US4087487A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Carriers for biologically active compounds and methods for the production thereof
Assignee: Czech Academy of Sciences
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Filing: 1976-03-26
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Granted: 1978-05-02
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Expires: 1996-03-26
Abstract
Abstract There is disclosed a method for the production of carriers for biologically active compounds comprising forming a bond by admixing (a) a three dimensional water insoluble diazotizable polymer operative to function as a primary carrier and (b) a water soluble linear polymer having ligands operative to bind said biologically active compounds and operative to function as a secondary carrier, whereby the union of (a) and (b) is operative to serve as a carrier for biologically active compounds and carriers produced in accordance therewith.
Inventors
- 👤 Otto Wichterle
- 👤 Jiri Coupek
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-02 21:51
CPC Classifications
C; C08; C08G; C08G81/00; A; A01; A01N; A01N25/00; A01N25/08; A01N25/10
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
165 words
A method for the production of carriers for binding biologically active compounds comprising admixing (a) a primary component comprising a three-dimensional water insoluble polymer of components: (i) at least one monomer selected from the group consisting of lower alkyl acrylates and methacrylates, lower hydroxyalkyl acrylates and methacrylates and diethylene glycol and glycerol monoacrylates and monomethacrylates; (ii) a cross-linking agent selected from the group consisting of lower alkylene glycol diacrylates and dimethacrylates, allyl methacrylate, glycerol dimethacrylate, butantetrol dimethacrylate and N,N'-methylene-bisacrylamide; and (iii) an operative monomer selected from the group consisting of acrylic and methacrylic compounds containing a phenolic or aromatic amine function; and (b) a secondary component comprising a water-soluble polymer of a hydrophilic monoolefinic monomer selected from the group consisting of acrylic acid, methacrylic acid, itaconic acid, N-lower alkyl substituted acrylamides, lower alkylene glycol monomethacrylates and acrylates, acrylamide and methacrylamide, said water-soluble polymer containing an aromatic diazonium group, for a time sufficient to cause said diazonium group to form covalent bends with said primary component.
Claim 2
Independent Claim
165 words
A method for the production of carriers for binding biologically active compounds comprising admixing (a) a primary component comprising a three-dimensional water insoluble polymer of components: (i) at least one monomer selected from the group consisting of lower alkyl acrylates and methacrylates, lower hydroxyalkyl acrylates and methacrylates and diethylene glycol and glycerol monoacrylates and monomethacrylates; (ii) a cross-linking agent selected from the group consisting of lower alkylene glycol diacrylates and dimethacrylates, allyl methacrylate, glycerol dimethacrylate, butantetrol dimethacrylate and N,N'-methylene-bisacrylamide; and (iii) an operative monomer selected from the group consisting of acrylic and methacrylic compounds containing a phenolic or aromatic amine function; and (b) a secondary component comprising a water-soluble polymer of a hydrophilic monoolefinic monomer selected from the group consisting of acrylic acid, methacrylic acid, itaconic acid, N-lower alkyl substituted acrylamides, lower alkylene glycol monomethacrylates and acrylates, acrylamide and methacrylamide, said water-soluble polymer containing an aromatic diazonium group, for a time sufficient to cause said diazonium group to form covalent bends with said primary component.
Claim 3
Dependent Claim
13 words
The method of claim 1, wherein said monomer (a) (i) is 2-hydroxyethyl methacrylate.
Claim 4
Dependent Claim
13 words
The method of claim 1, wherein said cross-linking agent is ethylene glycol dimethacrylate.
Claim 5
Dependent Claim
11 words
The method of claim 1, wherein said operative monomer is methacryloylanilide.
Claim 6
Dependent Claim
11 words
The method of claim 1, wherein said operative monomer is 4-amino-acryloylanilide.
Claim 7
Dependent Claim
12 words
The method of claim 1, wherein said operative monomer is p-aminophenoxyethyl methacrylate.
Claim 8
Dependent Claim
19 words
The method of claim 1, wherein said secondary component is formed from diethylene glycol monomethacrylate and 2-(p-acetaminophenoxy) ethyl methacrylate.
Claim 9
Dependent Claim
15 words
A carrier for biologically active materials produced by the method as defined in claim 1.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-05-01 | 1981-10-31 | 1982-05-02 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-05-01 | 1985-10-31 | 1986-05-02 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-05-01 | 1989-10-31 | 1990-05-02 | $7700.00 | Window Closed / Lapsed |