US4071552A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Aryloxy aminobutanols, their preparation and use thereof
Assignee: Wyeth Canada Inc
•
Filing: 1976-05-19
•
Granted: 1978-01-31
•
Expires: 1996-05-19
Abstract
Abstract Disclosed herein are compounds of the formula ##STR1## in which Ar is phenyl or 1-naphthyl; R 1 is hydrogen or lower alkyl; and R 2 and R 3 are either the same or different selected from the group consisting of hydrogen or lower alkyl; with the proviso that when R 1 is lower alkyl then R 2 is the same lower alkyl. The compounds are antidepressant agents and methods for their preparation and use also are disclosed.
Inventors
- 👤 Jean-Marie Ferland
- 👤 Real Laliberte
- 👤 Wilbur Lippmann
- 👤 Thomas A. Pugsley
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 22:34
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/13; A61K31/135; C; C07; C07C; C07C233/00; C07C233/01; C07C233/16
Claims Analysis
Total Claims: 20
Claim 1
Independent Claim
107 words
A compound of Formula 1 ##STR5## in which Ar is phenyl or 1-naphthyl; R 1 is hydrogen or lower alkyl; and R 2 and R 3 are either the same or different selected from the group consisting of hydrogen or lower alkyl having 1-2 carbons; with the proviso that when Ar is 1-naphthyl then ##STR6## is selected from the group consisting of amino, ethylamino and dimethylamino; and with the proviso that when Ar is phenyl then ##STR7## is methylamino; and with the further proviso that when R 1 is lower alkyl then R 2 is the same lower alkyl; or a therapeutically acceptable acid addition salt thereof.
Claim 2
Dependent Claim
107 words
A compound of Formula 1 ##STR5## in which Ar is phenyl or 1-naphthyl; R 1 is hydrogen or lower alkyl; and R 2 and R 3 are either the same or different selected from the group consisting of hydrogen or lower alkyl having 1-2 carbons; with the proviso that when Ar is 1-naphthyl then ##STR6## is selected from the group consisting of amino, ethylamino and dimethylamino; and with the proviso that when Ar is phenyl then ##STR7## is methylamino; and with the further proviso that when R 1 is lower alkyl then R 2 is the same lower alkyl; or a therapeutically acceptable acid addition salt thereof.
Claim 3
Dependent Claim
6 words
2-Amino-4-(1-naphthyloxy)-1-butanol, as claimed in claim 1.
Claim 4
Dependent Claim
7 words
2-Amino-4-(1-naphthyloxy)-1-butanol hydrochloride, as claimed in claim 1.
Claim 5
Dependent Claim
6 words
2-(Methylamino)-4-phenoxy-1-butanol, as claimed in claim 1.
Claim 6
Dependent Claim
7 words
2-(Methylamino)-4-phenoxy-1-butanol maleate, as claimed in claim 1.
Claim 7
Dependent Claim
6 words
2-(Ethylamino)-4-(1-naphthyloxy)-1-butanol, as claimed in claim 1.
Claim 8
Dependent Claim
7 words
2-(Ethylamino)-4-(1-naphthyloxy)-1-butanol hydrochloride, as claimed in claim 1.
Claim 9
Dependent Claim
6 words
2-(Dimethylamino)-4-(1-naphthyloxy)-1-butanol, as claimed in claim 1.
Claim 10
Dependent Claim
7 words
2-(Dimethylamino)-4-(1-naphthyloxy)-1-butanol maleate, as claimed in claim 1.
Claim 11
Dependent Claim
6 words
1-Methoxy-N,N-dimethyl-4-(1-naphthyloxy)-2-butanamine, as claimed in claim 1.
Claim 12
Dependent Claim
7 words
1-Methoxy-N,N-dimethyl-4-(1-naphthyloxy)-2-butanamine hydrochloride, as claimed in claim 1.
Claim 13
Dependent Claim
1 words
2-(Methylamino)-4-(1-naphthyloxy)-1-butanol.
Claim 14
Dependent Claim
1 words
2-(Methylamino)-4-(1-naphthyloxy)-1-butanol.
Claim 15
Dependent Claim
2 words
2-(Methylamino)-4-(1-naphthyloxy)-1-butanol maleate.
Claim 16
Dependent Claim
2 words
2-(Methylamino)-4-(1-naphthyloxy)-1-butanol maleate.
Claim 17
Dependent Claim
1 words
2-(Ethylamino)-4-phenoxy-1-butanol.
Claim 18
Dependent Claim
1 words
2-(Ethylamino)-4-phenoxy-1-butanol.
Claim 19
Dependent Claim
2 words
2-(Ethylamino)-4-phenoxy-1-butanol hydrochloride.
Claim 20
Dependent Claim
2 words
2-(Ethylamino)-4-phenoxy-1-butanol hydrochloride.
References Cited (Backward Citations)
US3203992A
Cited
US3954872A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-01-30 | 1981-08-01 | 1982-01-31 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-01-30 | 1985-08-01 | 1986-01-31 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-01-30 | 1989-08-01 | 1990-01-31 | $7700.00 | Window Closed / Lapsed |