US4098879A
Expired / Lapsed
US
⏱️ 0.0 years remaining
N-alkyl-3-pyridinium-methanol fluorides and derivatives thereof
Assignee: Pierre Fabre SA
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Filing: 1977-01-03
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Granted: 1978-07-04
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Expires: 1997-01-03
Abstract
Abstract The present invention relates to new chemical compounds which can be used as inhibitors of dental plaque, and orally-acceptable compositions thereof, combinations thereof with known compounds having an inhibitory action on the formation of dental plaque, such as biguanidines, and method of treating therewith for the prevention of dental plaque or tartar and dental caries. The new compounds have the general formula ##STR1## in which R 1 = H or alkyl R 2 = ch 2 oh, alkyl carboxylate, ##STR2## and R 2 is in 2 or 3 position. Compositions containing these active principles are useful in particular in the preventive treatment of periodontopathies and odontopathies and in the field of oral-dental hygiene.
Inventors
- 👤 Henri Cousse
- 👤 Gilbert Mouzin
- 👤 Jean-Claude Vezin
- 👤 Lucien Dussourd d'Hinterland
- 👤 Jacques Dubois
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-28 16:47
CPC Classifications
C; C07; C07D; C07D213/00; C07D213/02; C07D213/04; C07D213/60; C07D213/78; C07D213/81; C07D213/82; A; A61; A61K; A61K8/00; A61K8/18; A61K8/30; A61K8/49; A61K8/4906; A61K8/4926; A61K8/69; A61Q; A61Q11/00; C07D213/24; C07D213/28; C07D213/30; C07D213/79; C07D213/80
Claims Analysis
Total Claims: 24
Claim 1
Independent Claim
36 words
A compound of formula ##STR14## in which R 1 = H or alkyl R 2 = ch 2 oh, in 2 or 3 position on the pyridyl ring, "alkyl" containing a maximum of twelve carbon atoms.
Claim 2
Dependent Claim
36 words
A compound of formula ##STR14## in which R 1 = H or alkyl R 2 = ch 2 oh, in 2 or 3 position on the pyridyl ring, "alkyl" containing a maximum of twelve carbon atoms.
Claim 3
Dependent Claim
19 words
A compound of claim 1 selected from the group consisting of: 3-pyridylmethanol hydrofluoride, N-dodecyl 3-pyridylmethanol fluoride, and 2-pyridylmethanol hydrofluoride.
Claim 4
Dependent Claim
8 words
Compound of claim 1 which is 3-pyridylmethanol hydrofluoride.
Claim 5
Dependent Claim
9 words
Compound of claim 1 which is N-dodecyl 3-pyridylmethanol fluoride.
Claim 6
Dependent Claim
8 words
Compound of claim 1 which is 2-pyridylmethanol hydrofluoride.
Claim 7
Dependent Claim
34 words
An oral and dental hygiene composition suitable for use in the inhibition of dental plaque comprising a compound of claim 1, in an amount effective for said purpose, in association with an orally-acceptable carrier.
Claim 8
Dependent Claim
34 words
An oral and dental hygiene composition suitable for use in the inhibition of dental plaque comprising a compound of claim 2, in an amount effective for said purpose, in association with an orally-acceptable carrier.
Claim 9
Dependent Claim
18 words
An antiplaque dentifrice preparation containing, as active principle, an effective amount of a product according to claim 1.
Claim 10
Dependent Claim
17 words
An antiplaque dentifrice preparation containing, as active principle, an effective amount of product according to claim 2.
Claim 11
Dependent Claim
25 words
Orally-acceptable antiplaque composition containing an effective amount of compound of claim 1 and a bactericidal chemical compound, having properties inhibiting the formation of dental plaque.
Claim 12
Dependent Claim
26 words
An anti-plaque composition according to claim 10, characterized in that the fluorinated compound is 3-pyridylmethanol hydrofluoride and the bactericidal compound is chlorhexidine or a salt thereof.
Claim 13
Dependent Claim
18 words
A composition according to claim 10 in the form of a mouthwash, paste, topical solution, or chewing gum.
Claim 14
Dependent Claim
18 words
A composition according to claim 12, characterized in that it is in the form of a dentifrice preparation.
Claim 15
Dependent Claim
18 words
An anti-plaque composition according to claim 10, containing 0.1 to 10 percent by weight of the active principles.
Claim 16
Dependent Claim
14 words
A composition according to claim 10, having a pH which is less than 7.
Claim 17
Dependent Claim
17 words
A composition according to claim 15, characterized in that pyroglutamic acid is included as an acidifying agent.
Claim 18
Dependent Claim
19 words
An anti-plaque composition according to claim 11, in the form of a dentifrice, chewing gum, tooth gel, or mouthwash.
Claim 19
Dependent Claim
23 words
An orally-acceptable antiplaque composition according to claim 6 in the form of a mouthwash, gum paste, chewing gum, dentifrice, gel, paste, or tablet.
Claim 20
Dependent Claim
23 words
An orally-acceptable antiplaque composition according to claim 7 in the form of a mouthwash, gum paste, chewing gum, dentifrice, gel, paste, or tablet.
Claim 21
Dependent Claim
33 words
An oral and dental hygiene composition suitable for use in the inhibition of dental plaque comprising a composition of claim 10, in an amount effective for said purpose, also including an orally-acceptable carrier.
Claim 22
Dependent Claim
40 words
Method for the inhibition of dental plaque, comprising the step of contacting a tooth or the oral cavity containing said tooth with a compound of claim 1 in an amount and for a period of time effective for said purpose.
Claim 23
Dependent Claim
40 words
Method for the inhibition of dental plaque, comprising the step of contacting a tooth or the oral cavity containing said tooth with a compound of claim 2 in an amount and for a period of time effective for said purpose.
Claim 24
Dependent Claim
40 words
Method for the inhibition of dental plaque, comprising the step of contacting a tooth or the oral cavity containing said tooth with a composition of claim 10 in an amount and for a period of time effective for said purpose.
References Cited (Backward Citations)
CA673101A
Cited
US3914406A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-07-03 | 1982-01-02 | 1982-07-04 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-07-03 | 1986-01-02 | 1986-07-04 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-07-03 | 1990-01-02 | 1990-07-04 | $7700.00 | Window Closed / Lapsed |