US4072683A
Expired / Lapsed
US
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3,4-Dihydrocarbostyril derivatives
Assignee: Otsuka Pharmaceutical Co Ltd
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Filing: 1975-11-10
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Granted: 1978-02-07
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Expires: 1995-11-10
Abstract
Abstract Novel (3'-alkylamino-2'-hydroxy)propoxy-3,4-dihydrocarbostyril derivatives having beta -adrenergic nerves blocking activity and hypotensive activity and useful as a remedy for angina pectoris, irregular pulse and hypertension, etc., represented by the formula, <IMAGE> wherein R1 is hydrogen, C1-C4 alkyl or aralkyl and R2 is C1-C4 alkyl, are prepared by reacting a 3,4-dihydrocarbostyril derivative represented by the formula, <IMAGE> wherein R1 is C1-C4 alkyl or aralkyl, with an epihalogenohydrin represented by the formula, <IMAGE> wherein X is halogen, reacting the resulting product with an alkylamine represented by the formula, R2 - NH2 wherein R2 is as defined above, and, if necessary, reducing the resulting product.
Inventors
- 👤 Kazuyuki Nakagawa
- 👤 Minoru Uchida
- 👤 Hiroaki Oka
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 22:51
CPC Classifications
C; C07; C07D; C07D215/00; C07D215/02; C07D215/16; C07D215/20; C07D215/24; C07D215/26
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
36 words
A compound of the formula, ##STR21## wherein R 1 is hydrogen, C 1 -C 4 alkyl, benzyl or phenethyl and R 2 is C 1 -C 4 alkyl or a pharmaceutically acceptable acid addition salt thereof.
Claim 2
Dependent Claim
36 words
A compound of the formula, ##STR21## wherein R 1 is hydrogen, C 1 -C 4 alkyl, benzyl or phenethyl and R 2 is C 1 -C 4 alkyl or a pharmaceutically acceptable acid addition salt thereof.
Claim 3
Dependent Claim
9 words
5-(3'-tert-Butylamino-2'-hydroxy)propoxy-8-hydroxy-3,4-dihydrocarbostyril or a pharmaceutically acceptable acid addition salt thereof.
Claim 4
Dependent Claim
9 words
5-(3'-tert-Butylamino-2'-hydroxy)propoxy-8-hydroxy-3,4-dihydrocarbostyril or a pharmaceutically acceptable acid addition salt thereof.
Claim 5
Dependent Claim
9 words
5-(3'-Isopropylamino-2'-hydroxy)propoxy-8-hydroxy-3,4-dihydrocarbostyril or a pharmaceutically acceptable acid addition salt thereof.
Claim 6
Dependent Claim
9 words
5-(3'-Isopropylamino-2'-hydroxy)propoxy-8-hydroxy-3,4-dihydrocarbostyril or a pharmaceutically acceptable acid addition salt thereof.
Claim 7
Dependent Claim
7 words
5-(3'-sec-Butylamino-2'-hydroxy)propoxy-8-hydroxy-3,4-dihydrocarbostyril or a pharmaceutically acceptable salt thereof.
Claim 8
Dependent Claim
7 words
5-(3'-sec-Butylamino-2'-hydroxy)propoxy-8-hydroxy-3,4-dihydrocarbostyril or a pharmaceutically acceptable salt thereof.
Claim 9
Dependent Claim
9 words
5-(3'-tert-Butylamino-2'-hydroxy)propoxy-8-methoxy-3,4-dihydrocarbostyril or a pharmaceutically acceptable acid addition salt thereof.
Claim 10
Dependent Claim
9 words
5-(3'-tert-Butylamino-2'-hydroxy)propoxy-8-methoxy-3,4-dihydrocarbostyril or a pharmaceutically acceptable acid addition salt thereof.
Claim 11
Dependent Claim
9 words
5-(3'-tert-Butylamino-2'-hydroxy)propoxy-8-benzyloxy-3,4-dihydrocarbostyril or a pharmaceutically acceptable acid addition salt thereof.
Claim 12
Dependent Claim
9 words
5-(3'-tert-Butylamino-2'-hydroxy)propoxy-8-benzyloxy-3,4-dihydrocarbostyril or a pharmaceutically acceptable acid addition salt thereof.
Claim 13
Dependent Claim
9 words
5-(3'-Isopropylamino-2'-hydroxy)propoxy-8-benzyloxy-3,4-dihydrocarbostyril or a pharmaceutically acceptable acid addition salt thereof.
Claim 14
Dependent Claim
9 words
5-(3'-Isopropylamino-2'-hydroxy)propoxy-8-benzyloxy-3,4-dihydrocarbostyril or a pharmaceutically acceptable acid addition salt thereof.
Claim 15
Dependent Claim
9 words
5-(3'-sec-Butylamino-2'-hydroxy)propoxy-8-benzyloxy-3,4-dihydrocarbostyril or a pharmaceutically acceptable acid addition salt thereof.
Claim 16
Dependent Claim
9 words
5-(3'-sec-Butylamino-2'-hydroxy)propoxy-8-benzyloxy-3,4-dihydrocarbostyril or a pharmaceutically acceptable acid addition salt thereof.
References Cited (Backward Citations)
GB1058822A
Cited
US3340266A
Cited
NL6400510A
Cited
JPS421182Y1
Cited
US3910924A
Cited
US3919239A
Cited
US3953456A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-02-06 | 1981-08-08 | 1982-02-07 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-02-06 | 1985-08-08 | 1986-02-07 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-02-06 | 1989-08-08 | 1990-02-07 | $7700.00 | Window Closed / Lapsed |