US4080506A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Phenacyl-type esters of PGA1 and PGA2
Assignee: Pharmacia and Upjohn Co
•
Filing: 1974-08-14
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Granted: 1978-03-21
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Expires: 1994-08-14
Abstract
Abstract Phenacyl-type esters of PGA 1 and PGA 2 are disclosed, represented by the formula ##STR1## wherein R 1 is phenyl, p-bromophenyl, p-biphenylyl, p-nitrophenyl, p-benzamidophenyl, or 2-naphthyl; wherein R 2 is hydrogen or benzoyl; and wherein Y is --CH 2 CH 2 -- or cis--CH═CH--. The products are useful for the same pharmacological and medical purposes as the corresponding prostaglandins and analogs, and are also useful as a means of obtaining highly purified products.
Inventors
- 👤 Walter Morozowich
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 13:44
CPC Classifications
C; C07; C07C; C07C405/00
Claims Analysis
Total Claims: 22
Claim 1
Independent Claim
37 words
An optically active compound of the formula: ##STR9## wherein R 1 is phenyl, p-bromophenyl, p-biphenylyl, p-nitrophenyl, p-benzamidophenyl, or 2-naphthyl; wherein R 2 is hydrogen or benzoyl; and wherein Y is --CH 2 CH 2 -- or cis--CH═CH--.
Claim 2
Dependent Claim
37 words
An optically active compound of the formula: ##STR9## wherein R 1 is phenyl, p-bromophenyl, p-biphenylyl, p-nitrophenyl, p-benzamidophenyl, or 2-naphthyl; wherein R 2 is hydrogen or benzoyl; and wherein Y is --CH 2 CH 2 -- or cis--CH═CH--.
Claim 3
Dependent Claim
14 words
A compound according to claim 1 wherein Y is --CH 2 CH 2 --.
Claim 4
Dependent Claim
13 words
The phenacyl ester of PGA 1 , a compound according to claim 2.
Claim 5
Dependent Claim
13 words
The p-phenylphenacyl ester of PGA 1 , a compound according to claim 2.
Claim 6
Dependent Claim
13 words
The p-nitrophenacyl ester of PGA 1 , a compound according to claim 2.
Claim 7
Dependent Claim
13 words
The p-benzamidophenacyl ester of PGA 1 , a compound according to claim 2.
Claim 8
Dependent Claim
13 words
The 2-naphthoylmethyl ester of PGA 1 , a compound according to claim 2.
Claim 9
Dependent Claim
13 words
The α-benzoylphenacyl ester of PGA 1 , a compound according to claim 2.
Claim 10
Dependent Claim
11 words
A compound according to claim 1 wherein Y is a cis--CH═CH--.
Claim 11
Dependent Claim
13 words
The phenacyl ester of PGA 2 , a compound according to claim 9.
Claim 12
Dependent Claim
13 words
The p-phenylphenacyl ester of PGA 2 , a compound according to claim 9.
Claim 13
Dependent Claim
13 words
The p-nitrophenacyl ester of PGA 2 , a compound according to claim 9.
Claim 14
Dependent Claim
13 words
The p-benzamidophenacyl ester of PGA 2 , a compound according to claim 9.
Claim 15
Dependent Claim
13 words
The 2-naphthoylmethyl ester of PGA 2 , a compound according to claim 9.
Claim 16
Dependent Claim
13 words
The α-benzoylphenacyl ester of PGA 2 , a compound according to claim 9.
Claim 17
Dependent Claim
9 words
Free-flowing crystals of a compound of the formula: ##STR10##
Claim 18
Dependent Claim
9 words
Free-flowing crystals of a compound of the formula: ##STR10##
Claim 19
Dependent Claim
9 words
Free-flowing crystals of a compound of the formula: ##STR11##
Claim 20
Dependent Claim
9 words
Free-flowing crystals of a compound of the formula: ##STR11##
Claim 21
Dependent Claim
30 words
An optically active compound of the formula ##STR12## wherein R 1 is phenyl, p-bromophenyl, p-biphenylyl, p-nitrophenyl, p-benzamidophenyl, or 2-naphthyl; and wherein Y is --CH 2 CH 2 -- or cis--CH═CH--.
Claim 22
Dependent Claim
30 words
An optically active compound of the formula ##STR12## wherein R 1 is phenyl, p-bromophenyl, p-biphenylyl, p-nitrophenyl, p-benzamidophenyl, or 2-naphthyl; and wherein Y is --CH 2 CH 2 -- or cis--CH═CH--.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-03-20 | 1981-09-19 | 1982-03-21 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-03-20 | 1985-09-19 | 1986-03-21 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-03-20 | 1989-09-19 | 1990-03-21 | $7700.00 | Window Closed / Lapsed |