US4082845A
Expired / Lapsed
US
⏱️ 0.0 years remaining
3-(1-Piperazinyl)-pyrido[2,3-b]pyrazines
Assignee: Merck and Co Inc
•
Filing: 1977-04-25
•
Granted: 1978-04-04
•
Expires: 1997-04-25
Abstract
Abstract 3-(1-Piperazinyl)-pyrido[2,3-b]pyrazines and pharmaceutically acceptable salts thereof have serotoninmimetic activity. They are prepared by treating 3-halo-pyrido[2,3-b]pyrazines with piperazine.
Inventors
- 👤 Walfred S. Saari
- 👤 William C. Lumma, Jr.
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 14:18
CPC Classifications
C; C07; C07D; C07D471/00; C07D471/02; C07D471/04; A; A61; A61P; A61P25/00; A61P25/04; A61P25/24; A61P25/26; A61P3/00; A61P3/04
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
47 words
A compound of structural formula: ##STR3## or a pharmaceutically acceptable salt thereof, wherein R is hydrogen, halo, trifluoromethyl, lower alkyl having from 1 to 3 carbon atoms, lower alkylthio having from 1 to 3 carbon atoms, lower alkoxy having from 1 to 3 carbon atoms or cyano.
Claim 2
Dependent Claim
47 words
A compound of structural formula: ##STR3## or a pharmaceutically acceptable salt thereof, wherein R is hydrogen, halo, trifluoromethyl, lower alkyl having from 1 to 3 carbon atoms, lower alkylthio having from 1 to 3 carbon atoms, lower alkoxy having from 1 to 3 carbon atoms or cyano.
Claim 3
Dependent Claim
18 words
The compound of claim 1 wherein R is the 6- or 7-position, or a pharmaceutically acceptable salt thereof.
Claim 4
Dependent Claim
14 words
The compound of claim 1 which is 3-(1-piperazinyl)-pyrido[2,3-b]pyrazine or a pharmaceutically acceptable salt thereof.
Claim 5
Independent Claim
70 words
A method of producing an anorectic effect in a patient in need of such treatment comprising the administration of an effective amount of a compound of structural formula: ##STR4## or a pharmaceutically acceptable salt thereof, wherein R is hydrogen, halo, trifluoromethyl, lower alkyl having from 1 to 3 carbon atoms, lower alkylthio having from 1 to 3 carbon atoms, lower alkoxy having from 1 to 3 carbon atoms or cyano.
Claim 6
Independent Claim
70 words
A method of producing an anorectic effect in a patient in need of such treatment comprising the administration of an effective amount of a compound of structural formula: ##STR4## or a pharmaceutically acceptable salt thereof, wherein R is hydrogen, halo, trifluoromethyl, lower alkyl having from 1 to 3 carbon atoms, lower alkylthio having from 1 to 3 carbon atoms, lower alkoxy having from 1 to 3 carbon atoms or cyano.
Claim 7
Dependent Claim
60 words
A pharmaceutical anorectic composition comprising a pharmaceutical carrier and an effective amount of a compound of structural formula: ##STR5## or a pharmaceutically acceptable salt thereof, wherein R is hydrogen, halo, trifluoromethyl, lower alkyl having from 1 to 3 carbon atoms, lower alkylthio having from 1 to 3 carbon atoms, lower alkoxy having from 1 to 3 carbon atoms or cyano.
Claim 8
Dependent Claim
60 words
A pharmaceutical anorectic composition comprising a pharmaceutical carrier and an effective amount of a compound of structural formula: ##STR5## or a pharmaceutically acceptable salt thereof, wherein R is hydrogen, halo, trifluoromethyl, lower alkyl having from 1 to 3 carbon atoms, lower alkylthio having from 1 to 3 carbon atoms, lower alkoxy having from 1 to 3 carbon atoms or cyano.
References Cited (Backward Citations)
GB1440722A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-04-03 | 1981-10-03 | 1982-04-04 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-04-03 | 1985-10-03 | 1986-04-04 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-04-03 | 1989-10-03 | 1990-04-04 | $7700.00 | Window Closed / Lapsed |