US4096337A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Prostane derivatives
Assignee: Mallinckrodt Veterinary Inc
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Filing: 1976-06-01
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Granted: 1978-06-20
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Expires: 1996-06-01
Abstract
Abstract The disclosure relates to novel 15-(3-aryl- or 3-aralkyl-cyclobutyl, -cyclopentyl and -cyclohexyl)- omega -pentanor prostaglandin analogues, for example 9 alpha ,11 alpha ,15 alpha -trihydroxy-15-(trans-3-phenylcyclobutyl)-16,17,18,19,20-pentanor-5-ci s,13-trans-prostadienoic acid, to pharmaceutical or veterinary compositions containing such a compound, and to a method of inducing luteolysis in animals by orally administering such a compound.
Inventors
- 👤 Peter Robert Marsham
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 16:19
CPC Classifications
C; C07; C07D; C07D307/00; C07D307/77; C07D307/93; C07D307/935; A; A61; A61P; A61P43/00; C07C; C07C405/00; C07D309/00; C07D309/02; C07D309/08; C07D309/10; C07D309/12; C07F; C07F9/00; C07F9/02; C07F9/28; C07F9/38; C07F9/40; C07F9/4003; C07F9/4006; C07F9/4018
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
114 words
A prostane derivative of the formula:- ##STR21## wherein R 1 is carboxy or C 2-5 alkoxycarbonyl, R 2 , R 5 and R 6 are each hydrogen, R 3 is hydroxy and R 4 is hydrogen, X is ethylene or cis-vinylene, Y is ethylene or trans-vinylene, R 7 is hydrogen or C 1-4 alkyl, R 8 is phenyl or naphthyl which is unsubstituted or is substituted by halogen, nitro, phenyl, or C 1-4 alkyl, halogenoalkyl or alkoxy, m and n, which may be the same or different, are each 1 or 2, and x is 0 or 1, and for those compounds wherein R 1 is carboxy, the pharmaceutically or veterinarily acceptable salts thereof.
Claim 2
Dependent Claim
114 words
A prostane derivative of the formula:- ##STR21## wherein R 1 is carboxy or C 2-5 alkoxycarbonyl, R 2 , R 5 and R 6 are each hydrogen, R 3 is hydroxy and R 4 is hydrogen, X is ethylene or cis-vinylene, Y is ethylene or trans-vinylene, R 7 is hydrogen or C 1-4 alkyl, R 8 is phenyl or naphthyl which is unsubstituted or is substituted by halogen, nitro, phenyl, or C 1-4 alkyl, halogenoalkyl or alkoxy, m and n, which may be the same or different, are each 1 or 2, and x is 0 or 1, and for those compounds wherein R 1 is carboxy, the pharmaceutically or veterinarily acceptable salts thereof.
Claim 3
Dependent Claim
111 words
The prostane derivative of claim 1 wherein R 1 is carboxy, methoxycarbonyl, ethoxycarbonyl or butoxycarbonyl, R 7 is hydrogen or methyl and R 8 is phenyl or naphthyl which is unsubstituted or bears one substituent selected froom chlorine, fluorine, bromine, nitro, phenyl, methyl, ethyl, propyl, butyl, trifluoromethyl, methoxy, ethoxy, propoxy and butoxy, and R 2 , R 3 , R 4 , R 5 , R 6 , X, Y, m, n and x have the meanings stated in claim 1, and for those compounds wherein R 1 is carboxy, the ammonium, alkylammonium containing 1 to 4 C 1-4 alkyls, alkanolammonium containing 1 to 3 2-hydroxyethyls, and alkali metal salts thereof.
Claim 4
Dependent Claim
68 words
The prostane derivative of claim 2 wherein R 1 is carboxy or methoxycarbonyl, R 8 is phenyl or naphthyl which is unsubstituted or bears one substituent selected from chlorine, fluorine, nitro, phenyl, methyl, trifluoromethyl and methoxy, and R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , X, Y, m, n and x have the meanings stated in claim 2.
Claim 5
Dependent Claim
22 words
The prostane derivative of claim 2 wherein R 1 is carboxy, which is an ammonium, triethylammonium, ethanolammonium, diethanolammonium, sodium or potassium salt.
Claim 6
Dependent Claim
65 words
The prostane derivative of claim 1 wherein R 1 is carboxy or methoxycarbonyl, R 2 , R 5 and R 6 are each hydrogen, X is cis-vinylene, Y is trans-vinylene, R 7 is hydrogen or methyl, m and n are each 1, x is 0, and R 8 is phenyl, which is unsubstituted or substituted by one chlorine, fluorine, methyl or trifluoromethyl, or unsubstituted naphthyl.
Claim 7
Dependent Claim
17 words
The prostane derivative of claim 5 wherein R 8 is phenyl, 3-trifluoromethylphenyl, 3-tolyl, 4-fluorophenyl, 4-chlorophenyl or 1-naphthyl.
Claim 8
Dependent Claim
3 words
9α,11α,15α-Trihydroxy-15-(trans-3-phenylcyclobutyl)-16,17,18,19,20-pentanor-5-cis, 13-trans-prostadienoic acid.
Claim 9
Dependent Claim
3 words
9α,11α,15α-Trihydroxy-15-(trans-3-phenylcyclobutyl)-16,17,18,19,20-pentanor-5-cis, 13-trans-prostadienoic acid.
Claim 10
Dependent Claim
24 words
A pharmaceutical or veterinary composition consisting essentially of the prostane derivative of claim 1 together with a pharmaceutically or veterinarily acceptable diluent or carrier.
Claim 11
Dependent Claim
28 words
A method of inducing luteolysis in mammals which comprises administering to mammals in need of such treatment a luteolytically effective amount of the prostane derivative of claim 1.
References Cited (Backward Citations)
DE2510818A1
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-06-19 | 1981-12-19 | 1982-06-20 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-06-19 | 1985-12-19 | 1986-06-20 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-06-19 | 1989-12-19 | 1990-06-20 | $7700.00 | Window Closed / Lapsed |