US4096270A
Expired / Lapsed
US
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4-(2-Chloro- or methylthiopyrid-3-yl)-3,5-dicarbalkoxy-2,6-dimethyl-1,4-dihydropyridine
Assignee: Hexachimie SA
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Filing: 1976-08-05
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Granted: 1978-06-20
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Expires: 1996-08-05
Abstract
Abstract This invention relates to substituted 1,4-dihydropyridines showing interesting physiological activities, particularly on the cardiovascular system. 1,4-Dihydropyridines in accordance with the invention are substituted in the 4-position by a 2-chloropyrid-3-yl or a 2-methylthiopyrid-3-yl group, in the 3- and 5-positions by a methoxycarbonyl or ethoxycarbonyl group and in the 2- and 6-positions by a methyl group. Acid addition salts of these compounds are included in the present invention. The compounds can be prepared by reacting an appropriate 2-substituted nicotinaldehyde with an alkyl acetoacetate. Compounds in accordance with the invention have shown anti-hypertensive activity at very low doses.
Inventors
- 👤 Jean-Marie Teulon
- 👤 Bernard Schweisguth
- 👤 Jean-Claude Cognacq
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 05:18
CPC Classifications
C; C07; C07D; C07D213/00; C07D213/02; C07D213/04; C07D213/60; C07D213/62; C07D213/70; A; A61; A61P; A61P9/00; A61P9/08; A61P9/10; A61P9/12; C07D401/00; C07D401/02; C07D401/04
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
49 words
A compound of the formula ##STR4## wherein X is selected from the group consisting of a chlorine atom and a CH 3 S group, and each of the groups R 1 is the same and represents a methyl or ethyl group, or a physiologically acceptable acid addition salt thereof.
Claim 2
Dependent Claim
49 words
A compound of the formula ##STR4## wherein X is selected from the group consisting of a chlorine atom and a CH 3 S group, and each of the groups R 1 is the same and represents a methyl or ethyl group, or a physiologically acceptable acid addition salt thereof.
Claim 3
Dependent Claim
9 words
4-(2-Chloropyrid-3-yl)-3,5-dicarbomethoxy-2,6-dimethyl-1,4-dihydropyridine or a physiologically acceptable acid addition salt thereof.
Claim 4
Dependent Claim
9 words
4-(2-Chloropyrid-3-yl)-3,5-dicarbomethoxy-2,6-dimethyl-1,4-dihydropyridine or a physiologically acceptable acid addition salt thereof.
Claim 5
Dependent Claim
8 words
The compound of claim 1 which is 4-(2-chloropyrid-3-yl)-3,5-dicarbethoxy-2,6-dimethyl-1,4-dihydropyridine.
Claim 6
Dependent Claim
8 words
The compound of claim 1 which is 4-(2-methylthiopyrid-3-yl)-3,5-dicarbethoxy-2,6-dimethyl-1,4-dihydropyridine.
Claim 7
Dependent Claim
26 words
A pharmaceutical composition for the treatment of hypertension comprising an effective amount of a compound as claimed in claim 1 and a pharmaceutical carrier or excipient.
Claim 8
Dependent Claim
13 words
A composition as claimed in claim 5, in the form of dosage units.
Claim 9
Dependent Claim
25 words
A method for treating a human suffering from hypertension comprising administering orally or parenterally an effective amount of a compound as claimed in claim 1.
References Cited (Backward Citations)
US3773773A
Cited
US3799934A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-06-19 | 1981-12-19 | 1982-06-20 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-06-19 | 1985-12-19 | 1986-06-20 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-06-19 | 1989-12-19 | 1990-06-20 | $7700.00 | Window Closed / Lapsed |