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US4096148A
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Oxazolidinedione derivatives of Vinca alkaloids
Assignee: Eli Lilly and Co
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Filing: 1976-12-06
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Granted: 1978-06-20
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Expires: 1996-12-06
Abstract
Abstract 3-Spiro-5"-oxazolidine-2",4"-dione derivatives of Vinca alkaloids, useful as anti-tumor agents and as intermediates.
Inventors
- 👤 Jean C. Miller
- 👤 Gerald E. Gutowski
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 03:26
CPC Classifications
C; C07; C07D; C07D519/00; C07D519/04; A; A61; A61P; A61P35/00
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
97 words
A compound of the formula ##STR5## wherein R is H, C 1 -C 4 alkyl, C 3 -C 4 alkenyl, CH 2 --CHX--CH 3 or CH 2 --CH 2 X; wherein X is Br or Cl; R 1 is OH, ##STR6## R 2 is H, CH 3 or CHO; one of R 3 and R 4 , when taken singly, is H or OH and the other C 2 H 5 ; R 5 , when taken singly, is H; and R 4 and R 5 , when taken together, form an epoxide; and pharmaceutically-acceptable salts thereof.
Claim 2
Dependent Claim
97 words
A compound of the formula ##STR5## wherein R is H, C 1 -C 4 alkyl, C 3 -C 4 alkenyl, CH 2 --CHX--CH 3 or CH 2 --CH 2 X; wherein X is Br or Cl; R 1 is OH, ##STR6## R 2 is H, CH 3 or CHO; one of R 3 and R 4 , when taken singly, is H or OH and the other C 2 H 5 ; R 5 , when taken singly, is H; and R 4 and R 5 , when taken together, form an epoxide; and pharmaceutically-acceptable salts thereof.
Claim 3
Dependent Claim
11 words
A compound according to claim 1, said compound being VLB 3"-methyl-3-spiro-5"-oxazolidine-2",4"-dione.
Claim 4
Dependent Claim
9 words
The sulfate salt of the compound of claim 2.
Claim 5
Dependent Claim
11 words
A compound according to claim 1 said compound being VLB 3"-(β-chloroethyl)-3-spiro-5"-oxazolidine-2",4"-dione.
Claim 6
Dependent Claim
9 words
The sulfate salt of the compound of claim 4.
Claim 7
Dependent Claim
11 words
A compound according to claim 1 wherein R 1 is OH.
Claim 8
Dependent Claim
11 words
A compound according to claim 1 wherein R 1 is ##STR7##
References Cited (Backward Citations)
US3311655A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-06-19 | 1981-12-19 | 1982-06-20 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-06-19 | 1985-12-19 | 1986-06-20 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-06-19 | 1989-12-19 | 1990-06-20 | $7700.00 | Window Closed / Lapsed |