US4085132A
Expired / Lapsed
US
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Process for the production of hydroxyalkylphenyl derivatives
Assignee: Novartis Corp
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Filing: 1975-06-24
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Granted: 1978-04-18
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Expires: 1995-06-24
Abstract
Abstract An improved process for the production of hydroxyalkylphenyl derivatives, especially esters containing hydroxyalkylphenyl groups is disclosed, which process comprises gradually adding methyl acrylate, in the presence of an alkaline catalyst, to the alkyl substituted phenolic compound and a suitable alcohol. The improved process results in good yields and in a reduction of undesirable by-products while avoiding isolation of the intermediates.
Inventors
- 👤 Kyong P. Park
- 👤 Anthony F. Vellturo
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-02 08:38
CPC Classifications
C; C07; C07C; C07C323/00
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
104 words
In the process for the production of a compound having the formula ##STR10## wherein R 1 and R 2 independently of each other represent an alkyl group having from 1 to 6 carbon atoms and x has a value from 6 to 30, inclusively, which comprises reacting methyl acrylate with a phenol of the formula ##STR11## and thereafter with a monohydric alcohol of the formula HO--(C.sub.x H.sub.2x)-- H Ia, in the presence of an alkaline catalyst, the improvement which consists essentially of a. gradually adding methyl acrylate to the reaction mixture which comprises said phenol, monohydric alcohol and a catalyst, without isolating the intermediate.
Claim 2
Dependent Claim
104 words
In the process for the production of a compound having the formula ##STR10## wherein R 1 and R 2 independently of each other represent an alkyl group having from 1 to 6 carbon atoms and x has a value from 6 to 30, inclusively, which comprises reacting methyl acrylate with a phenol of the formula ##STR11## and thereafter with a monohydric alcohol of the formula HO--(C.sub.x H.sub.2x)-- H Ia, in the presence of an alkaline catalyst, the improvement which consists essentially of a. gradually adding methyl acrylate to the reaction mixture which comprises said phenol, monohydric alcohol and a catalyst, without isolating the intermediate.
Claim 3
Dependent Claim
27 words
A process of claim 1 wherein R 2 is in the ortho position to the hydroxyl group and each R 1 and R 2 are branched alkyl.
Claim 4
Dependent Claim
22 words
A process of claim 2 wherein R 1 and R 2 are tert-butyl and x has a value of 12 to 24.
Claim 5
Dependent Claim
23 words
A process as claimed in claim 1, for the production of n-octadecyl-β-(3,5-di-t-butyl-4-hydroxyphenyl)propionate, which comprises gradually adding methyl acrylate to 2,6-di-t-butylphenol and n-octadecyl alcohol.
References Cited (Backward Citations)
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US2916532A
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US2927085A
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US2927086A
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FR1337163A
Cited
US3642868A
Cited
GB1001098A
Cited
USRE27004E
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-04-17 | 1981-10-17 | 1982-04-18 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-04-17 | 1985-10-17 | 1986-04-18 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-04-17 | 1989-10-17 | 1990-04-18 | $7700.00 | Window Closed / Lapsed |