US4073922A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Treatment of rheumatoid arthritis and related diseases
Assignee: Individual
•
Filing: 1976-06-29
•
Granted: 1978-02-14
•
Expires: 1996-06-29
Abstract
Abstract It is believed that rheumatoid arthritis and related collagen and auto-immune diseases are an infection and that various species of free-living (limax) amoebae are the aetiological agent of these diseases. It has been discovered that clotrimazole bis-phenyl (2-chlorphenyl)-1-imidazolyl-methane! and related compounds, antimycotic drugs with anti-protozoal activity, are effective for the treatment of rheumatoid arthritis and other collagen and auto-immune (rheumatoid) diseases.
Inventors
- 👤 Roger Wyburn-Mason
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 12:10
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/33; A61K31/395; A61K31/41; A61K31/415; A61P; A61P29/00; A61P33/00; A61P33/02
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
37 words
A method for producing remission in patients suffering from active rheumatoid arthritis which comprises administering to such a patient a bis-phenyl (2-halophenyl)-1-imidazolyl-methane wherein the halo substituent is selected from the group consisting of chlorine, bromine and iodine.
Claim 2
Independent Claim
37 words
A method for producing remission in patients suffering from active rheumatoid arthritis which comprises administering to such a patient a bis-phenyl (2-halophenyl)-1-imidazolyl-methane wherein the halo substituent is selected from the group consisting of chlorine, bromine and iodine.
Claim 3
Dependent Claim
20 words
The method of claim 1 wherein the daily dose amount is from about 1.5 to about 2.5 grams per day.
Claim 4
Dependent Claim
11 words
The method of claim 1, wherein the bis-phenyl (2-halophenyl)-1-imidazolyl-methane is clotrimazole.
Claim 5
Dependent Claim
28 words
The method of claim 1, wherein the bis-phenyl (2-halophenyl-1-imidazolyl-methane is clotrimazole and is administered orally in doses of approximately 100 mg. per kilogram of body weight per day.
Claim 6
Dependent Claim
35 words
The method of combating rheumatoid arthritis of claim 3, which comprises orally administering to the infected subject clotrimazole in a total daily dose amount of about 10 to 100 miligrams per kilogram of body weight.
References Cited (Backward Citations)
US3657445A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-02-13 | 1981-08-15 | 1982-02-14 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-02-13 | 1985-08-15 | 1986-02-14 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-02-13 | 1989-08-15 | 1990-02-14 | $7700.00 | Window Closed / Lapsed |