US4071622A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Treatment of a mammary or DMBA inducible tumor
Assignee: Abbott Laboratories
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Filing: 1976-02-11
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Granted: 1978-01-31
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Expires: 1996-02-11
Abstract
Abstract Certain nonapeptide amides were found which, upon administration at daily dosages of from about 1-200 μg/kg to warm-blooded animals, cause regression of DMBA-inducible or mammary tumors without causing adverse effects on healthy tissues.
Inventors
- 👤 Edwin Samuel Johnson
- 👤 John Hunter Seely
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 18:19
CPC Classifications
A; A61; A61K; A61K38/00; A61K38/04; A61K38/08
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
59 words
The method of reducing the size of a mammary or DMBA-inducible tumor in a warm-blooded animal by administering to an animal having a mammary or DMBA-inducible tumor an effective daily amount to reduce the size of such a tumor of a nonapeptide of the formula L-pGlu-L-His-L-Trp-L-Ser-L-Tyr-X-L-Leu-L-Arg-L-Pro-NH-C.sub.2 H.sub.5 wherein X denotes the optically active D-form of Tyr, Trp or Phe.
Claim 2
Independent Claim
59 words
The method of reducing the size of a mammary or DMBA-inducible tumor in a warm-blooded animal by administering to an animal having a mammary or DMBA-inducible tumor an effective daily amount to reduce the size of such a tumor of a nonapeptide of the formula L-pGlu-L-His-L-Trp-L-Ser-L-Tyr-X-L-Leu-L-Arg-L-Pro-NH-C.sub.2 H.sub.5 wherein X denotes the optically active D-form of Tyr, Trp or Phe.
Claim 3
Dependent Claim
9 words
The method of claim 1 wherein X is tyrosyl.
Claim 4
Dependent Claim
9 words
The method of claim 1 wherein X is tryptophyl.
Claim 5
Dependent Claim
9 words
The method of claim 1 wherein X is phenylalanyl.
Claim 6
Dependent Claim
12 words
The method of claim 1 wherein said tumor is a mammary tumor.
Claim 7
Dependent Claim
12 words
The method of claim 1 wherein said tumor is a DMBA-inducible tumor.
Claim 8
Dependent Claim
21 words
The method of claim 1 wherein said nonapeptide is administered at a daily parenteral dose of between 1 and 200 μg/kg.
Claim 9
Dependent Claim
17 words
The method of claim 7 wherein said parenteral dose is administered as solution in 0.9% of saline.
Claim 10
Dependent Claim
21 words
The method of claim 1 wherein said nonapeptide is administered at a daily oral dose of between 2 and 500 μg/kg.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-01-30 | 1981-08-01 | 1982-01-31 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-01-30 | 1985-08-01 | 1986-01-31 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-01-30 | 1989-08-01 | 1990-01-31 | $7700.00 | Window Closed / Lapsed |