Pharmaceutical composition and process of treatment

Claim 1

A process for treating proliferative skin diesases which comprises administering to the afflicted human or animal a composition comprising at least two active compounds in association with a pharmaceutical carrier, said compounds being present in an amount in the range of about 0.1% to about 10% w/v which is effective to alleviate a proliferative skin disease, at least one of said compounds being selected from a first group consisting of adenosine, 2'-deoxyadenosine, 2',3'-isopropylidene adenosine, toyocamycin, 1-methyladenosine, N-6-methyladenosine, adenosine N-oxide, 6-methylmercaptopurine riboside, 6-chloropurine riboside, 5'-adenosine monophosphate, and at least one of said compounds being selected from a second group consisting of papaverine, diazepam, 1-ethyl-4-(isopropylidenehydrazino)-l H -pyrazolo-(3,4-b)-pyridine-5-carboxylic acid, ethyl ester, HCl, and a compound having the formula: ##STR10## wherein R is halogen, hydrogen, lower alkyl and lower alkoxy; R 2 , R 3 and R 4 taken independently of each other are hydrogen, lower alkoxy or hydroxy-lower alkoxy and provided that R 2 , R 3 and R 4 taken independently of each other represent at least one oxygenated substituent; R, R 2 , R 3 and R 4 taken as an adjacent pair is methylenedioxy and the optical antipodes thereof.