US4066743A
Expired / Lapsed
US
⏱️ 0.0 years remaining
X-ray contrast agents
Assignee: Mallinckrodt Inc
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Filing: 1976-06-21
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Granted: 1978-01-03
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Expires: 1996-06-21
Abstract
Abstract 3-Acetamido-5-(4,4-bishydroxymethyl-2-oxazolinyl)-2,4,6-triiodobenzoic acid, 3-acetamido-5-(4-methyl-4-hydroxymethyl-2-oxazolinyl)-2,4,6-triiodoben zoic acid, analogous compounds and salts and esters thereof are useful as X-ray contrast agents. The corresponding acyl halides are useful as intermediates.
Inventors
- 👤 Mills T. Kneller
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 21:47
CPC Classifications
C; C07; C07D; C07D263/00; C07D263/02; C07D263/08; C07D263/10; C07D263/14
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
50 words
A compound of the formula: ##STR5## wherein R 1 is hydroxymethyl and R 2 is selected from the group consisting of hydroxymethyl and a lower alkyl group containing between 1 and 4 carbon atoms, and esters thereof with lower alkanols, salts thereof with pharmaceutically acceptable cations, and acyl halides thereof.
Claim 2
Dependent Claim
50 words
A compound of the formula: ##STR5## wherein R 1 is hydroxymethyl and R 2 is selected from the group consisting of hydroxymethyl and a lower alkyl group containing between 1 and 4 carbon atoms, and esters thereof with lower alkanols, salts thereof with pharmaceutically acceptable cations, and acyl halides thereof.
Claim 3
Dependent Claim
11 words
A compound as defined in claim 1 which is 3-acetamido-5-(4,4-bishydroxymethyl-2-oxazolinyl)-2,4,6-triiodobenzoic acid.
Claim 4
Dependent Claim
19 words
A compound as defined in claim 1 which is a salt of 3-acetamido-5-(4,4-bishydroxymethyl-2-oxazolinyl)-2,4,6-triiodobenzoic acid with a pharmaceutically acceptable cation.
Claim 5
Dependent Claim
14 words
A compound as defined in claim 3 wherein the pharmaceutically acceptable cation is sodium.
Claim 6
Dependent Claim
14 words
A compound as defined in claim 3 wherein the pharmaceutically acceptable cation is N-methylglucamine.
Claim 7
Dependent Claim
11 words
A compound as defined in claim 1 which is 3-acetamido-5-(4-methyl-4-hydroxymethyl-2-oxazolinyl)-2,4,6-triiodobenzoic acid.
Claim 8
Dependent Claim
19 words
A compound as defined in claim 1 which is a salt of 3-acetamido-5-(4-methyl-4-hydroxymethyloxazolinyl)-2,4,6-triiodobenzoic acid with a pharmaceutically acceptable cation.
Claim 9
Dependent Claim
14 words
A compound as defined in claim 7 wherein the pharmaceutically acceptable cation is sodium.
Claim 10
Dependent Claim
14 words
A compound as defined in claim 7 wherein the pharmaceutically acceptable cation is N-methylglucamine.
Claim 11
Dependent Claim
32 words
An X-ray contrast medium comprising an aqueous solution of a salt of a compound selected from the group consisting of 3-acetamido-5-(4,4-bishydroxymethyl-2-oxazolinyl)-2,4,6-triiodobenzoic acid and 3-acetamido-5-(4-methyl-4-hydroxymethyl-2-oxazolinyl)-2,4,6-triiodobenzoic acid with at least one pharmaceutically acceptable cation.
Claim 12
Dependent Claim
32 words
An X-ray contrast medium comprising an aqueous solution of a salt of a compound selected from the group consisting of 3-acetamido-5-(4,4-bishydroxymethyl-2-oxazolinyl)-2,4,6-triiodobenzoic acid and 3-acetamido-5-(4-methyl-4-hydroxymethyl-2-oxazolinyl)-2,4,6-triiodobenzoic acid with at least one pharmaceutically acceptable cation.
Claim 13
Dependent Claim
15 words
An X-ray contrast medium as defined by claim 10 wherein said compound is 3-acetamido-5-(4,4-bishydroxymethyl-2-oxazolinyl)-2,4,6-triiodobenzoic acid.
Claim 14
Dependent Claim
15 words
An X-ray contrast medium as defined by claim 10 wherein said compound is 3-acetamido-5-(4-methyl-4-hydroxymethyl-2-oxazolinyl)-2,4,6-triiodobenzoic acid.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-01-02 | 1981-07-04 | 1982-01-03 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-01-02 | 1985-07-04 | 1986-01-03 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-01-02 | 1989-07-04 | 1990-01-03 | $7700.00 | Window Closed / Lapsed |