US4070246A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Reactive matrices
Assignee: Abbott Laboratories
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Filing: 1976-04-09
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Granted: 1978-01-24
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Expires: 1996-04-09
Abstract
Abstract Compositions comprising stable, water-insoluble coatings on substrates to which biologically active proteins can be covalently coupled so that the resultant product has the biological properties of the protein and the mechanical properties of the substrate, for example, magnetic properties of a metal support. The resultant product can be utilized in diagnostic immunoassays as an example, and when the metal substrate is magnetic, the product can be removed from liquid media by a magnetic field ensuring that any washing or incubation process can be finished promptly and efficiently.
Inventors
- 👤 John Frederick Kennedy
- 👤 Martin Frank Chaplin
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 11:25
CPC Classifications
G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/53; G01N33/543; G01N33/54313; G01N33/54326; C; C12; C12N; C12N11/00; C12N11/14; G01N33/551; G01N33/553; Y; Y10; Y10S; Y10S428/00; Y10S428/90; Y10T; Y10T428/00; Y10T428/29; Y10T428/2913; Y10T428/2933; Y10T428/2938; Y10T428/294; Y10T428/31504; Y10T428/31678; Y10T428/31688
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
37 words
A composition comprising a water-insoluble metal substrate, the surface of which is coated with a condensation product of an aminobenzoic acid with an aldehyde, which composition is suitable for coupling with an organic compound having biological activity.
Claim 2
Dependent Claim
37 words
A composition comprising a water-insoluble metal substrate, the surface of which is coated with a condensation product of an aminobenzoic acid with an aldehyde, which composition is suitable for coupling with an organic compound having biological activity.
Claim 3
Dependent Claim
19 words
A composition as claimed in claim 1, wherein the metal of the substrate is nickel, cobalt, iron or aluminium.
Claim 4
Dependent Claim
15 words
A composition as claimed in claim 1, wherein the metal of the substrate is ferromagnetic.
Claim 5
Dependent Claim
17 words
A composition as claimed in claim 2, wherein the metal substrate is in rod or powder form.
Claim 6
Dependent Claim
12 words
A composition as claimed in claim 1, wherein the aldehyde is formaldehyde.
Claim 7
Dependent Claim
15 words
A composition as claimed in claim 1 which is suitable for coupling with a protein.
Claim 8
Dependent Claim
38 words
A method of making the composition claimed in claim 1, which method comprises adding the aldehyde slowly to an aqueous solution of the aminobenzoic acid containing the metal substrate, and recovering the coated metal product from the liquid.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-01-23 | 1981-07-25 | 1982-01-24 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-01-23 | 1985-07-25 | 1986-01-24 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-01-23 | 1989-07-25 | 1990-01-24 | $7700.00 | Window Closed / Lapsed |