US4061637A
Expired / Lapsed
US
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Certain 4-aryl-5-(4-phenylpiperazino)alkyl-4-thiazolin-2-ones
Assignee: Istituto Luso Farmaco dItalia SpA
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Filing: 1975-05-12
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Granted: 1977-12-06
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Expires: 1995-05-12
Abstract
Abstract The invention provides novel 4-aryl-5-aminoalkyl-4-thiazolin-2-ones and their salts and complexes which have activity on the central nervous system, the cardio-vascular system, and anti-inflammatory, adrenolytic and anti-ulcer activity.
Inventors
- 👤 Elso Manghisi
- 👤 Giuseppe Cascio
- 👤 Giancarlo Fregnan
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 12:00
CPC Classifications
C; C07; C07D; C07D491/00; C07D491/02; C07D491/10; A; A61; A61P; A61P1/00; A61P1/04; A61P29/00; C07D277/00; C07D277/02; C07D277/20; C07D277/32; C07D277/34; C07D277/36
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
70 words
4-Aryl-5-aminoalkyl-4-thiazoline-2-ones of the formula: ##STR10## and their pharmaceutically acceptable salts, in which Ar represents phenyl, lower alkylphenyl, trifluoromethylphenyl, lower alkoxyphenyl, lower dialkylaminophenyl, halogen phenyl or lower alkylmercaptophenyl; Alk represents a saturated or unsaturated, linear or branched chain of 1 to 3 carbon atoms; ##STR11## is a piperazine-4 subsituted by phenyl; Z represents an oxygen or sulfur atom; and R 3 represents a hydrogen atom or methyl, acetyl, benzoyl or methylaminocarbonyl.
Claim 2
Dependent Claim
70 words
4-Aryl-5-aminoalkyl-4-thiazoline-2-ones of the formula: ##STR10## and their pharmaceutically acceptable salts, in which Ar represents phenyl, lower alkylphenyl, trifluoromethylphenyl, lower alkoxyphenyl, lower dialkylaminophenyl, halogen phenyl or lower alkylmercaptophenyl; Alk represents a saturated or unsaturated, linear or branched chain of 1 to 3 carbon atoms; ##STR11## is a piperazine-4 subsituted by phenyl; Z represents an oxygen or sulfur atom; and R 3 represents a hydrogen atom or methyl, acetyl, benzoyl or methylaminocarbonyl.
Claim 3
Dependent Claim
40 words
A compound of claim 1, wherein Ar is phenyl, p-fluorophenyl, p-chlorophenyl or p-methoxyphenyl; Alk is CH 2 or CH 2 CH 2 ; NR 1 R 2 is N'-phenylpiperazino; Z is oxygen; and R 3 is hydrogen, methyl or acetyl.
Claim 4
Dependent Claim
14 words
A compound according to claim 1 which is 4-p-fluorophenyl-5-β-(N'-phenylpiperazino)ethyl-4-thiazolin-2-one, and its pharmaceutically acceptable salts.
Claim 5
Dependent Claim
14 words
A compound according to claim 1 which is 4-phenyl-5-β-(N'-phenylpiperazino)ethyl-4-thiazolin-2-one, and its pharmaceutically acceptable salts.
Claim 6
Dependent Claim
14 words
A compound according to claim 1 which is 4-p-chlorophenyl-5-β-(N'-phenylpiperazino)ethyl-4-thiazolin-2-one, and its pharmaceutically acceptable salts.
Claim 7
Dependent Claim
14 words
A compound according to claim 1 which is 4-p-methoxyphenyl-5-β-(N'-phenylpiperazino)ethyl-4-thiazolin-2-one, and its pharmaceutically acceptable salts.
Claim 8
Dependent Claim
14 words
A compound according to claim 1 which is 3-methyl-4-p-fluorophenyl-5-β-(N'-phenylpiperazino)ethyl-4-thiazolin-2-one, and its pharmaceutically acceptable salts.
Claim 9
Dependent Claim
14 words
A compound according to claim 1 which is 4-p-chlorophenyl-5-(N'-phenylpiperazino)methyl-4-thiazolin-2-one, and its pharmaceutically acceptable salts.
Claim 10
Dependent Claim
14 words
A compound according to claim 1, which is 3-methyl-4-p-fluorophenyl-5-β-(N'-phenylpiperazino)ethyl-4-thiazoline-2-thione, and its pharmaceutically acceptable salts.
References Cited (Backward Citations)
US2921936A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-12-05 | 1981-06-06 | 1981-12-06 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-12-05 | 1985-06-06 | 1985-12-06 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-12-05 | 1989-06-06 | 1989-12-06 | $7700.00 | Window Closed / Lapsed |