US4104469A
Expired / Lapsed
US
⏱️ 0.0 years remaining
7-(Syn-α-alkoxy-iminofuryl)acetamido-3-(2-methyl-2,3-dihydro-s-triazolo[4,3-b]pyridazin-3-on-6-ylthiomethyl)-3-cephem-4-carboxylic acids
Assignee: Bristol Myers Co
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Filing: 1977-04-15
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Granted: 1978-08-01
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Expires: 1997-04-15
Abstract
Abstract Cephalosporins in a series having the formula <IMAGE> +TR <IMAGE> wherein R1 is alkyl containing 1-4 carbon atoms or a nontoxic pharmaceutically acceptable salt thereof, were synthesized and found to be potent antibacterial agents especially when in the form of the syn isomers essentially free of the corresonding anti isomer.
Inventors
- 👤 Takayuki Naito
- 👤 Jun Okumura
- 👤 Seiji Iimura
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 20:16
CPC Classifications
C; C07; C07D; C07D487/00; C07D487/02; C07D487/04; C07D307/00; C07D307/02; C07D307/34; C07D307/56; C07D317/00; C07D317/08; C07D317/10; C07D317/32; C07D317/34
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
53 words
A compound having the formula ##STR31## wherein R 1 is alkyl of 1-4 carbon atoms and R 2 is hydrogen or pivaloyloxymethyl, acetoxymethyl, methoxymethyl, acetonyl, phenacyl, p-nitrobenzyl, β,β,β-trichloroethyl, 3-phthalidyl or 5-indanyl or a nontoxic, pharmaceutically acceptable salt thereof, said compound being at least 75% by weight in the form of its syn isomer.
Claim 2
Dependent Claim
53 words
A compound having the formula ##STR31## wherein R 1 is alkyl of 1-4 carbon atoms and R 2 is hydrogen or pivaloyloxymethyl, acetoxymethyl, methoxymethyl, acetonyl, phenacyl, p-nitrobenzyl, β,β,β-trichloroethyl, 3-phthalidyl or 5-indanyl or a nontoxic, pharmaceutically acceptable salt thereof, said compound being at least 75% by weight in the form of its syn isomer.
Claim 3
Dependent Claim
41 words
The syn isomer of a compound having the formula ##STR32## wherein R 1 is alkyl of 1-4 carbon atoms and R 2 is hydrogen, pivaloyloxymethyl, acetoxymethyl, methoxymethyl, acetonyl, phenacyl, p-nitrobenzyl, β,β,β-trichloroethyl, 3-phthalidyl or 5-indanyl or a nontoxic, pharmaceutically acceptable salt thereof.
Claim 4
Dependent Claim
41 words
The syn isomer of a compound having the formula ##STR32## wherein R 1 is alkyl of 1-4 carbon atoms and R 2 is hydrogen, pivaloyloxymethyl, acetoxymethyl, methoxymethyl, acetonyl, phenacyl, p-nitrobenzyl, β,β,β-trichloroethyl, 3-phthalidyl or 5-indanyl or a nontoxic, pharmaceutically acceptable salt thereof.
Claim 5
Dependent Claim
26 words
The syn isomer of a compound having the formula ##STR33## wherein R 1 is alkyl of 1-4 carbon atoms or a nontoxic, pharmaceutically acceptable salt thereof.
Claim 6
Dependent Claim
26 words
The syn isomer of a compound having the formula ##STR33## wherein R 1 is alkyl of 1-4 carbon atoms or a nontoxic, pharmaceutically acceptable salt thereof.
Claim 7
Dependent Claim
17 words
The syn isomer of a compound having the formula ##STR34## or a nontoxic, pharmaceutically acceptable salt thereof.
Claim 8
Dependent Claim
17 words
The syn isomer of a compound having the formula ##STR34## or a nontoxic, pharmaceutically acceptable salt thereof.
Claim 9
Dependent Claim
17 words
The syn isomer of a compound having the formula ##STR35## or a nontoxic, pharmaceutically acceptable salt thereof.
Claim 10
Dependent Claim
17 words
The syn isomer of a compound having the formula ##STR35## or a nontoxic, pharmaceutically acceptable salt thereof.
References Cited (Backward Citations)
US4024134A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-07-31 | 1982-01-30 | 1982-08-01 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-07-31 | 1986-01-30 | 1986-08-01 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-07-31 | 1990-01-30 | 1990-08-01 | $7700.00 | Window Closed / Lapsed |