US4101673A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Purification of nutritive oils
Assignee: Vitrum AB
•
Filing: 1976-12-13
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Granted: 1978-07-18
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Expires: 1996-12-13
Abstract
Abstract Parenterally administrable oil-in-water emulsions formed from nutritive oils, such as soybean and sunflower oils, are improved first by treating the nutritive oil with silicic acid to remove undesirable components such as peroxides, pigments, thermal and oxidative decomposition products, certain unsaponifiable matter such as sterols, and polymers. Purification is effected by treating the oil with silicic acid or silica gel either directly, or as a solution thereof in a suitable solvent, such as hexane. Autoxidation of the purified oil is prevented by adding to the purified oil a tocopherol antioxidant, γ-tocopherol being preferred. There is also added a metal scavenging agent such as ascorbyl palmitate.
Inventors
- 👤 Stephen S. Chang
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 21:25
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/21; A61K31/215; A61K31/22; A61K31/23; C; C11; C11B; C11B3/00; C11B3/10; C11B5/00; C11B5/0092
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
89 words
A nutritive oil-in-water emulsion suitable for parenteral administration, comprising an oil selected from the group consisting of soybean oil and sunflower oil, an emulsifier for said oil, and water wherein the improvement comprises: contacting said nutritive oil with an adsorbant selected from the group consisting of silicic acid and silica gel, to substantially remove non-urea-adduct forming esters and unsaponifiable matter from said nutritive oil, recovering said oil from the adsorbant, and subsequently combining the recovered nutritive oil with sterile water and an emulsifier to produce an improved oil-in-water emulsion.
Claim 2
Dependent Claim
89 words
A nutritive oil-in-water emulsion suitable for parenteral administration, comprising an oil selected from the group consisting of soybean oil and sunflower oil, an emulsifier for said oil, and water wherein the improvement comprises: contacting said nutritive oil with an adsorbant selected from the group consisting of silicic acid and silica gel, to substantially remove non-urea-adduct forming esters and unsaponifiable matter from said nutritive oil, recovering said oil from the adsorbant, and subsequently combining the recovered nutritive oil with sterile water and an emulsifier to produce an improved oil-in-water emulsion.
Claim 3
Dependent Claim
26 words
A nutritive oil-in-water emulsion as described in claim 1, wherein said oil is mixed with a solvent at the time it is contacted with said adsorbant.
Claim 4
Dependent Claim
27 words
A nutritive oil-in-water emulsion as described in claim 1, wherein said emulsion includes a tocopherol and a metal scavenger to inhibit the autoxidation of the emulsified oil.
Claim 5
Dependent Claim
38 words
A nutritive oil-in-water emulsion as described in claim 3, wherein said oil recovered from said adsorbant is sunflower oil and contains no more than about 0.29% of non-urea-adduct-forming esters, and contains no more than about 0.34% unsaponifiable matter.
Claim 6
Dependent Claim
38 words
A nutritive oil-in-water emulsion as described in claim 3, wherein said oil recovered from said adsorbant is soybean oil and contains no more than about 0.35% of non-urea-adduct-forming esters, and contains no more than about 0.15% unsaponifiable matter.
Claim 7
Independent Claim
73 words
A method of purifying a nutritive oil selected from the group consisting of soybean oil and sunflower oil to remove non-urea-adduct forming esters and unsaponifiable matter therefrom, said method comprising contacting said nutritive oil with an adsorbant selected from the group consisting of silicic acid and silica gel to substantially adsorb non-urea-adduct forming esters and unsaponifiable matter contained in said oil on the adsorbant and recovering the thusly purified oil from the adsorbant.
Claim 8
Independent Claim
73 words
A method of purifying a nutritive oil selected from the group consisting of soybean oil and sunflower oil to remove non-urea-adduct forming esters and unsaponifiable matter therefrom, said method comprising contacting said nutritive oil with an adsorbant selected from the group consisting of silicic acid and silica gel to substantially adsorb non-urea-adduct forming esters and unsaponifiable matter contained in said oil on the adsorbant and recovering the thusly purified oil from the adsorbant.
Claim 9
Dependent Claim
29 words
A method of purifying a nutritive oil as described in claim 6, wherein said oil is mixed with a solvent at the time it is contacted with said adsorbant.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-07-17 | 1982-01-16 | 1982-07-18 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-07-17 | 1986-01-16 | 1986-07-18 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-07-17 | 1990-01-16 | 1990-07-18 | $7700.00 | Window Closed / Lapsed |