US4077997A
Expired / Lapsed
US
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Diphosphonoalkane carboxylic acids, process of preparation and methods of use
Assignee: Henkel AG and Co KGaA
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Filing: 1977-01-21
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Granted: 1978-03-07
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Expires: 1997-01-21
Abstract
Abstract Diphosphonoalkane carboxylic acids having the formula ##STR1## wherein R is H or --CH 2 --CH 2 --COOH; as well as their water-soluble salts. The compounds are excellent sequestering agents, especially for alkaline earth and earth metal ions. They are stabilizers for percompounds and are useful in the delaying of the setting times for gypsum. In addition, the compounds are useful in cosmetic preparations, such as toothpastes and mouthwashes where they prevent formation of tartar and plaque and are useful in therapy in the treatment of diseases related to the abnormal deposition or dissolution of difficultly soluble calcium salts in the animal body.
Inventors
- 👤 Helmut Blum
- 👤 Karl-Heinz Worms
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 04:22
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/66; A61K8/00; A61K8/18; A61K8/30; A61K8/55; A61P; A61P3/00; A61Q; A61Q11/00; C; C07; C07F; C07F9/00; C07F9/02; C07F9/28; C07F9/38; C07F9/3804; C07F9/3839; C11; C11D; C11D3/00; C11D3/16; C11D3/36; C11D3/365; Y; Y10; Y10S; Y10S71/00; Y10S71/02
Claims Analysis
Total Claims: 3
Claim 1
Independent Claim
25 words
A diphosphonoalkane carboxylic acid selected from the group consisting of (A) a compound of the formula ##STR7## and (B) a non-toxic, pharmacologically-acceptable water-soluble salt thereof.
Claim 2
Dependent Claim
25 words
A diphosphonoalkane carboxylic acid selected from the group consisting of (A) a compound of the formula ##STR7## and (B) a non-toxic, pharmacologically-acceptable water-soluble salt thereof.
Claim 3
Dependent Claim
63 words
A process for the production of the diphosphonoalkane carboxylic acid of claim 1, consisting essentially of reacting a lower alkyl ester of acrylic acid with a lower alkyl ester of methylene diphosphonic acid in at least a 2:1 molar ratio in the presence of a strongly basic catalyst, saponifying the reaction product under aqueous acidic saponification conditions and recovering said diphosphonoalkane carboxylic acid.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-03-06 | 1981-09-05 | 1982-03-07 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-03-06 | 1985-09-05 | 1986-03-07 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-03-06 | 1989-09-05 | 1990-03-07 | $7700.00 | Window Closed / Lapsed |