US4086257A
Expired / Lapsed
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Phosphatidyl quaternary ammonium compounds
Assignee: LIPID SPECIALTIES Inc A CORP OF
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Filing: 1976-10-12
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Granted: 1978-04-25
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Expires: 1996-10-12
Abstract
Abstract Novel synthetic phosphatidyl ammonium hydroxide compounds are prepared which have a hydrophobic/hydrophilic balance different from the natural phosphatidylcholine, which alterations are carried out by changes in the quaternary ammonium polar group to provide different surfactant properties.
Inventors
- 👤 Barry D. Sears
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 20:31
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/66; A61K31/683; A61K31/685; A61K47/00; A61K47/06; A61K47/24; B; B82; B82Y; B82Y5/00; C; C07; C07F; C07F9/00; C07F9/02; C07F9/06; C07F9/08; C07F9/09; C07F9/10; C07F9/28; C07F9/54; C07F9/5407; Y; Y10; Y10T; Y10T428/00; Y10T428/29; Y10T428/2982; Y10T428/2984
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
74 words
A synthetic phosphatidyl quaternary ammonium compound represented by the formula: ##STR4## wherein R is a C 14 to C 20 hydrocarbon radical; a, b and c represent whole integers of from 0 to 3; d represents whole integers of from 1 to 5, except that in combination a, b and c cannot be zero and d cannot be two; and R 1 , R 2 , R 3 and R 4 are methylene radicals.
Claim 2
Dependent Claim
74 words
A synthetic phosphatidyl quaternary ammonium compound represented by the formula: ##STR4## wherein R is a C 14 to C 20 hydrocarbon radical; a, b and c represent whole integers of from 0 to 3; d represents whole integers of from 1 to 5, except that in combination a, b and c cannot be zero and d cannot be two; and R 1 , R 2 , R 3 and R 4 are methylene radicals.
Claim 3
Dependent Claim
13 words
The compound of claim 1 wherein R is an ethylenically unsaturated hydrocarbon radical.
Claim 4
Dependent Claim
11 words
The compound of claim 1 wherein R is a fatty radical.
Claim 5
Dependent Claim
13 words
The compound of claim 1 wherein the R radicals are different hydrocarbon radicals.
Claim 6
Dependent Claim
12 words
The compound of claim 1 wherein a, b and c are zero.
Claim 7
Dependent Claim
19 words
The compound of claim 1 wherein R 4 is a tetramethylene radical and a, b and c are zero.
Claim 8
Dependent Claim
32 words
The compound of claim 1 wherein R 4 is a trimethylene radical and a, b and c are one, and R 1 , R 2 and R 3 are a methylene radical.
Claim 9
Dependent Claim
11 words
The compound of claim 6 wherein R is a fatty radical.
Claim 10
Dependent Claim
19 words
The compound of claim 1 wherein ##STR5## is a myristoyl, palmitoyl, oleoyl, linoleoyl, stearoyl, egg yolk or soybean radical.
Claim 11
Dependent Claim
30 words
The compound of claim 1 selected from the group consisting of: dioleoyl phosphatidyl-(methylethylene-N-triethyl)ammonium; dipalmitoyl phosphatidyl-(ethylene-N-dimethylethyl)ammonium; distearoyl phosphatidyl-(ethylene-N-dimethylethyl)ammonium; oleoyl-palmitoyl phosphatidyl-(ethylene-N-dimethylethyl)ammonium; dimyristoyl phosphatidyl-(tetramethylene-N-dipropylmethyl)ammonium; dipalmitoyl phosphatidyl-(trimethylene-N-trimethyl)ammonium; egg phosphatidyl-(trimethylene-N-trimethyl)ammonium; soybean phosphatidyl-(trimethylene-N-trimethyl)ammonium; and dipalmitoyl phosphatidyl-(tetramethylene-N-trimethylene)ammonium.
Claim 12
Dependent Claim
19 words
The compound of claim 6 wherein ##STR6## is a myristoyl, palmitoyl, oleoyl, linoleoyl, stearoyl, egg yolk or soybean radical.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-04-24 | 1981-10-24 | 1982-04-25 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-04-24 | 1985-10-24 | 1986-04-25 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-04-24 | 1989-10-24 | 1990-04-25 | $7700.00 | Window Closed / Lapsed |