US4083993A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Compositions containing benzoylacetonitrile and method of use to treat inflammation
Assignee: Wyeth Holdings LLC
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Filing: 1977-06-17
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Granted: 1978-04-11
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Expires: 1997-06-17
Abstract
Abstract This disclosure describes compositions of matter useful as anti-inflammatory agents and as inhibitors of the progressive joint deterioration characteristic of arthritic disease, and the method of meliorating inflammation and of inhibiting joint deterioration in mammals therewith, the active ingredients of said compositions of matter being benzoylacetonitrile, o-fluorobenzoylacetonitrile, m-fluorobenzoylacetonitrile, p-fluorobenzoylacetonitrile, or mixtures thereof.
Inventors
- 👤 Adolph Edward Sloboda
- 👤 John William Hanifin
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 18:38
CPC Classifications
C; C07; C07C; C07C255/00; A; A61; A61K; A61K31/00; A61K31/275; C07D; C07D333/00; C07D333/02; C07D333/04; C07D333/06; C07D333/24
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
37 words
The method of inhibiting the progression of arthritis in a mammal which comprises administering to said mammal an effective amount of an active ingredient selected from the group consisting of benzoylacetonitrile, o-fluorobenzoylacetonitrile, m-fluorobenzoylacetonitrile, p-fluorobenzoylacetonitrile and mixtures thereof.
Claim 2
Independent Claim
37 words
The method of inhibiting the progression of arthritis in a mammal which comprises administering to said mammal an effective amount of an active ingredient selected from the group consisting of benzoylacetonitrile, o-fluorobenzoylacetonitrile, m-fluorobenzoylacetonitrile, p-fluorobenzoylacetonitrile and mixtures thereof.
Claim 3
Independent Claim
36 words
The method of inhibiting progressive joint deterioration in a mammal which comprises administering to said mammal an effective amount of an active ingredient selected from the group consisting of benzoylacetonitrile, o-fluorobenzoylacetonitrile, m-fluorobenzoylacetonitrile, p-fluorobenzoylacetonitrile and mixtures thereof.
Claim 4
Independent Claim
36 words
The method of inhibiting progressive joint deterioration in a mammal which comprises administering to said mammal an effective amount of an active ingredient selected from the group consisting of benzoylacetonitrile, o-fluorobenzoylacetonitrile, m-fluorobenzoylacetonitrile, p-fluorobenzoylacetonitrile and mixtures thereof.
Claim 5
Independent Claim
34 words
The method of meliorating inflammation in a mammal which comprises administering to said mammal an effective amount of an active ingredient selected from the group consisting of benzoylacetonitrile, o-fluorobenzoylacetonitrile, m-fluorobenzoylacetonitrile, p-fluorobenzoylacetonitrile and mixtures thereof.
Claim 6
Independent Claim
34 words
The method of meliorating inflammation in a mammal which comprises administering to said mammal an effective amount of an active ingredient selected from the group consisting of benzoylacetonitrile, o-fluorobenzoylacetonitrile, m-fluorobenzoylacetonitrile, p-fluorobenzoylacetonitrile and mixtures thereof.
Claim 7
Dependent Claim
57 words
An anti-arthritic composition in dosage unit form useful for meliorating the inflammation and/or the progressive joint deterioration characteristic of arthritic disease in mammals comprising from about one milligram to about 250 milligrams per kilogram of body weight per daily dosage of an active ingredient selected from the group consisting of benzoylacetonitrile, o-fluorobenzoylacetonitrile, m-fluorobenzoylacetonitrile, p-fluorobenzoylacetonitrile and mixtures thereof.
Claim 8
Dependent Claim
57 words
An anti-arthritic composition in dosage unit form useful for meliorating the inflammation and/or the progressive joint deterioration characteristic of arthritic disease in mammals comprising from about one milligram to about 250 milligrams per kilogram of body weight per daily dosage of an active ingredient selected from the group consisting of benzoylacetonitrile, o-fluorobenzoylacetonitrile, m-fluorobenzoylacetonitrile, p-fluorobenzoylacetonitrile and mixtures thereof.
Claim 9
Dependent Claim
13 words
The composition in accordance with claim 4 wherein the active ingredient is benzoylacetonitrile.
Claim 10
Dependent Claim
13 words
The composition in accordance with claim 4 wherein the active ingredient is o-fluorobenzoylacetonitrile.
Claim 11
Dependent Claim
13 words
The composition in accordance with claim 4 wherein the active ingredient is m-fluorobenzoylacetonitrile.
Claim 12
Dependent Claim
13 words
The composition in accordance with claim 4 wherein the active ingredient is p-fluorobenzoylacetonitrile.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-04-10 | 1981-10-10 | 1982-04-11 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-04-10 | 1985-10-10 | 1986-04-11 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-04-10 | 1989-10-10 | 1990-04-11 | $7700.00 | Window Closed / Lapsed |