US4060603A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Histidine derivatives
Assignee: Reckitt Benckiser Healthcare UK Ltd
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Filing: 1976-02-20
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Granted: 1977-11-29
•
Expires: 1996-02-20
Abstract
Abstract Compounds of the formula ##STR1## wherein R, R 1 , R 2 , R 3 and R 4 represent certain specified substituent groups. The compounds exhibit activity in the reserpine induced hypothermia test.
Inventors
- 👤 Barry A. Morgan
- 👤 Derek J. Schafer
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-30 18:36
CPC Classifications
C; C07; C07K; C07K5/00; C07K5/04; C07K5/08; C07K5/0821; C07K5/0825
Claims Analysis
Total Claims: 24
Claim 1
Independent Claim
56 words
Compounds of the formula: ##STR5## wherein R is hydrogen or alkyl C 1-3 ; R 1 is alkyl or alkoxy C 1-3 ; R 2 is hydrogen, alkyl or alkoxy C 1-3 ; R 3 is hydrogen, alkyl C 1-6 , or cycloalkyl C 3-6 ; and R 4 is hydrogen or alkyl C 1-6 .
Claim 2
Dependent Claim
56 words
Compounds of the formula: ##STR5## wherein R is hydrogen or alkyl C 1-3 ; R 1 is alkyl or alkoxy C 1-3 ; R 2 is hydrogen, alkyl or alkoxy C 1-3 ; R 3 is hydrogen, alkyl C 1-6 , or cycloalkyl C 3-6 ; and R 4 is hydrogen or alkyl C 1-6 .
Claim 3
Dependent Claim
33 words
Compounds of the formula: ##STR6## wherein R is hydrogen or alkyl C 1-3 ; R 1 is alkyl or alkoxy C 1-3 ; R 2 is hydrogen, alkyl or alkoxy C 1-3 .
Claim 4
Dependent Claim
33 words
Compounds of the formula: ##STR6## wherein R is hydrogen or alkyl C 1-3 ; R 1 is alkyl or alkoxy C 1-3 ; R 2 is hydrogen, alkyl or alkoxy C 1-3 .
Claim 5
Dependent Claim
53 words
Compounds of the formula: ##STR7## wherein R is hydrogen or alkyl C 1-3 ; R 1 is alkyl C 1-3 ; R 2 is hydrogen or alkyl C 1-3 ; R 3 is hydrogen, alkyl C 1-6 , or cycloalkyl C 3-6 ; and R 4 is hydrogen or alkyl C 1-6 .
Claim 6
Dependent Claim
53 words
Compounds of the formula: ##STR7## wherein R is hydrogen or alkyl C 1-3 ; R 1 is alkyl C 1-3 ; R 2 is hydrogen or alkyl C 1-3 ; R 3 is hydrogen, alkyl C 1-6 , or cycloalkyl C 3-6 ; and R 4 is hydrogen or alkyl C 1-6 .
Claim 7
Dependent Claim
40 words
A compound of Formula I as claimed in claim 3 wherein R is hydrogen or methyl; R 1 is methyl or ethyl; R 2 is hydrogen of methyl; R 3 is hydrogen, hexyl or cyclohexyl; and R 4 is hydrogen.
Claim 8
Dependent Claim
22 words
A pharmaceutical composition which comprises a compound of Formula I as claimed in claim 3 and a pharmaceutically acceptable diluent or carrier.
Claim 9
Dependent Claim
30 words
Compounds of the formula: ##STR8## wherein R is hydrogen or alkyl C 1-3 ; R 1 is alkyl C 1-3 ; R 2 is hydrogen or alkyl C 1-3 .
Claim 10
Dependent Claim
30 words
Compounds of the formula: ##STR8## wherein R is hydrogen or alkyl C 1-3 ; R 1 is alkyl C 1-3 ; R 2 is hydrogen or alkyl C 1-3 .
Claim 11
Dependent Claim
29 words
A compound of Formula Ia as claimed in claim 6 wherein R is hydrogen or methyl; R 1 is methyl or ethyl; and R 2 is hydrogen or methyl.
Claim 12
Dependent Claim
1 words
L-Pyroglutamyl-L-histidyl-trans-3-methyl-L-prolineamide.
Claim 13
Dependent Claim
1 words
L-Pyroglutamyl-L-histidyl-trans-3-methyl-L-prolineamide.
Claim 14
Dependent Claim
1 words
L-Pyroglutamyl-L-histidyl-trans-3-ethyl-dl-prolineamide.
Claim 15
Dependent Claim
1 words
L-Pyroglutamyl-L-histidyl-trans-3-ethyl-dl-prolineamide.
Claim 16
Dependent Claim
1 words
L-Pyroglutamyl-L-histidyl-3,3-dimethyl-dl-prolineamide.
Claim 17
Dependent Claim
1 words
L-Pyroglutamyl-L-histidyl-3,3-dimethyl-dl-prolineamide.
Claim 18
Dependent Claim
2 words
L-Pyroglutamyl-N.sup.α -methyl-L-histidyl-trans-3-methyl-L-prolineamide.
Claim 19
Dependent Claim
2 words
L-Pyroglutamyl-N.sup.α -methyl-L-histidyl-trans-3-methyl-L-prolineamide.
Claim 20
Dependent Claim
1 words
L-Pyroglutamyl-L-histidyl-trans-3-methyl-L-prolinecyclohexylamide.
Claim 21
Dependent Claim
1 words
L-Pyroglutamyl-L-histidyl-trans-3-methyl-L-prolinecyclohexylamide.
Claim 22
Dependent Claim
1 words
L-Pyroglutamyl-L-histidyl-trans-3-methyl-L-prolinehexylamide.
Claim 23
Dependent Claim
1 words
L-Pyroglutamyl-L-histidyl-trans-3-methyl-L-prolinehexylamide.
Claim 24
Dependent Claim
25 words
A pharmaceutical composition as claimed in claim 5 in unit dosage form for oral administration which comprises from 1 to 100 mg of said compound.
References Cited (Backward Citations)
US3931139A
Cited
US3959248A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-11-28 | 1981-05-30 | 1981-11-29 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-11-28 | 1985-05-30 | 1985-11-29 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-11-28 | 1989-05-30 | 1989-11-29 | $7700.00 | Window Closed / Lapsed |