3-substituted aminocycloalkyl esters of penicillin antibiotics

Claim 1

A penicillin ester of formula (I) or a pharmaceutically acceptable acid addition salt thereof: ##STR12## wherein R 1 and R 2 are the same or different and each represents a C 1-6 alkyl group or R 1 and R 2 taken together represents an alkylene chain optionally interrupted with an oxygen or nitrogen atoms forming a 5- or 6-membered heterocyclic ring; Z represents an optionally substituted straight or branched saturated or unsaturated divalent hydrocarbon radical wherein the optional substituents are selected from the group consisting of C 1 -C 6 alkyl, C 1 -C 6 alkoxy and halogen; X represents hydrogen, amino, carboxy, alkoxycarbonyl, phenoxycarbonyl, alkylphenoxycarbonyl or indanyl; R represents phenyenoptionally substituted with hydroxy or halogne; naphthyl optionally substituted with C 1-6 alkoxy; phenoxy optionally substituted with C 1-6 alkoxy; 2- or 3-thienyl, pyridyl, tetrazolyl, or the group RCHX represents phenyl optionally substituted with C 1-6 alkoxy or isoxazolyl optionally substituted with halogen or C 1-6 alkyl.