US4058596A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Stabilized toothpastes containing an enzyme
Assignee: Colgate Palmolive Co
•
Filing: 1973-11-23
•
Granted: 1977-11-15
•
Expires: 1993-11-23
Abstract
Abstract Toothpastes having cosmetic and enzymatic stability containing a neutral protease of B.subtilis and a partially hydrolyzed protein.
Inventors
- 👤 Julius Harvey Nachtigal
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 02:36
CPC Classifications
A; A61; A61Q; A61Q11/00; A61K; A61K8/00; A61K8/18; A61K8/19; A61K8/30; A61K8/64; A61K8/65; A61K8/66; C; C12; C12N; C12N9/00; C12N9/96; A61K2800/00; A61K2800/40; A61K2800/52
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
122 words
A toothpaste formulation consisting essentially of about 0.2 to 10 percent by weight of a gelling agent and about 20 to 75 percent by weight of liquid vehicle proportioned to form a creamy mass, about 0.05 to 5 percent by weight of a water-soluble organic detergent, about 20 to 75 percent by weight of a dentally acceptable substantially water-insoluble polishing agent, at least about 0.05 percent by weight of the neutral protease of Bacillus subtilis and a stabilizer for retention of protease activity consisting essentially of about 0.1 to 0.5 percent by weight of a protein having an average molecular weight ranging from about 10,000 up to about 300,000 selected from the group consisting of partially hydrolyzed edible proteins and edible proteins.
Claim 2
Dependent Claim
122 words
A toothpaste formulation consisting essentially of about 0.2 to 10 percent by weight of a gelling agent and about 20 to 75 percent by weight of liquid vehicle proportioned to form a creamy mass, about 0.05 to 5 percent by weight of a water-soluble organic detergent, about 20 to 75 percent by weight of a dentally acceptable substantially water-insoluble polishing agent, at least about 0.05 percent by weight of the neutral protease of Bacillus subtilis and a stabilizer for retention of protease activity consisting essentially of about 0.1 to 0.5 percent by weight of a protein having an average molecular weight ranging from about 10,000 up to about 300,000 selected from the group consisting of partially hydrolyzed edible proteins and edible proteins.
Claim 3
Dependent Claim
35 words
The toothpaste of claim 1 in which the neutral protease is present in an amount of about 0.25 percent by weight and the protein is present in an amount of about 0.5 percent by weight.
Claim 4
Dependent Claim
24 words
The toothpaste of claim 1 in which the neutral protease has an activity of at least about 0.02 Anson units per gram of formulation.
Claim 5
Dependent Claim
26 words
The toothpaste of claim 1 in which the protein is selected from the group consisting of partially hydrolyzed gelatin, partially hydrolyzed casein, and partially hydrolyzed collagen.
Claim 6
Dependent Claim
22 words
The toothpaste of claim 3 in which the neutral protease has an activity of about 0.04 Anson units per gram of formulation.
Claim 7
Dependent Claim
17 words
The toothpaste of claim 1 in which said water-soluble organic detergent is N-2 ethyl laurate potassium sulfoacetamide.
Claim 8
Dependent Claim
25 words
The toothpaste of claim 1 wherein said polishing agent is selected from the group consisting of dicalcium phosphate dihydrate, dicalcium phosphate anhydrous, and calcium carbonate.
References Cited (Backward Citations)
US3325364A
Cited
US3696191A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-11-14 | 1981-05-16 | 1981-11-15 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-11-14 | 1985-05-16 | 1985-11-15 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-11-14 | 1989-05-16 | 1989-11-15 | $7700.00 | Window Closed / Lapsed |