US4080324A
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Ethylenediamineplatinum(II) 2,4-dioxopyrimidine complexes
Assignee: Engelhard Minerals and Chemicals Corp
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Filing: 1976-01-21
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Granted: 1978-03-21
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Expires: 1996-01-21
Abstract
Abstract Ethylenediamineplatinum(II) 2,4-dioxopyrimidine complexes are characterized by high anti-tumor activity and low mammalian toxicity.
Inventors
- 👤 James D. Hoeschele
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 23:41
CPC Classifications
C; C07; C07H; C07H23/00; C07D; C07D239/00; C07D239/02; C07D239/24; C07D239/28; C07D239/46; C07D239/52; C07D239/54; C07F; C07F15/00; C07F15/0006; C07F15/0086; C07F15/0093
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
104 words
A non-blue ethylenediamineplatinum(II) 2,4-dioxopyrimidine complex formed by reacting in an aqueous medium at neutral pH or below a diaquoethylenediamineplatinum(II) salt having the formula: ##STR6## wherein each of R 3 -R 8 is hydrogen or lower alkyl, X is an anion, and n is a number having a value of 0 or 1; with a 2,4-dioxopyrimidine having the formula: ##STR7## wherein R is hydrogen or lower alkyl and each of R 1 and R 2 , independently is hydrogen, halogen, lower alkyl, carboxyl, lower alkoxycarbonyl, hydroxy, and lower alkoxy, and the dihydro derivatives of said 2,4-dioxopyrimidines, and thereafter recovering said complex from said reaction medium.
Claim 2
Dependent Claim
104 words
A non-blue ethylenediamineplatinum(II) 2,4-dioxopyrimidine complex formed by reacting in an aqueous medium at neutral pH or below a diaquoethylenediamineplatinum(II) salt having the formula: ##STR6## wherein each of R 3 -R 8 is hydrogen or lower alkyl, X is an anion, and n is a number having a value of 0 or 1; with a 2,4-dioxopyrimidine having the formula: ##STR7## wherein R is hydrogen or lower alkyl and each of R 1 and R 2 , independently is hydrogen, halogen, lower alkyl, carboxyl, lower alkoxycarbonyl, hydroxy, and lower alkoxy, and the dihydro derivatives of said 2,4-dioxopyrimidines, and thereafter recovering said complex from said reaction medium.
Claim 3
Dependent Claim
13 words
A complex according to claim 1 wherein R is hydrogen or lower alkyl.
Claim 4
Dependent Claim
13 words
A complex according to claim 2 wherein R 3 -R 8 is hydrogen.
Claim 5
Dependent Claim
17 words
A complex according to claim 3 wherein each of R, R 1 and R 2 is hydrogen.
Claim 6
Dependent Claim
18 words
A complex according to claim 3 wherein R and R 1 are hydrogen and R 2 is methyl.
Claim 7
Dependent Claim
18 words
A complex according to claim 3 wherein R and R 1 are hydrogen and R 2 is fluoro.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-03-20 | 1981-09-19 | 1982-03-21 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-03-20 | 1985-09-19 | 1986-03-21 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-03-20 | 1989-09-19 | 1990-03-21 | $7700.00 | Window Closed / Lapsed |