US4070496A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Phosphine oxides having a physiological cooling effect
Assignee: Warner Lambert Co LLC
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Filing: 1973-09-14
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Granted: 1978-01-24
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Expires: 1993-09-14
Abstract
Abstract Compounds and compositions are disclosed having a physiological cooling action on the skin. The compositions contain as the active ingredient certain phosphine oxides. The compositions disclosed include toilet and cosmetic preparations, e.g. toilet water, after-shave lotions, soaps, cosmetic creams and lotions, dentifrices and cleansing tissues, and tobacco and tobacco preparations.
Inventors
- 👤 David G. Rowsell
- 👤 David J. Spring
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 09:06
CPC Classifications
C; C07; C07F; C07F9/00; C07F9/02; C07F9/28; C07F9/50; C07F9/53; A; A23; A23L; A23L27/00; A23L27/20; A23L27/202; A23L27/203; A24; A24B; A24B15/00; A24B15/18; A24B15/28; A24B15/30; A61; A61K; A61K8/00; A61K8/02; A61K8/0208; A61K8/18; A61K8/30; A61K8/55; A61Q; A61Q19/00; A61K2800/00; A61K2800/20; A61K2800/24; A61K2800/244; A61Q11/00; A61Q13/00; A61Q15/00; A61Q19/002; A61Q5/00; A61Q5/02; A61Q9/00; A61Q9/02
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
160 words
In a manufactured consumer product for application to or consumption by the human body, said product comprising (a) a topically administrable or orally ingestible carrier and one or more of the following: a flavourant, colourant, odourant, antiseptic, antacid or analgesic, and (b) a compound capable of stimulating the cold receptors of the nervous system in the surface tissues of the body when brought into contact therewith by application or consumption of the said product, the improvement which comprises using as the cold receptor stimulating compound, an effective amount of a cold receptor stimulating phosphine oxide of the formula ##STR3## where R 1 is a straight chain alkyl group having from 4-8 carbon atoms inclusive; R 2 is a branched chain alkyl group having from 3-5 carbon atoms inclusive; and R 3 is an alkyl group having from 3-6 carbon atoms inclusive or cyclopentyl; R 1 , r 2 and R 3 together providing a total of from 13-16 carbon atoms.
Claim 2
Dependent Claim
160 words
In a manufactured consumer product for application to or consumption by the human body, said product comprising (a) a topically administrable or orally ingestible carrier and one or more of the following: a flavourant, colourant, odourant, antiseptic, antacid or analgesic, and (b) a compound capable of stimulating the cold receptors of the nervous system in the surface tissues of the body when brought into contact therewith by application or consumption of the said product, the improvement which comprises using as the cold receptor stimulating compound, an effective amount of a cold receptor stimulating phosphine oxide of the formula ##STR3## where R 1 is a straight chain alkyl group having from 4-8 carbon atoms inclusive; R 2 is a branched chain alkyl group having from 3-5 carbon atoms inclusive; and R 3 is an alkyl group having from 3-6 carbon atoms inclusive or cyclopentyl; R 1 , r 2 and R 3 together providing a total of from 13-16 carbon atoms.
Claim 3
Dependent Claim
76 words
A product according to claim 1, wherein the cold receptor stimulant is of the formula defineld, where R 1 is a straight chain alkyl group of from 5-8 carbon atoms inclusive, R 2 is selected from isopropyl, sec.-butyl, isobutyl and isopentyl, and R 3 is selected from branched chain alkyl groups of from 4-5 carbon atoms inclusive and cyclopentyl, R 1 , R 2 and R 3 together providing a total of from 13-16 carbon atoms.
Claim 4
Dependent Claim
54 words
A product according to claim 1, wherein the cold receptor stimulant is selected from: n-hexyl-isopropyl-cyclopentyl phosphine oxide; n-heptyl-isopropyl-cyclopentyl phosphine oxide; isobutyl-n-hexyl-cyclopentyl phosphine oxide; isobutyl-sec.-butyl-n-hexyl phosphine oxide; isobutyl-sec.-butyl-n-heptyl phosphine oxide; isobutyl-n-hexyl-isopentyl phosphine oxide; t.butyl-n-hexyl-isopentyl phosphine oxide; sec.butyl-n-heptyl-isopropyl phosphine oxide; sec.butyl-n-octyl-isopropyl phosphine oxide; isobutyl-sec.-butyl-n-octyl phosphine oxide; di-sec.-butyl-n-octyl phosphine oxide; sec.butyl-n-hexyl-isopropyl phosphine oxide; and n-hexyl-isopentyl-isopropyl phosphine oxide.
Claim 5
Dependent Claim
32 words
A product according to claim 1, which is a toilet lotion comprising an aqueous, alcoholic or aqueous-alcoholic base; an antiseptic, perfuming agent, colorant or mixture thereof; and said cold receptor stimulating compound.
Claim 6
Dependent Claim
31 words
A product according to claim 1, which is a cosmetic preparation comprising an oil-in-water emulsion cosmetic base; an antiseptic, perfuming agent, colorant or mixture thereof; and said cold receptor stimulating compound.
Claim 7
Dependent Claim
25 words
A product according to claim 1, which is a toilet soap, into which there is incorporated an effective amount of said cold receptor stimulating compound.
Claim 8
Dependent Claim
28 words
A product according to claim 1, which is a shaving soap, foam or cream into which there is incorporated an effective amount of said cold receptor stimulating compound.
Claim 9
Dependent Claim
37 words
A product according to claim 1, which is an edible or potable preparation comprising an edible or potable base; a flavorant on colorant or a mixture thereof, and an effective amount of said cold receptor stimulating compound.
Claim 10
Dependent Claim
25 words
A product according to claim 1, which is a chewing gum into which there is incorporated an effective amount of said cold receptor stimulating compound.
Claim 11
Dependent Claim
35 words
A method of stimulating the cold receptors of the nervous system of the human body which comprises applying thereto an effective amount of a cold receptor stimulating compound of the formula defined in claim 1.
References Cited (Backward Citations)
US3158461A
Cited
GB976974A
Cited
US3331878A
Cited
US3304263A
Cited
US3326768A
Cited
US3338701A
Cited
US3644653A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-01-23 | 1981-07-25 | 1982-01-24 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-01-23 | 1985-07-25 | 1986-01-24 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-01-23 | 1989-07-25 | 1990-01-24 | $7700.00 | Window Closed / Lapsed |