US4072710A
Expired / Lapsed
US
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Process for preparing acid chlorides
Assignee: Individual
•
Filing: 1975-11-07
•
Granted: 1978-02-07
•
Expires: 1995-11-07
Abstract
Abstract A process for preparing acid chlorides, wherein a silyl ester having an aliphatic, aromatic, alkanoaromatic or heterocyclic group which may support substituents, and having a low molecular weight alkyl or phenyl group is reacted with thionyl chloride in an inert solvent at a temperature of from -15° to 50° C, preferably from 10° to 50° C.
Inventors
- 👤 Antonio Luis Palomo Coll
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-31 21:29
CPC Classifications
C; C07; C07D; C07D213/00; C07D213/02; C07D213/04; C07D213/60; C07D213/78; C07C; C07C201/00; C07C201/06; C07C201/12; C07C205/00; C07C205/49; C07C205/50; C07C205/51; C07C205/52; C07C205/53; C07C205/57; C07C227/00; C07C227/14; C07C227/18; C07C231/00; C07C231/12; C07C247/00; C07C247/02; C07C247/12; C07C251/00; C07C251/02; C07C251/04; C07C251/10; C07C251/16; C07C253/00; C07C253/30; C07C281/00; C07C291/00; C07C291/02; C07C291/04; C07C303/00; C07C303/02; C07C303/22; C07C405/00; C07C51/00; C07C51/58; C07C51/60; C07D215/00; C07D215/02; C07D215/16; C07D215/48; C07D243/00; C07D243/06; C07D243/10; C07D243/12; C07D243/14; C07D243/16; C07D243/18; C07D243/24; C07D261/00; C07D261/02; C07D261/06; C07D261/10; C07D261/18; C07D263/00; C07D263/02; C07D263/30; C07D263/34; C07D263/36; C07D263/42; C07D281/00; C07D281/02; C07D281/04; C07D281/08; C07D281/10; C07D295/00; C07D295/16; C07D295/18; C07D295/182; C07D295/185; C07D307/00; C07D307/02; C07D307/34; C07D307/38; C07D307/54; C07D307/56; C07D307/68; C07D311/00; C07D311/02; C07D311/04; C07D311/22; C07D311/24; C07D333/00; C07D333/02; C07D333/04; C07D333/06; C07D333/24; C07D333/26; C07D333/38; C07D499/00; C07C2602/00; C07C2602/02; C07C2602/04; C07C2602/08
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
97 words
A process for the preparation of acid chlorides, wherein there is used a silyl ester of the following general formula: ##STR2## where R is a substituted or unsubstituted aralkyl, aliphatic, aromatic, or heterocyclic group provided that the substituent is not an amino group, and R 1 , R 2 and R 3 are alkyl of 1-3 carbon atoms or phenyl, which is reacted with thionyl chloride in an inert solvent at a temperature of from -15° to 50° C to obtain a compound of the general formula: R--COCl where R has the same meaning as given above.
Claim 2
Dependent Claim
97 words
A process for the preparation of acid chlorides, wherein there is used a silyl ester of the following general formula: ##STR2## where R is a substituted or unsubstituted aralkyl, aliphatic, aromatic, or heterocyclic group provided that the substituent is not an amino group, and R 1 , R 2 and R 3 are alkyl of 1-3 carbon atoms or phenyl, which is reacted with thionyl chloride in an inert solvent at a temperature of from -15° to 50° C to obtain a compound of the general formula: R--COCl where R has the same meaning as given above.
Claim 3
Dependent Claim
30 words
A process for the preparation of acid chlorides, wherein an acid trimethylsilyl ester is reacted in a solvent with thionyl chloride at a temperature of between 10° and 50° C.
Claim 4
Dependent Claim
30 words
A process for the preparation of acid chlorides, wherein an acid trimethylsilyl ester is reacted in a solvent with thionyl chloride at a temperature of between 10° and 50° C.
Claim 5
Dependent Claim
50 words
A process of claim 1, wherein the reaction between a silyl ester and thionyl chloride is conducted in an inert medium selected from the group of solvents consisting of methylene chloride, acetonitrile, chloroform, 1,2-dichloroethane, 1,2-dimethoxyethane, benzene, toluene, xylene, chlorobenzene, tetrahydrofurane, dioxane, chloroform, dichloroethylene, carbon tetrachloride, to obtain an acid chloride.
Claim 6
Dependent Claim
35 words
The process of claim 2, wherein the trimethylsilyl ester is obtained in a solvent by reaction of an acid with a silylating agent, and is thereafter reacted with thionyl chloride to obtain an acid chloride.
Claim 7
Dependent Claim
96 words
The process of claim 1, wherein an acid is reacted with a silylating reactant of the group consisting of trimethylchlorosilane, hexamethyldisilazane, bis-trimethylsilylacetamide, bis-silylurea, 3-tripropylsilylchlorosilane, butyldiethylchlorosilane, triphenylchlorosilane, silylphosphorimidates and bis-silylformamide, to obtain a compound of the following formula: ##STR3## where R, R 1 R 2 and R 3 have the meaning given above, R being capable of supporting the substituents methyl, methoxy, nitro, cyano, carboxy, carboxyesters, carbamoyl, halogen, hydroxyl, thiol, sulphonic and sulphonamido, which is reacted with thionyl chloride to obtain a compound of the general formula: RCOCl where R has the same meaning as given above.
Claim 8
Dependent Claim
24 words
A process for preparing α-chlorophenylacetyl chloride which comprises reacting α-chlorophenylacetic acid silyl ester with thionyl chloride in an inert solvent at about 20° C.
Claim 9
Dependent Claim
24 words
A process for preparing α-chlorophenylacetyl chloride which comprises reacting α-chlorophenylacetic acid silyl ester with thionyl chloride in an inert solvent at about 20° C.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-02-06 | 1981-08-08 | 1982-02-07 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-02-06 | 1985-08-08 | 1986-02-07 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-02-06 | 1989-08-08 | 1990-02-07 | $7700.00 | Window Closed / Lapsed |