US4060526A
Expired / Lapsed
US
⏱️ 0.0 years remaining
1-Heterocyclic alkyl-1,2,3,4-tetrahydroquinazolinones and analgesic intermediates thereof
Assignee: Fisons Corp
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Filing: 1976-08-23
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Granted: 1977-11-29
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Expires: 1996-08-23
Abstract
Abstract 1-heterocyclic alkyl-1,2,3,4-tetrahydroquinazolinones, acid addition salts thereof, and intermediate compounds having analgesic properties. A representative quinazolinone compound is 1-[2-(1-phenyl-4-piperazinyl)-ethyl]-2-phenyl-1,2,3,4-tetrahydro-4-quinazolinone. A representative analgesic intermediate is 2-[2-(4-[1-phenyl]piperazinyl)ethylamino]benzamide.
Inventors
- 👤 Bola Vithal Shetty
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 06:38
CPC Classifications
C; C07; C07D; C07D209/00; C07D209/02; C07D209/44; C07D209/48; C07D211/00; C07D211/04; C07D211/06; C07D211/36; C07D211/40; C07D211/44; C07D211/52; C07D223/00; C07D223/14; C07D223/16; C07D239/00; C07D239/70; C07D239/72; C07D239/86; C07D239/88; C07D239/90; C07D239/91; C07D295/00; C07D295/04; C07D295/12; C07D295/125; C07D295/13; C07D295/16; C07D295/18; C07D295/182; C07D295/192; C07D471/00; C07D471/02; C07D471/10
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
154 words
A member of the group consisting of (a) a compound having the formula: ##STR8## wherein: R is H, alkyl of 1-4 carbons, hydroxy, alkoxy of 1-4 carbons, halogen, amino, --NHCOCH 3 or --NHCHO; A is (CH 2 ) n , where n is 1-5, or branched chain alkyl of 3-5 carbons; R 1 is alkyl of 1-4 carbons; phenyl; phenyl substituted with NH 2 , OH, OCH 3 or Cl; H when R is other than H or halogen; or phenalkyl of 7-10 carbons; R 2 is H or alkyl of 1-4 carbons; R 6 is H; alkyl of 1-4 carbons; alkanoyl of 1-4 carbons; benzoyl; phenyl; phenalkyl; or phenyl or phenalkyl substituted in the ring with NH 2 , OH, OCH 3 or Cl; R 7 is piperidyl, pyrrolidyl, --NH 2 , --NH-alkyl of 1-4 carbons, or --N═ (disubstituted with alkyl of 1-4 carbons); and (b) a pharmacologically acceptable acid addition salt thereof.
Claim 2
Dependent Claim
154 words
A member of the group consisting of (a) a compound having the formula: ##STR8## wherein: R is H, alkyl of 1-4 carbons, hydroxy, alkoxy of 1-4 carbons, halogen, amino, --NHCOCH 3 or --NHCHO; A is (CH 2 ) n , where n is 1-5, or branched chain alkyl of 3-5 carbons; R 1 is alkyl of 1-4 carbons; phenyl; phenyl substituted with NH 2 , OH, OCH 3 or Cl; H when R is other than H or halogen; or phenalkyl of 7-10 carbons; R 2 is H or alkyl of 1-4 carbons; R 6 is H; alkyl of 1-4 carbons; alkanoyl of 1-4 carbons; benzoyl; phenyl; phenalkyl; or phenyl or phenalkyl substituted in the ring with NH 2 , OH, OCH 3 or Cl; R 7 is piperidyl, pyrrolidyl, --NH 2 , --NH-alkyl of 1-4 carbons, or --N═ (disubstituted with alkyl of 1-4 carbons); and (b) a pharmacologically acceptable acid addition salt thereof.
Claim 3
Dependent Claim
20 words
The compound of claim 1 wherein R 1 is phenyl and each of R 2 and R 6 is hydrogen.
Claim 4
Dependent Claim
23 words
The compound of claim 2 wherein A is --CH(CH 3 )CH 2 --, R 7 is --NH 2 , and R is H.
Claim 5
Dependent Claim
23 words
The compound of claim 2 wherein A is (CH 2 ) 2 , R is 5-amino, and R 7 is --NH 2 .
Claim 6
Dependent Claim
23 words
The compound of claim 2 wherein A is (CH 2 ) 2 , R is 5-methoxy, and R 7 is --NH 2 .
Claim 7
Dependent Claim
23 words
The compound of claim 2 wherein A is (CH 2 ) 2 , R is 5-ethoxy, and R 7 is --NH 2 .
References Cited (Backward Citations)
US3497514A
Cited
US3635976A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-11-28 | 1981-05-30 | 1981-11-29 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-11-28 | 1985-05-30 | 1985-11-29 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-11-28 | 1989-05-30 | 1989-11-29 | $7700.00 | Window Closed / Lapsed |