US4087613A
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US
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1,3,5- Or 1,3,6-naphthalenetriyltris(sulfonylimino)aryl acids and salts
Assignee: Wyeth Holdings LLC
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Filing: 1977-03-28
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Granted: 1978-05-02
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Expires: 1997-03-28
Abstract
Abstract 1,3,5- or 1,3,6-naphthalenetriyltris(sulfonylimino)aryl acids and salts, useful as complement inhibitors, and 1,3,5- or 1,3,6-naphthalenetriyltris(sulfonylimino)aryl acid esters which are intermediates, and the method for their preparation.
Inventors
- 👤 Ransom Brown Conrow
- 👤 Seymour Bernstein
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-30 01:34
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/185; A61K31/19; A61K31/195; C; C07; C07C; C07C311/00; C07C311/15
Claims Analysis
Total Claims: 27
Claim 1
Independent Claim
93 words
A compound of the formula: ##STR6## wherein R 1 is selected from the group consisting of hydrogen and methyl; R 2 is selected from the group consisting of hydrogen, carboxyl and COOR 4 , wherein R 4 is selected from the group consisting of alkali metal and alkaline earth metal; R 3 is selected from the group consisting of hydrogen, hydroxy and COOR 4 , wherein R 4 is as previously defined; with the proviso that each phenyl must contain at least one COOR 4 ; or another nontoxic pharmaceutically acceptable salt thereof.
Claim 2
Dependent Claim
93 words
A compound of the formula: ##STR6## wherein R 1 is selected from the group consisting of hydrogen and methyl; R 2 is selected from the group consisting of hydrogen, carboxyl and COOR 4 , wherein R 4 is selected from the group consisting of alkali metal and alkaline earth metal; R 3 is selected from the group consisting of hydrogen, hydroxy and COOR 4 , wherein R 4 is as previously defined; with the proviso that each phenyl must contain at least one COOR 4 ; or another nontoxic pharmaceutically acceptable salt thereof.
Claim 3
Dependent Claim
27 words
A compound according to claim 1, wherein each phenyl is only mono-substituted from the group consisting of COOR 4 , wherein R 4 is as previously defined.
Claim 4
Dependent Claim
27 words
A compound according to claim 1, wherein each phenyl is only di-substituted from the group consisting of COOR 4 , wherein R 4 is as previously defined.
Claim 5
Dependent Claim
27 words
A compound according to claim 1, wherein each phenyl is only tri-substituted from the group consisting of COOR 4 , wherein R 4 is as previously defined.
Claim 6
Dependent Claim
31 words
A compound according to claim 2, wherein each phenyl is only mono-substituted at the carbon 3-position or carbon 4-position and the floating phenyl is at the carbon 6-position on the naphthalene.
Claim 7
Dependent Claim
28 words
A compound according to claim 3, wherein each phenyl is only di-substituted at the carbon 3,5-position and the floating phenyl is at the carbon 6-position on the naphthalene.
Claim 8
Dependent Claim
18 words
A compound according to claim 4, wherein the floating phenyl is at the carbon 6-position on the naphthalene.
Claim 9
Dependent Claim
8 words
The compound according to claim 1, 5,5',5"-[1,3,6-naphthalenetriyltris(sulfonylimino)]tris[2-hydroxyisophthalic acid].
Claim 10
Dependent Claim
10 words
The compound according to claim 1, 5,5',5"-[1,3,6-naphthalenetriyltris(sulfonylimino)]triisophthalic acid hexasodium salt.
Claim 11
Dependent Claim
8 words
The compound according to claim 1, 3,3',3"-[1,3,6-naphthalenetriyltris(sulfonylimino)]tris[6-hydroxybenzoic acid].
Claim 12
Dependent Claim
10 words
The compound according to claim 1, 4,4',4"-[1,3,6-naphthalenetriyltris(sulfonylimino)]tribenzoic acid trisodium salt.
Claim 13
Dependent Claim
10 words
The compound according to claim 1, 5,5',5"-[1,3,6-naphthalenetriyltris(sulfonylimino)]tri-1,2,3-benzenetricarboxylic acid nonasodium salt.
Claim 14
Dependent Claim
10 words
The compound according to claim 1, 3,3',3"-[1,3,6-naphthalenetriyltris(sulfonylimino)]tribenzoic acid trisodium salt.
Claim 15
Dependent Claim
8 words
The compound according to claim 1, 5,5',5"-[1,3,6-naphthalenetriyltris(sulfonylimino)triisophthalic acid.
Claim 16
Dependent Claim
10 words
The compound according to claim 1, 5,5',5"-[1,3,6-naphthalenetriyltris(sulfonylmethylimino)]triisophthalic acid hexasodium salt.
Claim 17
Dependent Claim
66 words
A compound of the formula: ##STR7## wherein R 5 is selected from the group consisting of hydrogen and methyl; R 6 is selected from the group consisting of hydrogen, methoxycarbonyl, 2-methoxyethoxycarbonyl and phenoxycarbonyl; R 7 is selected from the group consisting of hydrogen, hydroxy, methoxycarbonyl and phenoxycarbonyl; and with the proviso that when R 6 is hydrogen, then R 7 may not be hydrogen or hydroxy.
Claim 18
Dependent Claim
66 words
A compound of the formula: ##STR7## wherein R 5 is selected from the group consisting of hydrogen and methyl; R 6 is selected from the group consisting of hydrogen, methoxycarbonyl, 2-methoxyethoxycarbonyl and phenoxycarbonyl; R 7 is selected from the group consisting of hydrogen, hydroxy, methoxycarbonyl and phenoxycarbonyl; and with the proviso that when R 6 is hydrogen, then R 7 may not be hydrogen or hydroxy.
Claim 19
Dependent Claim
12 words
A compound according to claim 16, wherein each phenyl is only tri-substituted.
Claim 20
Dependent Claim
29 words
A compound according to claim 17, wherein said phenyl is only tri-substituted with either 2-methoxyethoxycarbonyl or phenoxycarbonyl and the floating phenyl is at the carbon 6-position of the naphthalene.
Claim 21
Dependent Claim
9 words
The compound according to claim 16, 5,5',5"-[1,3,6-naphthalenetriyltris(sulfonylimino)]tris[2-hydroxyisophthalic acid]hexamethyl ester.
Claim 22
Dependent Claim
9 words
The compound according to claim 16, 5,5',5"-[1,3,6-naphthalenetriyltris(sulfonylimino)]triisophthalic acid hexakis(2-methoxyethyl)ester.
Claim 23
Dependent Claim
9 words
The compound according to claim 16, 3,3',3"-[1,3,6-naphthalenetriyltris(sulfonylimino)]tris[6-hydroxybenzoic acid]trimethyl ester.
Claim 24
Dependent Claim
10 words
The compound according to claim 16, 4,4',4"-[1,3,6-naphthalenetriyltris(sulfonylimino)]tribenzoic acid trimethyl ester.
Claim 25
Dependent Claim
10 words
The compound according to claim 16, 5,5',5"-[1,3,6-naphthalenetriyltris(sulfonylimino)]tri-1,2,3-benzenetricarboxylic acid nonaphenyl ester.
Claim 26
Dependent Claim
10 words
The compound according to claim 16, 3,3',3"-[1,3,6-naphthalenetriyltris(sulfonylimino)]tribenzoic acid trimethyl ester.
Claim 27
Dependent Claim
9 words
The compound according to claim 16, 5,5',5"-[1,3,6-naphthalenetriyltris(sulfonylmethylimino)]triisophthalic acid hexakis(2-methoxyethyl)ester.
References Cited (Backward Citations)
US3574169A
Cited
US3936479A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-05-01 | 1981-10-31 | 1982-05-02 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-05-01 | 1985-10-31 | 1986-05-02 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-05-01 | 1989-10-31 | 1990-05-02 | $7700.00 | Window Closed / Lapsed |