US4070450A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Sunscreening compound and method
Assignee: Hoffmann La Roche Inc
•
Filing: 1975-12-22
•
Granted: 1978-01-24
•
Expires: 1995-12-22
Abstract
Abstract Radiation screening preparations comprising a cosmetically acceptable carrier and, as the active ingredient, one or more compounds represented by the formula <IMAGE> WHEREIN N IS 1, R1 is hydrogen, alkyl, alkali metal, ammonium or ammonium substituted with one or more alkyl or hydroxyalkyl residues, R2 is hydroxymethyl or alkoxymethyl and R3 is hydrogen; or R1 and R2 together constitute a methylene group and R3 is hydrogen, methyl or ethyl; and wherein n is 2, R1 is an alkaline earth metal, R2 is hydroxymethyl or alkoxymethyl and R3 is hydrogen AND PHARMACEUTICALLY ACCEPTABLE ACID ADDITION SALTS THEREOF. The preparations may additionally contain other agents which are characterized by a maximum light absorption in the erythemal range. Certain novel compounds are disclosed.
Inventors
- 👤 Richard Barner
- 👤 Walter Boguth
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-30 11:10
CPC Classifications
C; C07; C07D; C07D213/00; C07D213/02; C07D213/04; C07D213/60; C07D213/62; C07D213/63; C07D213/65; C07D213/66; C07D213/78; C07D213/79
Claims Analysis
Total Claims: 18
Claim 1
Independent Claim
167 words
A method of protecting skin from erythma inducing ultraviolet radiation which comprises applying to the skin an amount of a sunscreen composition sufficient for the protection thereof, said composition comprising an inert. dermatologically acceptable carrier selected from the group consisting of a cream, a milk, an ointment, a gel, a lotion, a spray and an aerosol and from about 1% by weight to about 25% by weight of an active ingredient consisting essentially of one or more compounds represented by the formula ##STR7## wherein n is 1, R 1 is hydrogen, alkyl, alkali metal, ammonium or ammonium substituted with one or more alkyl or hydroxy alkyl residues, R 2 is hydroxymethyl or alkoxymethyl and R 3 is hydrogen; or R 1 and R 2 together represent a methylene group and R 3 is hydrogen, methyl or ethyl; and wherein n is 2, R 1 is an alkaline earth metal, R 2 is hydroxymethyl or alkoxymethyl and R 3 is hydrogen; and pharmaceutically acceptable acid addition salts thereof.
Claim 2
Independent Claim
167 words
A method of protecting skin from erythma inducing ultraviolet radiation which comprises applying to the skin an amount of a sunscreen composition sufficient for the protection thereof, said composition comprising an inert. dermatologically acceptable carrier selected from the group consisting of a cream, a milk, an ointment, a gel, a lotion, a spray and an aerosol and from about 1% by weight to about 25% by weight of an active ingredient consisting essentially of one or more compounds represented by the formula ##STR7## wherein n is 1, R 1 is hydrogen, alkyl, alkali metal, ammonium or ammonium substituted with one or more alkyl or hydroxy alkyl residues, R 2 is hydroxymethyl or alkoxymethyl and R 3 is hydrogen; or R 1 and R 2 together represent a methylene group and R 3 is hydrogen, methyl or ethyl; and wherein n is 2, R 1 is an alkaline earth metal, R 2 is hydroxymethyl or alkoxymethyl and R 3 is hydrogen; and pharmaceutically acceptable acid addition salts thereof.
Claim 3
Dependent Claim
25 words
A method in accordance with claim 1 wherein said active ingredient comprises from about 2% by weight to about 6% by weight of said composition.
Claim 4
Dependent Claim
39 words
A method in accordance with claim 1 wherein n is 1, R 1 is hydrogen, alkali metal or ammonium substituted with one or more alkyl or hydroxyalkyl residues, R 2 is hydroxymethyl or alkoxymethyl and R 3 is hydrogen.
Claim 5
Dependent Claim
29 words
A method in accordance with claim 1 wherein n is 2, R 1 is an alkaline earth metal, R 2 is hydroxymethyl or alkoxymethyl and R 3 is hydrogen.
Claim 6
Dependent Claim
14 words
A method in accordance with claim 1 wherein said active ingredient is 4-pyridoxic acid.
Claim 7
Dependent Claim
13 words
A method in accordance with claim 1 wherein said active ingredient is sodium-4-pyridoxinate.
Claim 8
Dependent Claim
13 words
A method in accordance with claim 1 wherein said active ingredient is potassium-4-pyridoxinate.
Claim 9
Dependent Claim
13 words
A method in accordance with claim 1 wherein said active ingredient is triethanolammonium-4-pyridoxinate.
Claim 10
Dependent Claim
14 words
A method in accordance with claim 1 wherein said active ingredient is 5-O-cetyl-4-pyridoxic acid.
Claim 11
Dependent Claim
13 words
A method in accordance with claim 1 wherein said active ingredient is methyl-4-pyridoxinate.
Claim 12
Dependent Claim
13 words
A method in accordance with claim 1 wherein said active ingredient is n-hexyl-4-pyridoxinate.
Claim 13
Dependent Claim
16 words
A method in accordance with claim 1 wherein said active ingredient is 4-pyridoxic acid lactone hydrochloride.
Claim 14
Dependent Claim
16 words
A method in accordance with claim 1 wherein said active ingredient is 4-pyridoxic acid lactone-3-methyl ether.
Claim 15
Dependent Claim
13 words
A method in accordance with claim 1 wherein said active ingredient is sodium-5-O-cetyl-4-pyridoxinate.
Claim 16
Dependent Claim
13 words
A method in accordance with claim 1 wherein said active ingredient is tris(hydroxymethyl)aminomethane-4-pyridoxinate.
Claim 17
Dependent Claim
102 words
A compound represented by the formula ##STR8## wherein n is 1, R' 1 is hydrogen, alkyl, alkali metal, ammonium or ammonium substituted with one or more alkyl or hydroxyalkyl residues, R' 2 is hydroxymethyl or alkoxymethyl and R' 3 is hydrogen with the proviso that, R' 2 is not hydroxymethyl in case R' 1 is hydrogen; or R' 1 and R' 2 together represent a methylene group and R' 3 is ethyl, and wherein n is 2, R' 1 is an alkaline earth metal, R' 2 is hydroxymethyl or alkoxymethyl and R' 3 is hydrogen and pharmaceutically acceptable acid addition salts thereof.
Claim 18
Dependent Claim
102 words
A compound represented by the formula ##STR8## wherein n is 1, R' 1 is hydrogen, alkyl, alkali metal, ammonium or ammonium substituted with one or more alkyl or hydroxyalkyl residues, R' 2 is hydroxymethyl or alkoxymethyl and R' 3 is hydrogen with the proviso that, R' 2 is not hydroxymethyl in case R' 1 is hydrogen; or R' 1 and R' 2 together represent a methylene group and R' 3 is ethyl, and wherein n is 2, R' 1 is an alkaline earth metal, R' 2 is hydroxymethyl or alkoxymethyl and R' 3 is hydrogen and pharmaceutically acceptable acid addition salts thereof.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-01-23 | 1981-07-25 | 1982-01-24 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-01-23 | 1985-07-25 | 1986-01-24 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-01-23 | 1989-07-25 | 1990-01-24 | $7700.00 | Window Closed / Lapsed |