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US4062941A Expired / Lapsed US ⏱️ 0.0 years remaining

Method for treating fungal infections using cell lytic enzymes

Assignee: GD Searle and Co Ltd
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Filing: 1976-05-24
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Granted: 1977-12-13
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Expires: 1996-05-24
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Abstract

Abstract The present invention encompasses a method for treating fungal infections in animals comprising administering to animals in need of antifungal treatment an effective amount of fungal cell lytic enzymes extracted from Coprinus, Lycoperdon, or Bolbitius in conjunction with conventional antimycotic agents such as amphotericin B or Nystatin. The fungal cell lytic enzymes are extracted from Coprinus, Lycoperdon, and Bolbitius by conventional enzyme isolation techniques. These fungal cell lytic enzymes retain their activity in vivo, are relatively non toxic and destroy fungi by degrading fungal cell walls and weakening the fungal cell walls so that conventional antimycotic agents are far more effective. The method of the present invention is particularly useful in treating infections by opportunistic fungi such as Aspergillus fumigatus and Candida albicans.

Inventors

  • 👤 David Allen Lewis Davies

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-11-05 12:23
CPC Classifications
C; C12; C12N; C12N9/00; C12N9/14; A; A61; A61K; A61K31/00; A61K31/70; A61K31/7042; A61K31/7048; A61K38/00; A61K38/16; A61K38/43; A61K38/44; A61K38/46; Y; Y10; Y10S; Y10S435/00; Y10S435/8215; Y10S435/911

Claims Analysis

Total Claims: 9
Claim 1
Independent Claim 31 words
A method for treating fungal infections in animals comprising administering to an animal in need of antifungal treatment an effective amount of fungal cell lytic enzymes extracted from Coprinus or Lycoperdon.
Claim 2
Independent Claim 31 words
A method for treating fungal infections in animals comprising administering to an animal in need of antifungal treatment an effective amount of fungal cell lytic enzymes extracted from Coprinus or Lycoperdon.
Claim 3
Independent Claim 37 words
A method for treating fungal infections in animals comprising administering to an animal in need of antifungal treatment an effective amount of fungal cell lytic enzymes extracted from Coprinus or Lycoperdon in conjunction with an antimycotic agent.
Claim 4
Independent Claim 37 words
A method for treating fungal infections in animals comprising administering to an animal in need of antifungal treatment an effective amount of fungal cell lytic enzymes extracted from Coprinus or Lycoperdon in conjunction with an antimycotic agent.
Claim 5
Dependent Claim 41 words
A method according to claim 2 for treating fungal infections in animals comprising administering to an animal in need of antifungal treatment an effective amount of fungal cell lytic enzymes extracted from Coprinus or Lycoperdon in conjunction with amphotericin-B or nystatin.
Claim 6
Dependent Claim 17 words
A method according to claim 2 wherein the fungal cell lytic enzyme is extracted from Lycoperdon pyriforme.
Claim 7
Dependent Claim 17 words
A method according to claim 2 wherein the fungal cell lytic enzyme is extracted from Coprinus comatus.
Claim 8
Dependent Claim 44 words
In a method for treating fungal infections by the administration of nystatin, amphotericin-B, or griseofulvin as antifungal agents, the improvement of which comprises the administration of effective amounts of fungal cell lytic anzymes extracted from Coprinus or Lycoperdon in conjunction with the antifungal agent.
Claim 9
Dependent Claim 44 words
In a method for treating fungal infections by the administration of nystatin, amphotericin-B, or griseofulvin as antifungal agents, the improvement of which comprises the administration of effective amounts of fungal cell lytic anzymes extracted from Coprinus or Lycoperdon in conjunction with the antifungal agent.

References Cited (Backward Citations)

No citation records indexed.

USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 1980-12-12 1981-06-13 1981-12-13 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 1984-12-12 1985-06-13 1985-12-13 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 1988-12-12 1989-06-13 1989-12-13 $7700.00 Window Closed / Lapsed

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