US4076829A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Aminopropanol compounds and compositions for the treatment of cardiac and circulatory diseases
Assignee: Roche Diagnostics GmbH
•
Filing: 1975-10-28
•
Granted: 1978-02-28
•
Expires: 1995-10-28
Abstract
Abstract New aminopropanol compounds of the formula (I) <IMAGE> wherein R is lower alkyl, cycloalkyl or alkylthioalkyl, R1 is hydrogen or lower alkyl, hydroxyalkyl, pivaloyloxyalkyl, alkoxyalkyl, alkoxycarbonyl, carboxyl or -CONR3R4, in which R3 and R4 which can be the same or different, represent hydrogen or lower alkyl, and R2 is lower alkyl, hydroxyalkyl, alkoxyalkyl or pivaloyloxyalkyl or, when R is alkylthioalkyl or R1 is pivaloyloxyalkyl, R2 can also be hydrogen and THE PHARMACOLOGICALLY ACCEPTABLE SALTS THEREOF; ARE OUTSTANDINGLY EFFECTIVE IN THE TREATMENT OR PROPHYLAXIS OF CARDIAC AND CIRCULATORY DISEASES.
Inventors
- 👤 Wolfgang Kampe
- 👤 Kurt Stach
- 👤 Max Thiel
- 👤 Wolfgang Bartsch
- 👤 Karl Dietmann
- 👤 Egon Roesch
- 👤 Wolfgang Schaumann
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 12:44
CPC Classifications
C; C07; C07D; C07D209/00; C07D209/02; C07D209/04; C07D209/30; C07D209/42; A; A61; A61P; A61P25/00; A61P25/02; C07D209/08; C07D209/10; C07D209/12
Claims Analysis
Total Claims: 21
Claim 1
Independent Claim
45 words
Aminopropanol compound of the formula ##STR8## wherein R is lower alkyl or cycloalkyl R 1 is hydrogen or lower alkyl, hydroxyalkyl, alkoxyalkyl, and R 2 is in the 6- position and is selected from lower alkyl, hydroxyalkyl, and alkoxyalkyl and the pharmacologically acceptable salts thereof.
Claim 2
Dependent Claim
45 words
Aminopropanol compound of the formula ##STR8## wherein R is lower alkyl or cycloalkyl R 1 is hydrogen or lower alkyl, hydroxyalkyl, alkoxyalkyl, and R 2 is in the 6- position and is selected from lower alkyl, hydroxyalkyl, and alkoxyalkyl and the pharmacologically acceptable salts thereof.
Claim 3
Dependent Claim
17 words
Aminopropanol compound as claimed in claim 1 wherein R is alkyl of up to 6 carbon atoms.
Claim 4
Dependent Claim
19 words
Aminopropanol compound as claimed in claim 1 wherein R is cycloalkyl of from 3 to 6 ring carbon atoms.
Claim 5
Dependent Claim
12 words
Aminopropanol compound as claimed in claim 1 wherein R 1 is hydrogen.
Claim 6
Dependent Claim
18 words
Aminopropanol compound as claimed in claim 1 wherein R 1 is alkyl of up to 6 carbon atoms.
Claim 7
Dependent Claim
18 words
Aminopropanol compound as claimed in claim 1 wherein R 1 is hydroxyalkyl of up to 6 carbon atoms.
Claim 8
Dependent Claim
22 words
Aminopropanol compound as claimed in claim 1 wherein R 1 is alkoxyalkyl of up to 6 carbon atoms in each alkyl moiety.
Claim 9
Dependent Claim
18 words
Aminopropanol compound as claimed in claim 1 wherein R 2 is alkyl of up to 6 carbon atoms.
Claim 10
Dependent Claim
18 words
Aminopropanol compound as claimed in claim 1 wherein R 2 is hydroxyalkyl of up to 6 carbon atoms.
Claim 11
Dependent Claim
22 words
Aminopropanol compound as claimed in claim 1 wherein R 2 is alkoxyalkyl of up to 6 carbon atoms in each alkyl moiety.
Claim 12
Dependent Claim
9 words
Aminopropanol compound as claimed in claim 1 designated 4-(2-hydroxy-3-tert.-butylamino-propoxy)-6-hydroxymethyl-indole.
Claim 13
Dependent Claim
9 words
Aminopropanol compound as claimed in claim 1 designated 4-(2-hydroxy-3-tert.-butylamino-propoxy)-6-methyl-indole
Claim 14
Dependent Claim
9 words
Aminopropanol compound as claimed in claim 1 designated 4-(2-hydroxy-3-isopropylamino-propoxy)-6-methyl-indole.
Claim 15
Dependent Claim
40 words
Therapeutic composition for the treatment or prophylaxis of cardiac and circulatory diseases which composition comprises a pharmaceutically acceptable carrier and in amounts effective for treatment or prophylaxis of cardiac or circulatory diseases an aminopropanol compound as claimed in claim 1.
Claim 16
Dependent Claim
74 words
Method of combatting or preventing cardiac and circulatory infirmities which method comprises administering to a mammal in amounts effective for treatment or prophylaxis of cardiac or circulatory diseases an aminopropanol compound of the formula ##STR9## wherein R is lower alkyl or cycloalkyl R 1 is hydrogen or lower alkyl, hydroxyalkyl, alkoxyalkyl, and R 2 is in the 6- position and is selected from lower alkyl, hydroxyalkyl, and alkoxyalkyl and the pharmacologically acceptable salts thereof.
Claim 17
Dependent Claim
74 words
Method of combatting or preventing cardiac and circulatory infirmities which method comprises administering to a mammal in amounts effective for treatment or prophylaxis of cardiac or circulatory diseases an aminopropanol compound of the formula ##STR9## wherein R is lower alkyl or cycloalkyl R 1 is hydrogen or lower alkyl, hydroxyalkyl, alkoxyalkyl, and R 2 is in the 6- position and is selected from lower alkyl, hydroxyalkyl, and alkoxyalkyl and the pharmacologically acceptable salts thereof.
Claim 18
Dependent Claim
16 words
Method as claimed in claim 15 wherein said compound is selected from 4-(2-hydroxy-3-tert.-butylamino-propoxy)-6-hydroxymethyl-indole, 4-(2-hydroxy-3-tert.-butylamino-propoxy)-6-methyl-indole, and 4-(2-hydroxy-3-isopropylamino-propoxy)-6-methyl-indole.
Claim 19
Dependent Claim
25 words
Method as claimed in claim 15 wherein said compound is applied at a dosage of 1 to 40 mg up to four times a day.
Claim 20
Dependent Claim
19 words
Method as claimed in claim 15 wherein said compound is applied orally in dosages of 20 to 40 mg.
Claim 21
Dependent Claim
23 words
Method as claimed in claim 15 wherein said compound is applied intravenously at a dosage of from 1 to 5 mg per dosage.
References Cited (Backward Citations)
US3471515A
Cited
US3479371A
Cited
US3696121A
Cited
US3696120A
Cited
US3705907A
Cited
US3751429A
Cited
US3758502A
Cited
US3808231A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-02-27 | 1981-08-29 | 1982-02-28 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-02-27 | 1985-08-29 | 1986-02-28 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-02-27 | 1989-08-29 | 1990-02-28 | $7700.00 | Window Closed / Lapsed |