US4089946A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Claudogenic-interceptive nonapeptides
Assignee: Wyeth LLC
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Filing: 1976-06-07
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Granted: 1978-05-16
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Expires: 1996-06-07
Abstract
Abstract Compounds of the formula: L-p-Glu-L-His-L-Trp-L-Ser-L-Tyr-X-Y-L-Arg-L-Pro-NHC.sub.2 H.sub.5 in which X is D-Trp or D-2-(1,4-cyclohexadienyl)Gly Y is L-(N-methyl)-Leu or L-(N-methyl)-ILe or a non-toxic acid addition salt thereof, are potent ovulation inducers and claudogenic-interceptive agents useful in preventing or terminating pregnancy in mammals.
Inventors
- 👤 Theodore J. Foell
- 👤 Richard W. Rees
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 23:02
CPC Classifications
C; C07; C07K; C07K7/00; C07K7/04; C07K7/23; A; A61; A61K; A61K38/00; Y; Y10; Y10S; Y10S930/00; Y10S930/01; Y10S930/13
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
14 words
The compound of the formula: L-p-Glu-L-His-L-Trp-L-Ser-L-Tyr-D-Trp-L-(N-methyl)Leu-L-Arg-L-Pro-NHC.sub.2 H.sub.5 or a non-toxic acid addition salt thereof.
Claim 2
Dependent Claim
14 words
The compound of the formula: L-p-Glu-L-His-L-Trp-L-Ser-L-Tyr-D-Trp-L-(N-methyl)Leu-L-Arg-L-Pro-NHC.sub.2 H.sub.5 or a non-toxic acid addition salt thereof.
Claim 3
Independent Claim
54 words
A method for terminating pregnancy in a female mammal which comprises administering a nonapeptide of the formula: L-p-Glu-L-His-L-Trp-Ser-L-Tyr-D-Trp-L-(N-methyl)Leu-L-Arg-L-Pro-NHC.sub.2 H.sub.5, or a pharmaceutically acceptable acid addition salt thereof, to said mammal, post coitally, in a daily regimen containing at least about 3 micrograms per kilogram host body weight for a time sufficient to terminate pregnancy.
Claim 4
Independent Claim
54 words
A method for terminating pregnancy in a female mammal which comprises administering a nonapeptide of the formula: L-p-Glu-L-His-L-Trp-Ser-L-Tyr-D-Trp-L-(N-methyl)Leu-L-Arg-L-Pro-NHC.sub.2 H.sub.5, or a pharmaceutically acceptable acid addition salt thereof, to said mammal, post coitally, in a daily regimen containing at least about 3 micrograms per kilogram host body weight for a time sufficient to terminate pregnancy.
Claim 5
Dependent Claim
37 words
The method of claim 2 in which said nonapeptide is administered, orally or parenterally, to said mammal following a daily regimen beginning on day one after coitus and extending through about the first eight days post implantation.
Claim 6
Dependent Claim
32 words
The method of claim 2 in which said nonapeptide is administered, orally or parenterally, following a daily regimen beginning on day one after coitus and extending through about day seven post coitus.
References Cited (Backward Citations)
US3992365A
Cited
US3992530A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-05-15 | 1981-11-14 | 1982-05-16 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-05-15 | 1985-11-14 | 1986-05-16 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-05-15 | 1989-11-14 | 1990-05-16 | $7700.00 | Window Closed / Lapsed |