Aromatic keto acids and derivatives having analgetic, antiinflammatory, and hypocholesterolemizing action

Abstract

Abstract This invention relates to new chemical compounds useful as drugs, as well as to pharmaceutical compositions containing the same. The new products are aromatic keto acid compounds with antiinflammatory as well as analgetic and hypocholesteremic activity and having the general formula ##STR1## wherein R 1 is hydrogen, halogen, phenyl, halophenyl, phenoxy, or substituted phenoxy. R 2 is hydrogen or alkoxy. R 1 and R 2 may form a ring, for instance: phenyl or cyclohexyl. R 3 is always other than hydrogen, being either methyl (CH 3 ) or methylene. When R 3 is CH 3 , a double bond is present between the A and B carbons. When R 3 is a methylene connected by a double bond to the B carbon, there can be only a single bond between the A and B carbons. The remaining valences of the A carbon atom are satisfied by hydrogen atoms. R 4 may be OH, alkoxy, ##STR2## The drugs containing these active principles are useful in the prevention and treatment of inflammatory syndromes, pain, and conditions involving excess cholresterol.

Inventors

• 👤 Henri Cousse
• 👤 Gilbert Mouzin
• 👤 Jean-Pierre Rieu

Bibliographic Details