US4096279A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Ethynylbenzene compounds and derivatives thereof in the treatment of pain fever and inflammation
Assignee: William H Rorer Inc
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Filing: 1977-01-11
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Granted: 1978-06-20
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Expires: 1997-01-11
Abstract
Abstract A method of treating patients by administering an effective amount of a compound which is an amino, acylamino, acetyl, or mono or diloweralkyl amino ethynylbenzene, and the pharmaceutical preparation thereof.
Inventors
- 👤 Julius Diamond
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 06:37
CPC Classifications
C; C07; C07C; C07C205/00; C07C205/49; C07C205/56
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
132 words
A method of treating inflammation, pain or fever in a warm blooded animal which comprises administering to the animal an effective amount of an active agent which is a compound of the formula: ##STR8## where R is hydrogen, alkyl of 1 to 7 carbon atoms, cycloalkyl of 5 to 7 carbon atoms, 1to 7 carbon atoms alkyl substituted cycloalkyl of 5 to 7 carbon atoms, cycloalkenyl of 5 to 7 atoms, phenyl or substituted phenyl where the substituent is Y"; Y and Y' are each selected from the group consisting of hydrogen, amino, and mono and diloweralkylamino; Y" is selected from the group consisting of Y, lower alkyl of 1 to 7 carbon atoms, trifluoromethyl and halo, with the proviso that at least one of Y and Y' is other than hydrogen.
Claim 2
Independent Claim
132 words
A method of treating inflammation, pain or fever in a warm blooded animal which comprises administering to the animal an effective amount of an active agent which is a compound of the formula: ##STR8## where R is hydrogen, alkyl of 1 to 7 carbon atoms, cycloalkyl of 5 to 7 carbon atoms, 1to 7 carbon atoms alkyl substituted cycloalkyl of 5 to 7 carbon atoms, cycloalkenyl of 5 to 7 atoms, phenyl or substituted phenyl where the substituent is Y"; Y and Y' are each selected from the group consisting of hydrogen, amino, and mono and diloweralkylamino; Y" is selected from the group consisting of Y, lower alkyl of 1 to 7 carbon atoms, trifluoromethyl and halo, with the proviso that at least one of Y and Y' is other than hydrogen.
Claim 3
Dependent Claim
12 words
A method according to claim 1 wherein the active agent is 3-dimethylamino-4-cyclohexylethynylbenzene.
Claim 4
Dependent Claim
12 words
A method according to claim 1 wherein the active agent is 3-chloro-5-amino-4-cycloheptylethynylbenzene.
Claim 5
Dependent Claim
12 words
A method according to claim 1 wherein the active agent is 3-amino-4-cyclohexylethynylbenzene.
Claim 6
Dependent Claim
12 words
A method according to claim 1 wherein the active agent is 3-methylamino-4-cyclohexylethynylbenzene.
Claim 7
Dependent Claim
138 words
A pharmaceutical preparation in a dosage unit form adapted for administration to warm-blooded animals for the treatment of inflammation, pain or fever, comprising an effective amount of a compound of the formula ##STR9## where R is hydrogen, alkyl of 1 to 7 carbon atoms, cycloalkyl of 5 to 7 carbon atoms 1to 7 carbon atoms alkyl substituted cycloalkyl of 5 to 7 carbon atoms, cycloalkenyl of 5 to 7 carbon atoms, phenyl or substituted phenyl where the substituent is Y"; Y and Y' are each selected from the group consisting of hydrogen, amino, and mono and diloweralkylamino, Y" is selected from the group consisting of Y, lower alkyl of 1 to 7 carbon atoms, trifluoromethyl and halo, with the proviso that at least one of Y and Y' is other than hydrogen, and a suitable pharmaceutically acceptable carrier.
Claim 8
Dependent Claim
138 words
A pharmaceutical preparation in a dosage unit form adapted for administration to warm-blooded animals for the treatment of inflammation, pain or fever, comprising an effective amount of a compound of the formula ##STR9## where R is hydrogen, alkyl of 1 to 7 carbon atoms, cycloalkyl of 5 to 7 carbon atoms 1to 7 carbon atoms alkyl substituted cycloalkyl of 5 to 7 carbon atoms, cycloalkenyl of 5 to 7 carbon atoms, phenyl or substituted phenyl where the substituent is Y"; Y and Y' are each selected from the group consisting of hydrogen, amino, and mono and diloweralkylamino, Y" is selected from the group consisting of Y, lower alkyl of 1 to 7 carbon atoms, trifluoromethyl and halo, with the proviso that at least one of Y and Y' is other than hydrogen, and a suitable pharmaceutically acceptable carrier.
Claim 9
Dependent Claim
12 words
A preparation according to claim 6 wherein the active agent is 3-dimethylamino-4-cyclohexylethynylbenzene.
Claim 10
Dependent Claim
12 words
A preparation according to claim 6 wherein the active agent is 3-chloro-5-amino-4-cycloheptylethynylbenzene.
Claim 11
Dependent Claim
12 words
A preparation according to claim 6 wherein the active agent is 3-amino-4-cyclohexylethynylbenzene.
Claim 12
Dependent Claim
12 words
A preparation according to claim 6 wherein the active agent is 3-methylamino-4-cyclohexylethynylbenzene.
References Cited (Backward Citations)
US3952067A
Cited
US4016214A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-06-19 | 1981-12-19 | 1982-06-20 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-06-19 | 1985-12-19 | 1986-06-20 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-06-19 | 1989-12-19 | 1990-06-20 | $7700.00 | Window Closed / Lapsed |