US4083996A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Novel hydroxamic acid derivatives and medicaments for treatment of urolithiasis and pyelonephrosis comprising such derivatives
Assignee: Eisai Co Ltd
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Filing: 1977-02-17
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Granted: 1978-04-11
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Expires: 1997-02-17
Abstract
Abstract A novel compound having the general formula: ##STR1## wherein R 1 is a residual group selected from the group consisting of substituted phenyl, carbonoylaminophenyl and heterocyclic groups, and R 2 is hydrogen or methyl group, and its salts of a pharmacologically acceptable base and a novel medicament containing the compound or its salt mentioned above as a principal component; and the compound and the salt thereof having superior effect for the treatment of urolithiasis and the pyelonephrosis by exhibiting a strong urease inhibitory action, a high transfer rate into the urine and a low toxicity.
Inventors
- 👤 Satoru Tanaka
- 👤 Keiichi Munakata
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 04:16
CPC Classifications
C; C07; C07D; C07D213/00; C07D213/02; C07D213/04; C07D213/60; C07D213/78; C07D213/81; C07D213/82; C07D307/00; C07D307/02; C07D307/34; C07D307/56; C07D307/68; C07D317/00; C07D317/08; C07D317/44; C07D317/46; C07D317/48; C07D317/62; C07D317/68; C07D333/00; C07D333/02; C07D333/04; C07D333/26; C07D333/38
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
68 words
A compound having the general formula: ##STR51## wherein R 1 is a substituted phenyl group represented by a formula: ##STR52## wherein R 3 , R 4 and R 5 are selected from the group consisting of hydrogen and a lower alkoxy group, provided that at least one of them is a lower alkoxy group, R 2 is hydrogen or methyl group, and its salt of pharmacologically acceptable base.
Claim 2
Dependent Claim
68 words
A compound having the general formula: ##STR51## wherein R 1 is a substituted phenyl group represented by a formula: ##STR52## wherein R 3 , R 4 and R 5 are selected from the group consisting of hydrogen and a lower alkoxy group, provided that at least one of them is a lower alkoxy group, R 2 is hydrogen or methyl group, and its salt of pharmacologically acceptable base.
Claim 3
Dependent Claim
15 words
The compound according to claim 1, wherein the compound is represented by the formula: ##STR53##
Claim 4
Dependent Claim
15 words
The compound according to claim 1, wherein the compound is represented by the formula: ##STR54##
Claim 5
Dependent Claim
74 words
A medicament for urolithiasis which comprises a compound having the general formula: ##STR55## wherein R 1 is a substituted phenyl group represented by a formula: ##STR56## wherein R 3 , R 4 and R 5 are selected from the group consisting of hydrogen and a lower alkoxy group, provided that at least one of them is a lower alkoxy group, R 2 is hydrogen or methyl group, and its salt of pharmacologically acceptable base.
Claim 6
Dependent Claim
74 words
A medicament for urolithiasis which comprises a compound having the general formula: ##STR55## wherein R 1 is a substituted phenyl group represented by a formula: ##STR56## wherein R 3 , R 4 and R 5 are selected from the group consisting of hydrogen and a lower alkoxy group, provided that at least one of them is a lower alkoxy group, R 2 is hydrogen or methyl group, and its salt of pharmacologically acceptable base.
Claim 7
Dependent Claim
30 words
The medicament for the treatment of urolithiasis according to claim 4, which comprises the compound of the formula: ##STR57## and a salt of the compound with a pharmacologically acceptable base.
Claim 8
Dependent Claim
30 words
The medicament for the treatment of urolithiasis according to claim 4, which comprises the compound of the formula: ##STR58## and a salt of the compound with a pharmacologically acceptable base.
Claim 9
Dependent Claim
75 words
A medicament for the pyelonephrosis which comprises a compound having the general formula: ##STR59## wherein R 1 is a substituted phenyl group represented by a formula: ##STR60## wherein R 3 , R 4 and R 5 are selected from the group consisting of hydrogen and a lower alkoxy group, provided that at least one of them is a lower alkoxy group, R 2 is hydrogen or methyl group, and its salt of pharmacologically acceptable base.
Claim 10
Dependent Claim
75 words
A medicament for the pyelonephrosis which comprises a compound having the general formula: ##STR59## wherein R 1 is a substituted phenyl group represented by a formula: ##STR60## wherein R 3 , R 4 and R 5 are selected from the group consisting of hydrogen and a lower alkoxy group, provided that at least one of them is a lower alkoxy group, R 2 is hydrogen or methyl group, and its salt of pharmacologically acceptable base.
References Cited (Backward Citations)
US3728380A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-04-10 | 1981-10-10 | 1982-04-11 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-04-10 | 1985-10-10 | 1986-04-11 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-04-10 | 1989-10-10 | 1990-04-11 | $7700.00 | Window Closed / Lapsed |