US4098889A
Expired / Lapsed
US
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Antithrombotic 2-(aminoalkylthio)-N,N'-p-phenylenebissulfonamides
Assignee: Dow Chemical Co
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Filing: 1977-09-01
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Granted: 1978-07-04
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Expires: 1997-09-01
Abstract
Abstract Novel antithrombotic 2-(aminoalkylthio)-N,N'-p-phenylenebissulfonamides, a method for inhibiting blood platelet aggregation, and pharmaceutical compositions.
Inventors
- 👤 Joseph E. Dunbar
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 06:15
CPC Classifications
C; C07; C07D; C07D295/00; C07D295/04; C07D295/08; C07D295/084; C07D295/088
Claims Analysis
Total Claims: 21
Claim 1
Independent Claim
85 words
A compound of the formula ##STR3## wherein n represents the integer 1, 2 or 3; R represents an alkyl having from 1 to about 3 carbon atoms or phenyl; and R' represents an alkyl having from 1 to about 4 carbon atoms or the two R' groups taken together with the adjacent nitrogen represented a 6-membered heterocyclic ring which may optionally contain an oxygen in the 4-position of the ring whereby a piperidinyl or morpholinyl residue is formed and further including the pharmaceutically-acceptable salts thereof.
Claim 2
Dependent Claim
85 words
A compound of the formula ##STR3## wherein n represents the integer 1, 2 or 3; R represents an alkyl having from 1 to about 3 carbon atoms or phenyl; and R' represents an alkyl having from 1 to about 4 carbon atoms or the two R' groups taken together with the adjacent nitrogen represented a 6-membered heterocyclic ring which may optionally contain an oxygen in the 4-position of the ring whereby a piperidinyl or morpholinyl residue is formed and further including the pharmaceutically-acceptable salts thereof.
Claim 3
Dependent Claim
13 words
The compound of claim 1 which is 2-(2-(diethylamino)ethylthio)-N,N'-p-phenylenebismethanesulfonamide and the pharmaceutically-acceptable salts thereof.
Claim 4
Dependent Claim
13 words
The compound of claim 1 which is 2-(2-(morpholinylamino)ethylthio)-N,N'-p-phenylenebismethanesulfonamide and the pharmaceutically-acceptable salts thereof.
Claim 5
Dependent Claim
13 words
The compound of claim 1 which is 2-(2-(isopropylamino)ethylthio)-N,N'-p-phenylenebismethanesulfonamide and the pharmaceutically-acceptable salts thereof.
Claim 6
Dependent Claim
13 words
The compound of claim 1 which is 2-(2-(diethylamino)ethylthio)-N,N'-p-phenylenebisbenzenesulfonamide and the pharmaceutically-acceptable salts thereof.
Claim 7
Dependent Claim
13 words
The compound of claim 1 which is 2-(2-(1-piperidino)ethylthio)-N,N'-p-phenylenebismethanesulfonamide and the pharmaceutically-acceptable salts thereof.
Claim 8
Independent Claim
112 words
A method of inhibiting the aggregation of blood platelets in a mammal which comprises administering internally to said mammal an effective blood platelet aggregation inhibiting amount of a compound of the formula ##STR4## wherein n represents the integer 1, 2 or 3; R represents an alkyl having from 1 to about 3 carbon atoms or phenyl; and R' represents an alkyl having from 1 to about 4 carbon atoms or the two R' groups taken together with the adjacent nitrogen represent a 6-membered heterocyclic ring which may optionally contain an oxygen in the 4-position of the ring whereby a piperidinyl or morpholinyl residue is formed and further including the pharmaceutically-acceptable salts thereof.
Claim 9
Independent Claim
112 words
A method of inhibiting the aggregation of blood platelets in a mammal which comprises administering internally to said mammal an effective blood platelet aggregation inhibiting amount of a compound of the formula ##STR4## wherein n represents the integer 1, 2 or 3; R represents an alkyl having from 1 to about 3 carbon atoms or phenyl; and R' represents an alkyl having from 1 to about 4 carbon atoms or the two R' groups taken together with the adjacent nitrogen represent a 6-membered heterocyclic ring which may optionally contain an oxygen in the 4-position of the ring whereby a piperidinyl or morpholinyl residue is formed and further including the pharmaceutically-acceptable salts thereof.
Claim 10
Dependent Claim
15 words
The method of claim 7 wherein the compound is 2-(2-(diethylamino)ethylthio)-N,N'-p-phenylenebismethanesulfonamide or a pharmaceutically-acceptable salt thereof.
Claim 11
Dependent Claim
15 words
The method of claim 7 wherein the compound is 2-(2-(morpholinyl)ethylthio)-N,N'-p-phenylenebismethanesulfonamide or a pharmaceutically-acceptable salt thereof.
Claim 12
Dependent Claim
15 words
The method of claim 7 wherein the compound is 2-(2-(isopropylamino)ethylthio)-N,N'-p-phenylenebismethanesulfonamide or a pharmaceutically-acceptable salt thereof.
Claim 13
Dependent Claim
15 words
The method of claim 7 wherein the compound is 2-(2-(diethylamino)ethylthio)-N,N'-p-phenylenebisbenzenesulfonamide or a pharmaceutically-acceptable salt thereof.
Claim 14
Dependent Claim
15 words
The method of claim 7 wherein the compound is 2-(2-(1-piperidino)ethylthio)-N,N'-p-phenylenebismethanesulfonamide or a pharmaceutically-acceptable salt thereof.
Claim 15
Dependent Claim
102 words
An antithrombotic composition which comprises a pharmaceutical carrier and an effective blood platelet aggregation inhibiting amount of a compound having the formula ##STR5## wherein n represents the integer 1, 2 or 3; R represents an alkyl having from 1 to about 3 carbon atoms or phenyl; and R' represent an alkyl having from 1 to about 4 carbon atoms or the two R' groups taken together with the adjacent nitrogen represent a 6-membered heterocyclic ring which may optionally contain an oxygen in the 4-position of the ring whereby a piperidinyl or morpholinyl residue is formed and further including the pharmaceutically-acceptable salts thereof.
Claim 16
Dependent Claim
102 words
An antithrombotic composition which comprises a pharmaceutical carrier and an effective blood platelet aggregation inhibiting amount of a compound having the formula ##STR5## wherein n represents the integer 1, 2 or 3; R represents an alkyl having from 1 to about 3 carbon atoms or phenyl; and R' represent an alkyl having from 1 to about 4 carbon atoms or the two R' groups taken together with the adjacent nitrogen represent a 6-membered heterocyclic ring which may optionally contain an oxygen in the 4-position of the ring whereby a piperidinyl or morpholinyl residue is formed and further including the pharmaceutically-acceptable salts thereof.
Claim 17
Dependent Claim
15 words
The composition of claim 13 wherein the compound is 2-(2-(diethylamino)ethylthio)-N,N'-p-phenylenebismethanesulfonamide or a pharmaceutically-acceptable salt thereof.
Claim 18
Dependent Claim
15 words
The composition of claim 13 wherein the compound is 2-(2-(morpholinyl)ethylthio)-N,N'-p-phenylenebismethanesulfonamide or a pharmaceutically-acceptable salt thereof.
Claim 19
Dependent Claim
15 words
The composition of claim 13 wherein the compound is 2-(2-(isopropylamino)ethylthio)-N,N'-p-phenylenebismethanesulfonamide or a pharmaceutically-acceptable salt thereof.
Claim 20
Dependent Claim
15 words
The composition of claim 13 wherein the compound is 2-(2-(diethylamino)ethylthio)-N,N'-p-phenylenebisbenzenesulfonamide or a pharmaceutically-acceptable salt thereof.
Claim 21
Dependent Claim
15 words
The composition of claim 13 wherein the conpound is 2-(2-(1-piperidinyl)ethylthio)-N,N'-p-phenylenebismethanesulfonamide or a pharmaceutically-acceptable salt thereof.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-07-03 | 1982-01-02 | 1982-07-04 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-07-03 | 1986-01-02 | 1986-07-04 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-07-03 | 1990-01-02 | 1990-07-04 | $7700.00 | Window Closed / Lapsed |