US4085207A
Expired / Lapsed
US
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Amino acid parenteral solution containing reducing sugar
Assignee: Otsuka Pharmaceutical Factory Inc
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Filing: 1976-03-24
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Granted: 1978-04-18
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Expires: 1996-03-24
Abstract
Abstract An amino acid parenteral solution containing at least one of N-acyl-L-tryptophans and N-acyl-L-prolines, and at least one reducing sugar.
Inventors
- 👤 Mitsuo Aoki
- 👤 Kazuhiko Watanabe
- 👤 Shunichi Murase
- 👤 Isao Hiraoka
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 12:05
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/33; A61K31/395; A61K31/41; A61K31/415; A61K31/40; A61K31/403; A61K31/404; A61K31/405; A61K31/70
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
112 words
A heat sterilized amino acid parenteral solution containing from about 0.06 to about 0.4 W/V% of a mixture of (i) at least one N-acyl-L-tryptophan and at least one N-acyl-L-proline, and (ii) from about 3 to about 25 W/V% of at least one reducing sugar, said N-acyl-L-tryptophan being at least one species selected from the group consisting of N-acetyl-L-tryptophan, N-lactyl-L-tryptophan, N-phenylacetyl-L-tryptophan, N-phenoxyacetyl-L-tryptophan, N-carbobenzoxy-L-tryptophan, N-oleyl-L-tryptophan, N-maleyl-L-tryptophan, N-benzoyl-L-tryptophan, N-glycyl-L-tryptophan and N-leucyl-L-tryptophan, said N-acyl-L-proline being at least one species selected from the group consisting of N-acetyl-L-proline, N-lactyl-L-proline, N-phenylacetyl-L-proline, N-phenoxyacetyl-L-proline, N-benzoyl-L-proline, N-carbobenzoxy-L-proline, N-valyl-L-proline, N-maleyl-L-proline, N-oleyl-L-proline, N-glycyl-L-proline and N-leucyl-L-proline, said reducing sugar being at least one species selected from the group consisting of glucose, fructose, maltose and lactose.
Claim 2
Dependent Claim
112 words
A heat sterilized amino acid parenteral solution containing from about 0.06 to about 0.4 W/V% of a mixture of (i) at least one N-acyl-L-tryptophan and at least one N-acyl-L-proline, and (ii) from about 3 to about 25 W/V% of at least one reducing sugar, said N-acyl-L-tryptophan being at least one species selected from the group consisting of N-acetyl-L-tryptophan, N-lactyl-L-tryptophan, N-phenylacetyl-L-tryptophan, N-phenoxyacetyl-L-tryptophan, N-carbobenzoxy-L-tryptophan, N-oleyl-L-tryptophan, N-maleyl-L-tryptophan, N-benzoyl-L-tryptophan, N-glycyl-L-tryptophan and N-leucyl-L-tryptophan, said N-acyl-L-proline being at least one species selected from the group consisting of N-acetyl-L-proline, N-lactyl-L-proline, N-phenylacetyl-L-proline, N-phenoxyacetyl-L-proline, N-benzoyl-L-proline, N-carbobenzoxy-L-proline, N-valyl-L-proline, N-maleyl-L-proline, N-oleyl-L-proline, N-glycyl-L-proline and N-leucyl-L-proline, said reducing sugar being at least one species selected from the group consisting of glucose, fructose, maltose and lactose.
Claim 3
Dependent Claim
30 words
The amino acid parenteral solution according to claim 1, in which said N-acyl-L-tryptophan is at least one species selected from the group consisting of N-acetyl-tryptophan, N-lactyl-L-tryptophan, N-phenylacetyl-L-tryptophan, N-carbobenzoxy-L-tryptophan and N-leucyl-L-tryptophan.
Claim 4
Dependent Claim
23 words
The amino acid parenteral solution according to claim 1, in which the concentration of said mixture of (i) is 0.07 to 0.3 W/V%.
Claim 5
Dependent Claim
25 words
The amino acid parenteral solution according to claim 1, in which the concentration of the reducing sugar (ii) is about 5 to about 20 W/V%.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-04-17 | 1981-10-17 | 1982-04-18 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-04-17 | 1985-10-17 | 1986-04-18 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-04-17 | 1989-10-17 | 1990-04-18 | $7700.00 | Window Closed / Lapsed |