US4096335A
Expired / Lapsed
US
⏱️ 0.0 years remaining
16-Phenoxy prostaglandin B2 analogs
Assignee: Pharmacia and Upjohn Co
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Filing: 1977-02-07
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Granted: 1978-06-20
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Expires: 1997-02-07
Abstract
Abstract Prostaglandin-type compounds with a phenoxy or substituted-phenoxy substituent at the C-16 position are disclosed, with processes for making them. These compounds are useful for a variety of pharmacological purposes, including anti-ulcer, inhibition of platelet aggregation, increase of nasal patency, labor inducement at term, and wound healing.
Inventors
- 👤 Norman A. Nelson
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 19:34
CPC Classifications
C; C07; C07D; C07D307/00; C07D307/77; C07D307/93; C07D307/935; C07C; C07C405/00; C07D309/00; C07D309/02; C07D309/08; C07D309/10; C07D309/12; C07F; C07F9/00; C07F9/02; C07F9/28; C07F9/38; C07F9/40; C07F9/4003; C07F9/4006
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
164 words
An optically active compound of the formula or a racemic compound of that formula and the mirror image thereof, wherein g is an integer from 2 to 5, inclusive; wherein M is ##STR11## wherein R 1 is hydrogen or alkyl of one to 12 carbon atoms, inclusive, cycloalkyl of 3 to 10 carbon atoms, inclusive, aralkyl of 7 to 12 carbon atoms, inclusive, phenyl, or phenyl substituted with one, 2, or 3 chloro or alkyl of one to 4 carbon atoms, inclusive; wherein R 2 and R 3 are hydrogen, methyl, or ethyl; wherein T is alkyl of one to 3 carbon atoms, inclusive, fluoro, chloro, trifluoromethyl, or --OR 4 wherein R 4 is alkyl of one to 3 carbon atoms, inclusive, and wherein s is zero, one, 2, or 3, with the proviso that not more than two T's are other than alkyl; including each of the lower monoalkanoates thereof, and each of the pharmacologically acceptable salts thereof when R 1 is hydrogen.
Claim 2
Dependent Claim
164 words
An optically active compound of the formula or a racemic compound of that formula and the mirror image thereof, wherein g is an integer from 2 to 5, inclusive; wherein M is ##STR11## wherein R 1 is hydrogen or alkyl of one to 12 carbon atoms, inclusive, cycloalkyl of 3 to 10 carbon atoms, inclusive, aralkyl of 7 to 12 carbon atoms, inclusive, phenyl, or phenyl substituted with one, 2, or 3 chloro or alkyl of one to 4 carbon atoms, inclusive; wherein R 2 and R 3 are hydrogen, methyl, or ethyl; wherein T is alkyl of one to 3 carbon atoms, inclusive, fluoro, chloro, trifluoromethyl, or --OR 4 wherein R 4 is alkyl of one to 3 carbon atoms, inclusive, and wherein s is zero, one, 2, or 3, with the proviso that not more than two T's are other than alkyl; including each of the lower monoalkanoates thereof, and each of the pharmacologically acceptable salts thereof when R 1 is hydrogen.
Claim 3
Dependent Claim
10 words
A compound according to claim 1 wherein "g" is 3.
Claim 4
Dependent Claim
10 words
A compound according to claim 2 wherein "M" is ##STR12##
Claim 5
Dependent Claim
15 words
A compound according to claim 3 wherein both R 2 and R 3 are hydrogen.
Claim 6
Dependent Claim
9 words
16-Phenoxy-17,18,19,20-tetranor-PGB 2 , a compound according to claim 4.
Claim 7
Dependent Claim
14 words
A compound according to claim 4 wherein "T" is trifluoromethyl and "s" is one.
Claim 8
Dependent Claim
17 words
A compound according to claim 3 wherein one or both R 2 and R 3 are methyl.
Claim 9
Dependent Claim
9 words
16-Methyl-16-phenoxy-18,19,20-trinor-PGB 2 , a compound according to claim 7.
Claim 10
Dependent Claim
14 words
A compound according to claim 7 wherein "T" is trifluoromethyl and "s" is one.
Claim 11
Dependent Claim
9 words
16-Methyl-16-phenoxy-2a,2b-dihomo-18,19,20-trinor-PGB 2 , a compound according to claim 1.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-06-19 | 1981-12-19 | 1982-06-20 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-06-19 | 1985-12-19 | 1986-06-20 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-06-19 | 1989-12-19 | 1990-06-20 | $7700.00 | Window Closed / Lapsed |