US4060532A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Halogenated dioxolane tranquilizers
Assignee: Zeneca Inc
•
Filing: 1972-03-28
•
Granted: 1977-11-29
•
Expires: 1992-03-28
Abstract
Abstract Halogenated dioxolane compounds having perhalogenated groups in the 2-position and other substituted groups, for example, carbamate and nitrate in the 4 and/or 5-position are disclosed. These compounds are useful as tranquilizers.
Inventors
- 👤 Ludwig A. Hartmann
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-30 21:36
CPC Classifications
C; C07; C07D; C07D317/00; C07D317/08; C07D317/10; C07D317/14; C07D317/28; C07D317/16; C07D317/18; C07D317/20; C07D317/22; C07D317/24; C07D317/32; C07D317/34; C07D317/36
Claims Analysis
Total Claims: 18
Claim 1
Independent Claim
137 words
A compound of the formula ##STR22## wherein each R 1 is independently selected from the group consisting of perhalogenated alkyl radicals having from 1 to 7 carbon atoms and wherein each halogen atom has an atomic weight of at most 80, A is an alkylene radical having from 1 to 6 carbon atoms, R 6 is selected from the group consisting of ##STR23## where R 4 is selected from the group consisting of lower alkyl radicals having from 1 to 4 carbon atoms, phenyl, tolyl, mono-chlorophenyl, and cyclohexyl, R 5 is selected from the group consisting of hydrogen, alkyl having no more than 6 carbon atoms and --A--R 6 , R 7 is hydrogen and R 8 is independently selected from the group consisting of hydrogen and lower alkyl radicals having from 1 to 4 carbon atoms,
Claim 2
Dependent Claim
137 words
A compound of the formula ##STR22## wherein each R 1 is independently selected from the group consisting of perhalogenated alkyl radicals having from 1 to 7 carbon atoms and wherein each halogen atom has an atomic weight of at most 80, A is an alkylene radical having from 1 to 6 carbon atoms, R 6 is selected from the group consisting of ##STR23## where R 4 is selected from the group consisting of lower alkyl radicals having from 1 to 4 carbon atoms, phenyl, tolyl, mono-chlorophenyl, and cyclohexyl, R 5 is selected from the group consisting of hydrogen, alkyl having no more than 6 carbon atoms and --A--R 6 , R 7 is hydrogen and R 8 is independently selected from the group consisting of hydrogen and lower alkyl radicals having from 1 to 4 carbon atoms,
Claim 3
Dependent Claim
12 words
A compound of claim 1 wherein R 6 is a carbamoyloxy radical.
Claim 4
Dependent Claim
28 words
A compound of claim 1 wherein R 1 radical contains one carbon atom, R 5 , R 7 and R 8 are hydrogen and R 6 is ##STR24##
Claim 5
Dependent Claim
8 words
A compound of claim 1 which is 2,2-bis(trifluoromethyl)-4-carbamoyloxymethyl-1,3-dioxolane.
Claim 6
Dependent Claim
8 words
A compound of claim 1 which is 2,2-bis(trifluoromethyl)-4-(N-phenylcarbamoyloxymethyl)-1,3-dioxolane.
Claim 7
Dependent Claim
8 words
A compond of claim 1 which is 2,2-bis(chlorodifluoromethyl)-4-carbamoyloxymethyl-1,3-dioxolane.
Claim 8
Dependent Claim
8 words
A compound of claim 1 which is 2-chlorodifluoromethyl-2-dichlorofluoromethyl-4-carbamoyloxymethyl-1,3-dioxolane.
Claim 9
Dependent Claim
8 words
A compound of claim 1 which is 2,2-bis(trifluoromethyl)-4-(carbamoyloxyethyl)-1,3-dioxolane.
Claim 10
Dependent Claim
9 words
A compound of claim 1 which is α-ethyl-γ,5,5-trimethyl-2,2-bis(trifluoromethyl)-1,3-dioxolane-4-pentanol carbamate.
Claim 11
Dependent Claim
8 words
A compound of claim 1 which is 2,2-bis(chlorodifluoromethyl)-4-carbamoyl-oxymethyl-1,3-dioxolane.
Claim 12
Dependent Claim
8 words
A compound of claim 1 which is 2,2-bis(chlorodifluoromethyl)-4-[N-(p-chlorophenyl)carbamoyloxymethyl]-1,3-dioxolane.
Claim 13
Dependent Claim
9 words
A compound of claim 1 which is α,α,5-trimethyl-2,2-bis(chlorodifluoromethyl)1,3-dioxolane-4-methanol carbamate.
Claim 14
Dependent Claim
8 words
A compound of claim 1 which is 2,2-bis(chlorodifluoromethyl)-4,5-bis(1-carbamoyloxyethyl)-1,3-dioxolane.
Claim 15
Dependent Claim
8 words
A compound of claim 1 which is 2,2-bis(heptafluoropropyl)-4-carbamoyloxymethyl-1,3-dioxolane.
Claim 16
Dependent Claim
10 words
A compound of claim 1 wherein R 4 is phenyl.
Claim 17
Dependent Claim
29 words
A compound of claim 1 wherein R 5 , R 7 and R 8 are hydrogen and A is an alkylene group containing from 1 to 6 carbon atoms.
Claim 18
Dependent Claim
12 words
A compound of claim 16 wherein R 6 is the carbamoyloxy radical.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-11-28 | 1981-05-30 | 1981-11-29 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-11-28 | 1985-05-30 | 1985-11-29 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-11-28 | 1989-05-30 | 1989-11-29 | $7700.00 | Window Closed / Lapsed |