US4083947A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Organ visualization
Assignee: GE Healthcare Ltd
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Filing: 1976-06-22
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Granted: 1978-04-11
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Expires: 1996-06-22
Abstract
Abstract Novel selenium derivatives of steroids have the formula I, <IMAGE> (I) where X is hydrogen or acyl, Y is hydrocarbon and n is 0 or 1, preferably 0. Such compounds, labelled with selenium-75 are of use for investigating body function, particularly for imaging the adrenal glands, and are claimed superior for the purpose to the 6 beta - and 19- iodine derivatives of cholesterol.
Inventors
- 👤 Reginald Monks
- 👤 Anthony Leonard Mark Riley
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-28 16:11
CPC Classifications
A; A61; A61K; A61K51/00; A61K51/02; A61K51/04; A61K51/0493; C; C07; C07J; C07J51/00; A61K2123/00
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
29 words
Selenium derivatives of steroids having the general formula ##STR8## where X is hydrogen or acyl, Y is hydrocarbon containing up to 30 carbon atoms n is 0 or 1.
Claim 2
Dependent Claim
29 words
Selenium derivatives of steroids having the general formula ##STR8## where X is hydrogen or acyl, Y is hydrocarbon containing up to 30 carbon atoms n is 0 or 1.
Claim 3
Dependent Claim
32 words
Selenium derivatives of steroids as claimed in claim 1 wherein: X is hydrogen, or C1 to C18 acyl Y is C1 to C18 alkyl, cyclohexyl, phenyl or benzyl, and n is 0.
Claim 4
Dependent Claim
28 words
Selenium derivatives of steroids as claimed in claim 1 wherein the selenium includes an artificially high proportion of selenium-75, rendering the compounds suitable for use as body-scanning agents.
Claim 5
Dependent Claim
54 words
A method of investigating body function of a mammal, which method comprises introducing into the live mammal a 75 Se derivative of a steroid as claimed in claim 3, allowing the labelled steroid to become absorbed and localised in the mammal, and then observing the radiation emitted by the labelled steroid in the mammal.
Claim 6
Dependent Claim
55 words
A method according to claim 4 of visualizing a part of a mammal, which method comprises introducing into the live mammal a selenium derivative of a steroid as claimed in claim 3, allowing the labelled steroid to concentrate in the desired part, and observing the radiation emitted by the labelled steroid in the said part.
Claim 7
Dependent Claim
20 words
A method as claimed in claim 5, wherein the part of the mammal to be visualized is the adrenal glands.
Claim 8
Dependent Claim
57 words
A method of investigating body function of a mammal, which method comprises introducing into the live mammal a 75 Se derivative of a steroid as claimed in claim 3, allowing the labelled steroid to become absorbed and localised in the mammal, and then observing the radiation emitted by the labelled steroid in the excreta of the mammal.
References Cited (Backward Citations)
US3784576A
Cited
US3952030A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-04-10 | 1981-10-10 | 1982-04-11 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-04-10 | 1985-10-10 | 1986-04-11 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-04-10 | 1989-10-10 | 1990-04-11 | $7700.00 | Window Closed / Lapsed |