US4101536A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Muramyldipeptide derivatives and process for the preparation thereof
Assignee: Daiichi Pharmaceutical Co Ltd
•
Filing: 1977-06-23
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Granted: 1978-07-18
•
Expires: 1997-06-23
Abstract
Abstract Muramyldipeptide derivatives of the formula: ##STR1## wherein Y represents a mycoloyl group or a synthetic higher acyl group having total carbon number of C30-C90 and having at least a branched chain of long alkyl group on the α-position thereof, Q represents an -L-alanyl-D-isoglutamine group, a -glycyl-D-isoglutamine group or an -L-seryl-D-isoglutamine group; Salts of such derivatives; the method of preparing such derivatives and their salts; the derivatives and their salts having potent immunoadjuvant activities and antitumor activity and being applicable as the agent for the immunotherapy of cancer for humans and animals.
Inventors
- 👤 Yuichi Yamamura
- 👤 Tetsuo Shiba
- 👤 Ichiro Azuma
- 👤 Shoichi Kusumoto
- 👤 Tadamasa Hirayama
- 👤 Tsuneo Kusama
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 00:38
CPC Classifications
C; C07; C07K; C07K9/00; C07K9/001; C07K9/005
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
57 words
Muramyldipeptide derivatives represented by the general formula ##STR5## wherein Y represents a mycoloyl group or a synthetic higher acyl group having a total carbon number of C 30 -C 90 and having at least a branched chain of long alkyl group on the α-position thereof; Q represents an -L-alanyl-D-isoglutamine group, a -glycyl-D-isoglutamine group, or an -L-seryl-D-isoglutamine group.
Claim 2
Dependent Claim
57 words
Muramyldipeptide derivatives represented by the general formula ##STR5## wherein Y represents a mycoloyl group or a synthetic higher acyl group having a total carbon number of C 30 -C 90 and having at least a branched chain of long alkyl group on the α-position thereof; Q represents an -L-alanyl-D-isoglutamine group, a -glycyl-D-isoglutamine group, or an -L-seryl-D-isoglutamine group.
Claim 3
Dependent Claim
1 words
6-O-mycomycoloyl-N-acetylmuramyl-L-alanyl-D-isoglutamine.
Claim 4
Dependent Claim
1 words
6-O-mycomycoloyl-N-acetylmuramyl-L-alanyl-D-isoglutamine.
Claim 5
Dependent Claim
1 words
6-O-corynomycoloyl-N-acetylmuramyl-L-alanyl-D-isoglutamine.
Claim 6
Dependent Claim
1 words
6-O-corynomycoloyl-N-acetylmuramyl-L-alanyl-D-isoglutamine.
Claim 7
Dependent Claim
1 words
6-O-nocardomycoloyl-N-acetylmuramyl-L-alanyl-D-isoglutamine.
Claim 8
Dependent Claim
1 words
6-O-nocardomycoloyl-N-acetylmuramyl-L-alanyl-D-isoglutamine.
Claim 9
Dependent Claim
1 words
6-O-mycomycoloyl-N-acetylmuramyl-L-seryl-D-isoglutamine.
Claim 10
Dependent Claim
1 words
6-O-mycomycoloyl-N-acetylmuramyl-L-seryl-D-isoglutamine.
Claim 11
Dependent Claim
1 words
6-O-nocardomycoloyl-N-acetylmuramyl-L-seryl-D-isoglutamine.
Claim 12
Dependent Claim
1 words
6-O-nocardomycoloyl-N-acetylmuramyl-L-seryl-D-isoglutamine.
Claim 13
Dependent Claim
1 words
6-O-(2-tetradecylhexadecanoyl)-N-acetylmuramyl-L-alanyl-D-isoglutamine.
Claim 14
Dependent Claim
1 words
6-O-(2-tetradecylhexadecanoyl)-N-acetylmuramyl-L-alanyl-D-isoglutamine.
Claim 15
Dependent Claim
21 words
The muramyldipeptide derivative of claim 1 wherein said long alkyl group at the α- position contains 8 to 25 carbon atoms.
Claim 16
Dependent Claim
65 words
The muramyldipeptide derivative of claim 1 wherein Y is a higher fatty acid having a total carbon number of about 70-90 with a long branch chain of an alkyl group of C 22 -C 24 on the α-position thereof or has a total carbon number of about 28-70 with a long branch chain alkyl group (C 8 -C 16 ) on the α- position thereof.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-07-17 | 1982-01-16 | 1982-07-18 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-07-17 | 1986-01-16 | 1986-07-18 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-07-17 | 1990-01-16 | 1990-07-18 | $7700.00 | Window Closed / Lapsed |