US4094966A
Expired / Lapsed
US
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Iodobenzene derivatives and x-ray contrast media containing the same
Assignee: Laboratoires Andre Guerbet
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Filing: 1976-12-07
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Granted: 1978-06-13
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Expires: 1996-12-07
Abstract
Abstract The present invention provides new iodobenzene derivatives which have at least two benzene nuclei and one carboxylic group. These derivatives possess a low toxicity and may be used as X-ray contrast media.
Inventors
- 👤 Guy Tilly
- 👤 Michel Jean Charles Hardouin
- 👤 Jean Lautrou
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 16:22
CPC Classifications
C; C07; C07D; C07D209/00; C07D209/02; C07D209/44; C07D209/48; A; A61; A61K; A61K49/00; A61K49/04; A61K49/0433
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
242 words
An iodobenzene derivative selected from the group consisting of a compound of formula ##STR113## in which: R 1 is selected from the group consisting of hydrogen, a radical having the formula ##STR114## R 5 and R 6 being selected from the group consisting of hydrogen, lower alkyl and lower hydroxy alkyl, and a radical of the formula ##STR115## R 7 being a lower alkanoyl radical and R 8 being selected from the group consisting of hydrogen, lower alkyl and lower hydroxylakyl, R 2 is selected from the group consisting of hydrogen, a radical having the formula ##STR116## in which R 9 and R 10 have the meanings given for R 5 and R 6 , and a radical of the formula ##STR117## in which 11 has the meaning given for R 7 or represents a hydrogen atom and R 12 has the meaning given for R 8 , R 3 is selected from the group consisting of hydrogen, a radical having the formula ##STR118## in which R 13 and R 14 have the meanings given for R 5 and R 6 , and a radical of the formula ##STR119## in which R 15 has the meaning given for R 7 or represents hydrogen and R 16 has the meaning given for R 8 , R 4 is selected from the group consisting of hydrogen, lower alkyl and lower hydroxylakyl, a lower alkyl ester thereof and a salt with a pharmaceutically acceptable base.
Claim 2
Dependent Claim
242 words
An iodobenzene derivative selected from the group consisting of a compound of formula ##STR113## in which: R 1 is selected from the group consisting of hydrogen, a radical having the formula ##STR114## R 5 and R 6 being selected from the group consisting of hydrogen, lower alkyl and lower hydroxy alkyl, and a radical of the formula ##STR115## R 7 being a lower alkanoyl radical and R 8 being selected from the group consisting of hydrogen, lower alkyl and lower hydroxylakyl, R 2 is selected from the group consisting of hydrogen, a radical having the formula ##STR116## in which R 9 and R 10 have the meanings given for R 5 and R 6 , and a radical of the formula ##STR117## in which 11 has the meaning given for R 7 or represents a hydrogen atom and R 12 has the meaning given for R 8 , R 3 is selected from the group consisting of hydrogen, a radical having the formula ##STR118## in which R 13 and R 14 have the meanings given for R 5 and R 6 , and a radical of the formula ##STR119## in which R 15 has the meaning given for R 7 or represents hydrogen and R 16 has the meaning given for R 8 , R 4 is selected from the group consisting of hydrogen, lower alkyl and lower hydroxylakyl, a lower alkyl ester thereof and a salt with a pharmaceutically acceptable base.
Claim 3
Dependent Claim
19 words
An iodobenzene derivative selected from 2,4,6-tri-iodo-3-N-methylcarbamyl-5-bis {[2,4,6-triiodo-3,5-bis (N-hydroxyethylcarbamyl-phenyl]carbamyl-methyl} aminoacetamidobenzoic acid and a salt thereof with a pharmaceutically acceptable base.
Claim 4
Dependent Claim
19 words
An iodobenzene derivative selected from 2,4,6-tri-iodo-3-N-methylcarbamyl-5-bis {[2,4,6-triiodo-3,5-bis (N-hydroxyethylcarbamyl-phenyl]carbamyl-methyl} aminoacetamidobenzoic acid and a salt thereof with a pharmaceutically acceptable base.
Claim 5
Dependent Claim
20 words
An iodobenzene derivative selected from 2,4,6-triiodo-3-N-methylacetamido-5-bis {[2,4,6-triiodo-3,5-bis (N-hydroxyethyl-carbamyl)-phenyl] carbamyl-methyl} aminoacetamidobenzoic acid and a salt thereof with a pharmaceutically acceptable base.
Claim 6
Dependent Claim
20 words
An iodobenzene derivative selected from 2,4,6-triiodo-3-N-methylacetamido-5-bis {[2,4,6-triiodo-3,5-bis (N-hydroxyethyl-carbamyl)-phenyl] carbamyl-methyl} aminoacetamidobenzoic acid and a salt thereof with a pharmaceutically acceptable base.
Claim 7
Dependent Claim
19 words
An iodobenzene derivative selected from 2,4,6-triiodo-3-N-methylcarbamyl-5-bis {[2,4,6-triiodo-3,5-bis (N-hydroxyethyl-carbamyl)-phenyl]carbamyl-methyl} amino-N-methylacetamido-benzoic acid and a salt thereof with a pharmaceutically acceptable base.
Claim 8
Dependent Claim
19 words
An iodobenzene derivative selected from 2,4,6-triiodo-3-N-methylcarbamyl-5-bis {[2,4,6-triiodo-3,5-bis (N-hydroxyethyl-carbamyl)-phenyl]carbamyl-methyl} amino-N-methylacetamido-benzoic acid and a salt thereof with a pharmaceutically acceptable base.
Claim 9
Dependent Claim
20 words
An X-ray contrast mdium comprising an aqueous solution of an effective amount of a compound as claimed in claim 1.
Claim 10
Dependent Claim
25 words
An X-ray contrast medium comprising an aqueous solution of an effective amount of a pharmacologically acceptable salt of a compound as claimed in claim 1.
Claim 11
Dependent Claim
22 words
An X-ray contrast medium as claimed in claim 6 in which 100 ml of said solution contains 5-100 g of said salt.
References Cited (Backward Citations)
US3666760A
Cited
US3781338A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-06-12 | 1981-12-12 | 1982-06-13 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-06-12 | 1985-12-12 | 1986-06-13 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-06-12 | 1989-12-12 | 1990-06-13 | $7700.00 | Window Closed / Lapsed |