6-(P-PIPERAZINO)-PHENYL-4,5-DIHYDRO-3(2H)pyridazinones

Abstract

Abstract Compounds of the general formula: ##STR1## in which X represents A STRAIGHT OR BRANCHED CHAIN ALKYL OR ALKOXY GROUP, A hydroxymethyl group, A cycloalkoxy group, A hydroxyl group, A chlorine atom, A piperidino group, A pyrrolidino group A cycloalkyl group, An aryloxy group, A fluorine atom, An amino or substituted amino group, A morpholino group, A 1,2,3,6-tetrahydropyridino group, A 4-[3-azabicyclo(3,2,2)-nonyl] group, or a 4-(piperazin-1-yl) or 4-(4-substituted-piperazin-1-yl) group of the formula ##STR2## in which R═H, lower alkyl of 1-5 carbon atoms, aryl, substituted aryl, aralkyl, cinnamyl, acyl, ethoxy-carbonyl, aroyl or substituted aroyl and n is an integer from 1 to 5 except that when n is 1 X is not an alkyl group of 1 to 3 carbon atoms or an alkoxy group of 1 or 2 carbon atoms or a chlorine atom in the 4'-position, or an amino or acylated amino group in positions 2', 3' or 4'; and when n= 2 the groups X cannot both be methyl or both be methoxy in the 2' and 5' positions, nor can X be a chlorine atom in both the 2' and 4' positions or the 3' and 4' positions, and when n= 3, X cannot all three be methoxy. These compounds have anti-hypertensive activity.

Inventors

• 👤 Mehmood A. Hakim
• 👤 Peter T. Bysouth

Bibliographic Details