically effective vasoconstrictive amount of a guanidine compound of a non-toxic acid addition salt thereof, said compound having the formula: ##STR3## wherein: R 1 is hydroxyl, methyl or hydroxymethyl; and R 2 is hydrogen or methyl.
Claim 2
Dependent Claim
47 words
A pharmaceutical composition consisting of a pharmaceutical grade carrier and a therapeutically effective vasoconstrictive amount of a guanidine compound of a non-toxic acid addition salt thereof, said compound having the formula: ##STR3## wherein: R 1 is hydroxyl, methyl or hydroxymethyl; and R 2 is hydrogen or methyl.
Claim 3
Dependent Claim
13 words
A composition according to claim 1 wherein said addition salt is 3',4'-dihydroxyphenylguanidine hydrochloride.
Claim 4
Dependent Claim
13 words
A composition according to claim 1 wherein said addition salt is 4'-hydroxy-m-tolylguanidine sulfate.
Claim 5
Dependent Claim
13 words
A composition according to claim 1 wherein said addition salt is 4'-hydroxy-3'-hydroxymethylphenylguanidine hydrochloride.
Claim 6
Dependent Claim
34 words
A pharmaceutical composition according to claim 1 in a dosage unit form selected from the group consisting of tablets, filled capsules, packets, lozenges, glossets, sterile solutions, suspensions, emulsions, ointments, suppositories and soft gelatin capsules.
Claim 7
Dependent Claim
47 words
The method of treating a host requiring vasoconstriction comprising administering to said host from about 1 mg to about 5 mg per kilogram of host body weight of a compound according to claim 1 or a non-toxic acid addition salt thereof to provide vasoconstriction in said host.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-08-21 | 1982-02-20 | 1982-08-22 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-08-21 | 1986-02-20 | 1986-08-22 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-08-21 | 1990-02-20 | 1990-08-22 | $7700.00 | Window Closed / Lapsed |