US4058512A
Expired / Lapsed
US
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Synthetic peptides having growth promoting activity
Assignee: Phadia AB
•
Filing: 1975-04-28
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Granted: 1977-11-15
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Expires: 1995-04-28
Abstract
Abstract Novel synthetic peptides of the general formula ##STR1## and the corresponding reduced, linear form. The cyclic form of the peptide is produced by oxidation of the corresponding linear compound thereby providing the divalent dithio group --S--S-- joining the beta carbon of each of the cysteine moieties. In the above formula X is serine (SER) or lysine (Lys), and Y is OH or Thr-Glu-Gly-Phe. The obtained synthetic peptides, in either form, are useful in promoting growth of cells of mammalian tissues.
Inventors
- 👤 Hans Sievertsson
- 👤 Ronny Hugo Loritz Lundin
- 👤 Gertrud Elisabeth Westin Sjodahl
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 01:23
CPC Classifications
C; C07; C07K; C07K7/00; C07K7/04; C07K7/06; C07K14/00; C07K14/435; C07K14/575; C07K14/65; C07K7/08; A; A61; A61K; A61K38/00; Y; Y10; Y10S; Y10S435/00; Y10S435/811; Y10S930/00; Y10S930/01; Y10S930/12; Y10S930/26
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
46 words
Synthetic peptides of the general formula ##STR8## and the corresponding reduced, linear form where the link between the two Cys moieties in the oxidized form represents the dithio group, --S--S--; X = Ser or Lys; and Y = OH or Thr - Glu - Gly -Phe.
Claim 2
Dependent Claim
46 words
Synthetic peptides of the general formula ##STR8## and the corresponding reduced, linear form where the link between the two Cys moieties in the oxidized form represents the dithio group, --S--S--; X = Ser or Lys; and Y = OH or Thr - Glu - Gly -Phe.
Claim 3
Dependent Claim
4 words
The linear tridecapeptide aspartyl-glutaminyl-glutamyl-seryl-cysteinyl-lysyl-glycly-arginyl-cysteinyl-threonyl-glutamyl-glycyl-phenylalanine.
Claim 4
Dependent Claim
4 words
The linear tridecapeptide aspartyl-glutaminyl-glutamyl-seryl-cysteinyl-lysyl-glycly-arginyl-cysteinyl-threonyl-glutamyl-glycyl-phenylalanine.
Claim 5
Dependent Claim
4 words
The cyclic tridecapeptide: ##STR9##
Claim 6
Dependent Claim
4 words
The cyclic tridecapeptide: ##STR9##
Claim 7
Dependent Claim
27 words
The linear tridecapeptide: Asp - Gln - Glu - Lys - Cys - Lys -Gly - Arg - Cys - Thr - Glu - Gly - Phe.
Claim 8
Dependent Claim
27 words
The linear tridecapeptide: Asp - Gln - Glu - Lys - Cys - Lys -Gly - Arg - Cys - Thr - Glu - Gly - Phe.
Claim 9
Dependent Claim
4 words
The cyclic tridecapeptide: ##STR10##
Claim 10
Dependent Claim
4 words
The cyclic tridecapeptide: ##STR10##
Claim 11
Dependent Claim
22 words
The linear nonapeptide: Asp - Gln - Glu - Lys - Cys - Lys - Gly - Arg - Cys - OH.
Claim 12
Dependent Claim
22 words
The linear nonapeptide: Asp - Gln - Glu - Lys - Cys - Lys - Gly - Arg - Cys - OH.
Claim 13
Dependent Claim
4 words
the cyclic nonapeptide: ##STR11##
Claim 14
Dependent Claim
4 words
the cyclic nonapeptide: ##STR11##
References Cited (Backward Citations)
US3849388A
Cited
US3798203A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-11-14 | 1981-05-16 | 1981-11-15 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-11-14 | 1985-05-16 | 1985-11-15 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-11-14 | 1989-05-16 | 1989-11-15 | $7700.00 | Window Closed / Lapsed |