US4076913A
Expired / Lapsed
US
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Solid or gel polymers containing a plurality of free hydrazone groups
Assignee: Glaxo Laboratories Ltd
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Filing: 1976-09-27
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Granted: 1978-02-28
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Expires: 1996-09-27
Abstract
Abstract Novel polymers are provided which carry diazomethylene or hydrazonomethylene groups. Such polymers are of special use in immobilizing carboxylic acids, such as amino acids, with a view to subsequent chemical transformation of such acids, e.g. peptide synthesis. Alcohols and thiols may also be immobilized using the new polymers. Methods for the preparation of the polymers are provided, starting from a variety of polymer types.
Inventors
- 👤 Derek Walker
- 👤 Philip Howard Chapman
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 18:51
CPC Classifications
C; C08; C08G; C08G61/00; C08G61/02; C08F; C08F8/00; C08F8/06; C08F8/10; C08F8/18; C08F8/20; C08F8/26; C08F8/30; C08F8/32; C08G85/00; C08G85/004; C08F2810/00; C08F2810/20
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
76 words
A solid or gel polymer which is insoluble in dilute aqueous acid and possesses a plurality of hydrazone groups, > C═N--NH 2 , wherein each hydrazone group either forms part of the polymer backbone chain or forms part of a side-chain attached to the polymer backbone chain in which case one of the valencies of each hydrazone group is linked to the polymer backbone chain and the other valency is bonded to an organic substituting group.
Claim 2
Dependent Claim
76 words
A solid or gel polymer which is insoluble in dilute aqueous acid and possesses a plurality of hydrazone groups, > C═N--NH 2 , wherein each hydrazone group either forms part of the polymer backbone chain or forms part of a side-chain attached to the polymer backbone chain in which case one of the valencies of each hydrazone group is linked to the polymer backbone chain and the other valency is bonded to an organic substituting group.
Claim 3
Dependent Claim
12 words
A polymer as claimed in claim 1 which is a solid polymer.
Claim 4
Dependent Claim
75 words
A polymer as claimed in claim 1 wherein the organic substituting group is an alkyl group containing 1 to 20 carbon atoms; an aryl group; a 5- or 6-membered heterocyclic ring containing 1 or more heteroatoms selected from O, N and S; heterocyclic substituted alkyl groups; unsaturated analogues of the above groups; or any of the preceding groups substituted by 1 or more halogen atoms, cyano, nitro, sulphone, oxo, esterified carboxy, alkyl or alkoxy groups.
Claim 5
Dependent Claim
22 words
A polymer as claimed in claim 1 wherein the plurality of hydrazone groups are randomly distributed along the length of the polymer.
Claim 6
Dependent Claim
23 words
A polymer as claimed in claim 1 wherein the hydrazone groups are linked to the polymer backbone through an alkylene or arylene group.
Claim 7
Dependent Claim
17 words
A polymer as claimed in claim 1 in which the backbone chain contains units derived from styrene.
Claim 8
Dependent Claim
24 words
A polymer as claimed in claim 6 which had been cross-linked by the presence of from 0.1 to 8% by weight of divinyl benzene.
Claim 9
Dependent Claim
49 words
A polymer as claimed in claim 6 wherein one of the valencies of each hydrazone group is linked to the polymer backbone chain through a phenyl group and the other valency is linked to a phenyl group which may be substituted by one or more alkyl or alkoxy groups.
References Cited (Backward Citations)
GB497031A
Cited
GB793292A
Cited
GB839377A
Cited
GB864874A
Cited
GB1046464A
Cited
GB1337870A
Cited
GB1322698A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-02-27 | 1981-08-29 | 1982-02-28 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-02-27 | 1985-08-29 | 1986-02-28 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-02-27 | 1989-08-29 | 1990-02-28 | $7700.00 | Window Closed / Lapsed |